Ameliorative effects of arctiin from Arctium lappa on experimental glomerulonephritis in rats

The inhibition of activated hepatic stellate cells proliferation by arctigenin through G0/G1 phase cell cycle arrest: Persistent p27Kip1 induction by interfering with PI3K/Akt/FOXO3a signaling pathway

“…The inflammatory response in the injured liver has been considered to activate HSCs proliferation (King and Goodell, 2011;Schwabe et al, 2003). As a potent anti-inflammatory agent, ATG could exert its effects on lipopolysaccharide (LPS)-stimulated murine macrophages in vitro, colitis in mice and experimental glomerulonephritis in rats (Cho et al, 2002;Hyam et al, 2013;Wu et al, 2009;Zhao et al, 2009). In the present study, the effects of ATG on the proliferation of activated HSCs and underlying mechanisms were explored.…”

Essential oil from rhizomes ofLigusticum chuanxionginduces apoptosis in hypertrophic scar fibroblasts

“…It has been generally recognized that traditional Chinese herbal medicines play a unique therapeutic role in the treatment of many diseases (Zhang et al, 2008a;Du et al, 2009;Wu et al, 2009;Xing et al, 2009). In particular, the essential oils from many plant species have become popular in recent years, and the investigations on their bioactivities and mechanisms of action have been carried out for human health (Zhang et al, 2007(Zhang et al, , 2008bSamarth et al, 2008).…”

Effect of Poria cocos on Puromycin Aminonucleoside‐Induced Nephrotic Syndrome in Rats

“…Furthermore, the expression and apical targeting of ENaCs have been shown to be increased in the collecting ducts in PAN-induced nephrotic syndrome and to be aldosterone dependent [43, 44]. Aldosterone plasma levels were not measured in the current study; however, it is presumed that aldosterone secretion occurred based on the increased MR observed in rats with PAN-induced nephrotic syndrome.…”