Ameliorative Effects of Caffeic Acid on Lead Accumulation and Oxidative Stress in Lead-Exposed Mice

Lotfi-Ghahramanloo, Maryam; Baghshani, Hasan

doi:10.17795/zjrms-6674

Cited by 5 publications

(4 citation statements)

References 32 publications

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“…According to Alwaleedi [ 7 ], lead enters the human body through inhalation, skin, and the alimentary tract. Lead levels in the blood of about 40–60 ug/dL are considered very toxic [ 8 ]. A suspected lead poisoning case was reported in Nigeria in Unguwan communities, Niger state, Nigeria [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidative properties of Ocimum gratissimum alters Lead acetate induced oxidative damage in lymphoid tissues and hematological parameters of adult Wistar rats

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Antioxidative properties of Ocimum gratissimum alters Lead acetate induced oxidative damage in lymphoid tissues and hematological parameters of adult Wistar rats

et al. 2021

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“…The animals were feed by commercial chow diet (Behparvar Co., Karaj, Iran) containing 55% carbohydrate, 21% protein, 4% fat, 5% ber, 1.8% essential amino acids, and 4.8% minerals and vitamins. The mice were divided into four groups of eight: The treatment doses were selected according the previous conducted administration instruments for arsenite [26] and caffeic acid [17].…”

Section: The Arsenic-poisoned (Ap) Mice Model Preparation and Treatmentmentioning

confidence: 99%

“…The arsenic poisoning is currently threated by several chemical-and herbal-based antioxidants including ascorbic acid, taurine, betaine, and N-acetyl cysteine, have been reported to protect the human organs against the arsenic-or environmental-mediated oxidative stress and reduce the arsenic-provoked male reproductive diseases [13][14][15][16]. Utilizing the herbal-based antioxidant phytochemicals has been paid to attention as the widely available, safe, eco-friendly, and inexpensive therapeutic alternatives for the arsenic poisoning consequences [17,18].…”

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confidence: 99%

The Hepatorenal protective potential of caffeic acid consumption on the Arsenic-exposed Syrian mice

Chekneh,

Azadi,

Baghshani

et al. 2023

Preprint

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Background Arsenic can induce lethal hepatorenal insufficiency by inducing progressive cytotoxicity in the two main body’s hemostatic regulators, the kidney and liver. In the current study, the hepatorenal protective impact of Caffeic acid was investigated in Arsenic-exposed Syrian mice. Methods 24 male Syrian mice (30 \(\pm\)8 g) were provided and randomly divided into 4 groups of 6 receiving Nothing, Arsenic, Arsenic & caffeic, and caffeic acid. The mice passed the 21-day treatment program. The mice's blood was collected and analyzed by measuring the serum ALT/AST enzymes and Creatinine/Urea levels, respectively. Finally, the histopathological properties in both the kidney and liver organs of the mice were studied. Results Arsenic Administration significantly increased aspartate aminotransferase (AST), alanine aminotransferase (ALT), LDH, urea, and creatinine concentrations (p < 0.05). Simultaneous administration of caffeic acid with arsenic decreased the serum AST and creatinine (p < 0.05). Moreover, the renal glomerulus and liver regeneration in the mice receiving caffeic acid supplements exhibited the caffeic acid hepatorenal protective potential. Conclusion The histopathological changes caused by arsenic in the mice's liver and kidney tissue including degeneration, necrosis, hyperemia, and tissue hypotrophy were shifted to normal conditions following the Caffeic acid administration dose, which was verified by the mice blood biochemical analysis results.

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“…Various herbal elements have been recommended for steel poisoning (Pari and Prasath, 2008;Lotfi-Ghahramanloo and Baghshani, 2016). In epidemiological and experimental investigations, antioxidants and phenolic compounds were historically explored as chemoprotective retailers to regulate disease progression associated with oxidative pressure.…”

Section: Introduction Introduction Introduction Introductionmentioning

confidence: 99%

Therapeutic potential of caffeic acid and coumarin in modifying aluminum-induced hepatic injury in Wistar rats

CHOUARI,

KHAROUBI,

KESSAS

et al. 2024

Not Sci Biol

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Antioxidants and phenolic compounds have always been tested as chemoprotective agents to regulate disease progression related to oxidative stress. Through this study, we investigate the possible corrective effects of caffeic acid and coumarin against aluminum- (Al-) induced stress response and liver damage in rats. Male Wistar rats were divided into four groups (10 rats per group), cotreated with caffeic acid (30 mg kg-1) and coumarin (5 mg kg-1) and exposed to aluminum (60 mg kg-1) for 45 days. Al induced significant alterations in body and liver weight over time. It also led to a marked increase in plasma levels of transaminases (aspartate aminotransferase and alanine aminotransferase), alkaline phosphatase, and lactate dehydrogenase. Additionally, there was a substantial change in the lipid profile, characterized by elevated levels of triglycerides and total cholesterol in both serum and liver. Furthermore, the LDL-c level and the HDL-c/total cholesterol ratio in serum were also affected. In contrast, the levels of HDL-c in serum and phospholipids in liver tissues were reduced. The results of this study also showed increased levels of TBARS, protein carbonyls, nitrates/nitrites, and TNF-α. Conversely, the activity of antioxidant enzymes (catalase, GP-x, and SOD) was reduced. These altered parameters were restored after treating rats with caffeic acid and coumarin. Our study strongly suggests that caffeic acid and coumarin possess antioxidant properties and hepatoprotective capacity by attenuating aluminum toxicity-induced liver damage.

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Ameliorative Effects of Caffeic Acid on Lead Accumulation and Oxidative Stress in Lead-Exposed Mice

Abstract: Background: The currently approved treatment for lead toxicity is chelation therapy to reduce the burden of the toxic effects of lead, but the safety and efficacy of the various chelating agents may be questioned.

Cited by 5 publications

References 32 publications

Antioxidative properties of Ocimum gratissimum alters Lead acetate induced oxidative damage in lymphoid tissues and hematological parameters of adult Wistar rats

Antioxidative properties of Ocimum gratissimum alters Lead acetate induced oxidative damage in lymphoid tissues and hematological parameters of adult Wistar rats

The Hepatorenal protective potential of caffeic acid consumption on the Arsenic-exposed Syrian mice

Therapeutic potential of caffeic acid and coumarin in modifying aluminum-induced hepatic injury in Wistar rats

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