Ameliorative effects of chloroform fraction of Cocos nucifera L. husk fiber against Cisplatin-induced toxicity in rats

Adaramoye, Oluwatosin A.; Azeez, Adesola Fausat; Ola‐Davies, Olufunke Eunice

doi:10.4103/0974-8490.172658

Cited by 8 publications

(3 citation statements)

References 48 publications

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“…Data from this study showed that extracts from C. nucifera did not only scavenge free radicals but also inhibits peroxidation of lipids in both in vitro and in vivo models. Study also showed that pretreatment of cisplatin‐induced rats with chloroform extracts of C. nucifera husks inhibited lipid peroxidation and enhanced the antioxidant defense system of the experimental animals (Adaramoye, Azeez, & Ola‐Davies, ). Formation of lipid peroxidation byproducts such as malondiadehyde has been linked to reduction in concentration of reduced gluthatione in alloxan‐induced rats as evident in this study as well as other studies (Pari & Umamaheswari, ).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and alpha‐amylase inhibitory potentials of Cocos nucifera husk

Muritala

Akolade²,

Akande³

et al. 2018

Food Science & Nutrition

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Concoctions containing extract from Cocos nucifera husk fiber are used in Nigeria by traditional medicine practitioners for management of diabetes and its associated complications. Preliminary antidiabetic study was designed to validate the folkloric usage of the plant extract. Dried coconut husk fiber was pulverized and extracted with methanol, followed by partitioning of the methanolic extract in ethyl acetate. Phenolic content, radical scavenging activity and antioxidant capacity as well as inhibitory effects of C. nucifera methanolic (CN‐M) extract and its ethyl acetate (CN‐E) fraction on pancreatic α‐amylase and lipid peroxidation were determined. Total phenolic content and antioxidant capacity of CN‐E fraction were significantly higher than that of CN‐M extract, whereas there was no significant difference in their ability to scavenge free radicals. The CN‐E fraction also exhibited higher in vitro and in vivo inhibitory effects on α‐amylase activity and lipid peroxidation; reducing blood glucose level within 5 days following intraperitoneal administration of the C. nucifera extract to alloxan‐induced hyperglycemic rats. The phenolic‐rich extracts from coconut husk can be further explored as nutraceutical supplement in food formulation for diabetic patients.

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Section: Discussionmentioning

confidence: 99%

Antioxidant and alpha‐amylase inhibitory potentials of Cocos nucifera husk

Muritala

Akolade²,

Akande³

et al. 2018

Food Science & Nutrition

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“…Cisplatin was dissolved in saline. Acute renal toxicity was induced by intraperitoneal injection of 10 mg/kg cisplatin, a single dose, at day 5 [ 16 , 44 ].…”

Section: Methodsmentioning

confidence: 99%

Quinacrine Ameliorates Cisplatin-Induced Renal Toxicity via Modulation of Sirtuin-1 Pathway

El-Magd

Ebrahim

El-Sherbiny

et al. 2021

IJMS

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Renal toxicity is a serious side effect that hinders the use of cisplatin, a commonly used and effective chemotherapeutic agent. Meanwhile, quinacrine is an FDA approved drug that has been stated for its anti-inflammatory effect. Thus, we investigated the ameliorative effect of quinacrine against cisplatin-induced renal toxicity. Single intraperitoneal (i.p.) 10 mg/kg cisplatin administration induced renal injury in rats. Our results showed that 10 mg/kg/day quinacrine decreased the mortality rate of rats from 46.15% (cisplatin group) to 12.5%, and significantly decreased renal tissue fibrosis, relative kidney to body weight ratio, serum creatinine and urea levels compared with the cisplatin group. Indeed, quinacrine significantly decreased renal malondialdehyde concentration and increased renal total antioxidant capacity, compared with the cisplatin group. Furthermore, quinacrine caused significant upregulation of renal sirtuin-1 (SIRT-1) with significant downregulation of intercellular adhesion molecule-1 (ICAM-1) and tumor necrosis factor-α (TNF-α). Moreover, quinacrine significantly blocked cisplatin-induced apoptosis, which was made evident by downregulating renal apoptotic proteins (BAX and p53) and upregulating the renal anti-apoptotic protein BCL2, compared with the cisplatin group. In conclusion, this study demonstrates, for the first time, that quinacrine alleviates cisplatin-induced renal toxicity via upregulating SIRT-1, downregulating inflammatory markers (ICAM-1 and TNF-α), reducing oxidative stress, and inhibiting apoptosis.

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“…Research, Society and Development, v. 10, n. 10, e426101018994, 2021 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v10i10.18994 nucifera extract, intending to revert toxic effects induced by cisplatin in mice, Adaramoye and Ola-davies (2015) obtained positive results by administrating 200 mg/kg daily on mice diet, they also noticed a decrease in lipid peroxidation and intensification of antioxidant enzymes activity. And finally, the extract obtained from Orbignya phalerata presented a protective effect by modulating the inflammatory response, and the fruit extract from this species associated or not with aluminum particles increased interferons and interleukins concentration (Guerra, Silva, Aragão-frança, Oliveira, & Feitosa, 2011b).…”

Section: Anti-inflammatory and Protective Activitiesmentioning

confidence: 99%

Emerging source of bioactive compounds from Arecaceae family: a systematic review

Silva

Miranda

Amorim

et al. 2021

RSD

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The use of plants for medicinal purposes is performed empirically by traditional knowledge with the use of preparations that seek to extract their active principles, and are considered to be fundamental to human health. In this context, the aim of the present study was to of this study was to carry out a systematic review of the biological activities of the Arecaceae family distributed throughout Brazil. This research was carried out through a comprehensive search using the following databases, Scopus, Portal Periódicos Capes, PubMed, Google Scholar and Science Direct, using the following descriptors: “Arecaceae” and “Biological properties of the family Arecaeae”, checked at <www.theplantlist.org/> to check synonyms. It was possible to identify numerous biological activities in the arecaceae family, among the most recurring ones, the antioxidant, antimicrobial and anti-inflammatory activity. These activities are justified by the presence of fatty acids, phenolic compounds, alkaloids and terpenes. Studies routinely report lauric acid as a major in the plants of this family, which makes it a potential compound to cure or assist in the treatment of various diseases.

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Ameliorative effects of chloroform fraction of Cocos nucifera L. husk fiber against Cisplatin-induced toxicity in rats

Cited by 8 publications

References 48 publications

Antioxidant and alpha‐amylase inhibitory potentials of Cocos nucifera husk

Antioxidant and alpha‐amylase inhibitory potentials of Cocos nucifera husk

Quinacrine Ameliorates Cisplatin-Induced Renal Toxicity via Modulation of Sirtuin-1 Pathway

Emerging source of bioactive compounds from Arecaceae family: a systematic review

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