Ameliorative Effects of Dietary Selenium Against Cadmium Toxicity Is Related to Changes in Trace Elements in Chicken Kidneys

Abstract

The ameliorative effects of selenium (Se) against cadmium (Cd)-induced toxicity have been reported extensively. However, few studies have assessed the effects of multiple ions simultaneously on the variations of elements. In this study, the changes in Se, Cd, and 26 other element concentrations were investigated in chicken kidneys. One hundred and twenty-eight 31-week-old laying hens were fed a diet supplemented with either Se, Cd, or both Se and Cd for 90 days. The ion content was analyzed by inductively coupled plasma mass spectrometry (ICP-MS). We found that the Se, Cd, and combined Se and Cd treatments significantly affected the trace elements in the chicken kidneys. The Cd supplement caused ion profile disorders, including reduced concentrations of V, Cr, Mn, Mo, As, Ba, Hg, Ti, and Pb and increased Si, Cu, Li, Cd, and Sb. The Se supplement reduced the contents of Co, Mo, and Pb and increased the contents of Cr, Fe, and Se. Moreover, Se also increased the concentrations of Cr, Mn, Zn, and Se and decreased those of Li and Pb, which in contrast were induced by Cd. Complex interactions between elements were analyzed, and both positive and negative correlations among these elements are presented. The present study indicated that Se can help against the negative effects of Cd and may be related to the homeostasis of the trace elements in chicken kidneys.

Effects of Selenium and Cadmium on Breast Muscle Fatty-Acid Composition and Gene Expression of Liver Antioxidant Proteins in Broilers

“…Administration of selected trace elements, such as Se, as a remedy to ameliorate Cd toxicity, was lately evaluated in several studies [55,56,57]. Selenium exhibited protective effects against Cd toxicity by counteracting the immunosuppressive, as well as hepatic and renal oxidative, damage [58].…”

Selenium supplementation can protect from enhanced risk of keel bone damage in laying hens exposed to cadmium

“…Twenty-eight mineral elements [including those of Li, boron (B), sodium (Na), Mg, aluminum (Al), silicon (Si), potassium (K), Ca, titanium (Ti), vanadium (V), Cr, Mn, Fe, cobalt (Co), nickel (Ni), Cu, Zn, arsenic (As), Se, strontium (Sr), molybdenum (Mo), Cd, tin (Sn), antimony (Sb), barium (Ba), mercury (Hg), thallium (Tl), and Pb] from bone tissues, serum, basic diet and water were determined using inductively coupled plasma mass spectrometry, ICP-MS (Thermo iCAP Q, MA, USA). 26 Briey, 1.0 g or 0.5 mL of each sample was performed digestion in a solution of 5 mL 65% (w/w) HNO 3 and 2 mL 30% H 2 O 2 (w/v), then diluted to a nal volume of 10 mL with deionized water. Samples were heated in a microwaveaccelerated digestion system with the following heating program: (1) ramped up to 1800 W for 10 min, (2) 3 min at 100 C, (3) 10 min at 150 C, and (4) 45 min at 180 C. Aer cooling to room temperature, the digested samples were diluted with Milli-Q water to a nal volume of 50 mL and mixed well prior to ICP-MS analysis.…”

“…25 In our previous study, Cd supplementation of the chicken diet caused ion prole disorders in kidney, including drastic increases or decreases in thirteen mineral elements, and supplementation with Se increased the levels of chromium (Cr), manganese (Mn), Zn, and Se, and decreased lithium (Li) and lead (Pb), which in contrast were induced by Cd. 26 While it has been well established that levels of multiple elements are simultaneously altered, the interplay between these elements and indicators of bone damage under the effects of Se or Cd individually or combined, have yet to be studies.…”

Effects of selenium and zinc supplementation on cadmium toxicity in broilers

“…Following absorption from the lung and the gastrointestinal tract, Cd accumulation occurs primarily in liver and kidney where it is bound to metallothionein [5]. Cadmium toxicity is ameliorated by the administration of some trace elements including but not limited to selenium (Se) and zinc (Zn) [6][7][8]. Counteraction of immunosuppressive effects and oxidative damage of liver and kidney caused by exposure to Cd can be achieved by Se administration [9,10].…”