Ameliorative effects of fenugreek (Trigonella foenum-graecum) seed on type 2 diabetes

Abstract

The hyperglycaemia defines features of type 2 diabetes (T2DM), which is a real time problem and poses a significant economic burden on the globe and is spreading like an epidemic. Currently it affects 384 million people on the globe and this number is expected to reach 592 million in 2035 as reiterated by International Diabetes Federation (IDF). By improving the quality of diet and decreasing the intake of sugary foods T2DM can be treated. Fenugreek seeds powder in sachet form of 20 g/day used to treat type 2 diabetes mellitus as a natural supplement. Anthropometric parameters of height, weight, age and BMI of T2DM patient was also calculated. In this study patients from Rawalpindi and Islamabad region were selected for study purpose. Blood sugar levels such as fasting blood glucose (FBG), random blood glucose (RBG), and HbA1c of both the groups (treated and control) were taken at baseline, after one month and at the end of study. When fenugreek seeds were given to T2DM patients significant decrease in their glucose levels were seen after 30 and then 60 days of treatment.

The level of cardiac troponin T and its possible influence factors in maintenance hemodialysis patients

“…ROC curve analysis showed that the correlation between cTnT and CVD was higher than that between NT-proBNP and hsCRP. It also suggested that the increase of cTnT was closely related to the occurrence of CVD (Liu & Li, 2021;Rehman et al, 2021;Yerlikaya et al, 2021). Hill et al (2009) showed that the serum cTnT concentration in MHD patients without acute coronary syndrome was stable within 15 weeks, and the risk of death in MHD patients with increased cTnT was increased.…”

Secondary metabolites in sorghum and its characteristics

“…According to Brown & Gordon (2001) ß-glucanhas the same antitumor and antimicrobial stimulatory capabilities as dietary fiber. According to Khan et al (2021), ß-glucan is a soluble fiber and has been shown to reduce blood glucose and cholesterol levels, also supported by research by Rehman et al (2021) that besides that it can also lose weight.…”

Parthenolide regulates DNMT1-mediated methylation of VDR promoter to relieve podocyte damage in mice with diabetic nephropathy

“…In the in vitro diabetes model induced by high glucose (HG), 5-azacytidine treatment can significantly reduce the expression of DNMT1, and improve the reduction of podocyte slit diaphragm protein caused by hypermethylation (Zhang et al, 2017). At present, the treatment of type 2 diabetes with traditional Chinese medicine has become more and more common (Ahmad et al, 2020). Parthenolide (PN) was originally extracted from the shoots of plant Feverfew, and has strong anti-tumor, anti-inflammatory and antibacterial biological activities (Freund et al, 2020).…”