Ameliorative effects of gallic acid on GLUT-4 expression and insulin resistance in high fat diet-induced obesity animal model mice, Mus musculus

Baraskar, Kirti; Thakur, Pratibha; Shrivastava, Renu; Shrivastava, Vinoy K.

doi:10.1007/s40200-023-01194-5

Cited by 4 publications

(2 citation statements)

References 58 publications

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“…Galic acid which is widely found in Sumac is shown to have an inhibitory effect on carbohydrate digestive enzymes including α-amylase and α-glucosidase and thus could lower postprandial glycemic response and eventuality reduce the overall risk in diabetes patients ( 52 , 57 , 58 ). Furthermore, it is found that galic acid upregulates mRNA expression of GLUT-4 and IRS-1 in adipose tissue ( 59 ). Moreover, the quercetin content of Sumac could possibly be attributed to improved glucose metabolism in skeletal muscle cells and hepatocytes via stimulating AMPK and thus increased GLUT4 translocation ( 52 , 60 ).…”

Section: Discussionmentioning

confidence: 99%

The effect of Sumac on cardiometabolic parameters in adults: a systematic review and meta-analysis of randomized controlled trials

Jafarpour,

Jalali,

Akhlaghi

et al. 2024

Front. Nutr.

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BackgroundThe current evidence on the effect of Sumac consumption on cardiovascular parameters has produced controversial findings.MethodsWe systematically searched several databases, including PubMed-Medline, SCOPUS, and ISI Web of Science, to find eligible studies until January 2023. Meta-analysis to calculated the weighted mean difference (WMD) and 95 %CI, Sub-group meta-analysis and meta-regression analysis were conducted throughout the study.Results16 randomized controlled trials comprising a total number of 1,225 participants were included. The results of meta-analysis revealed that Sumac significantly affected low-density lipoprotein (WMD: −8.66 mg/dL; 95% CI: −14.2, −3.12), high-density lipoprotein (WMD: 3.15 mg/dL; 1.99,4.31), triglycerides (WMD: −11.96 mg/dL; −19.44, −4.48), fasting blood glucose (WMD: −4.15 mg/dL; −7.31, −0.98), insulin (WMD: −1.72; −3.18, −0.25), homeostasis model assessment of insulin resistance (HOMA-IR; WMD: −0.61; −1.22, −0.01), and anthropometric indices (p < 0.05). Moreover, the results significantly reduced total cholesterol when the intervention duration was ≥12 weeks (WMD: −8.58 mg/dL; −16.8, −0.37).ConclusionThese findings suggest that Sumac is potentially an effective complementary intervention to improve cardiometabolic parameters. Thus, patients could utilize Sumac as part of their diet to improve their overall cardiometabolic status.

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Section: Discussionmentioning

confidence: 99%

The effect of Sumac on cardiometabolic parameters in adults: a systematic review and meta-analysis of randomized controlled trials

Jafarpour,

Jalali,

Akhlaghi

et al. 2024

Front. Nutr.

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“…Leptin is accountable for bolstering insulin resistance through various means. Adiponectin increases insulin sensitivity in the liver by suppressing hepatic glycogenesis [ 20 ]. When compared to the control group, blood leptin levels in the T2DM group were considerably higher while adiponectin levels were lower.…”

Section: Discussionmentioning

confidence: 99%

Actinidia deliciosa Extract as a Promising Supplemental Agent for Hepatic and Renal Complication-Associated Type 2 Diabetes (In Vivo and In Silico-Based Studies)

El Azab,

Alakilli,

Saleh

et al. 2023

IJMS

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Type 2 diabetes (T2D) is a chronic metabolic condition associated with obesity, oxidative stress-mediated inflammation, apoptosis, and impaired insulin signaling. The utilization of phytochemical therapy generated from plants has emerged as a promising approach for the treatment of diabetes and its complications. Kiwifruit is recognized for its substantial content of antioxidative phenolics. Therefore, this work aimed to examine the effect of Actinidia deliciosa (kiwi fruit) on hepatorenal damage in a high-fat diet (HFD) and streptozotocin (STZ)-induced T2D in rats using in vivo and in silico analyses. An increase in hepatic and renal lipid peroxidation was observed in diabetic rats accompanied by a decrease in antioxidant status. Furthermore, it is important to highlight that there were observable inflammatory and apoptotic responses in the hepatic and renal organs of rats with diabetes, along with a dysregulation of the phosphorylation levels of mammalian target of rapamycin (mTOR), protein kinase B (Akt), and phosphoinositide 3-kinase (PI3K) signaling proteins. However, the administration of kiwi extract to diabetic rats alleviated hepatorenal dysfunction, inflammatory processes, oxidative injury, and apoptotic events with activation of the insulin signaling pathway. Furthermore, molecular docking and dynamic simulation studies revealed quercetin, chlorogenic acid, and melezitose as components of kiwi extract that docked well with potential as effective natural products for activating the silent information regulator 1(SIRT-1) pathway. Furthermore, phenolic acids in kiwi extract, especially syringic acid, P-coumaric acid, caffeic acid, and ferulic acid, have the ability to inhibit the phosphatase and tensin homolog (PTEN) active site. In conclusion, it can be argued that kiwi extract may present a potentially beneficial adjunctive therapy approach for the treatment of diabetic hepatorenal complications.

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Functional effects and mechanisms of Phyllanthus emblica fruit and gallic acid on metabolic diseases: Experimental evidence and clinical perspectives

Gou,

Ding,

et al. 2024

Food Bioscience

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Ameliorative effects of gallic acid on GLUT-4 expression and insulin resistance in high fat diet-induced obesity animal model mice, Mus musculus

Cited by 4 publications

References 58 publications

The effect of Sumac on cardiometabolic parameters in adults: a systematic review and meta-analysis of randomized controlled trials

The effect of Sumac on cardiometabolic parameters in adults: a systematic review and meta-analysis of randomized controlled trials

Actinidia deliciosa Extract as a Promising Supplemental Agent for Hepatic and Renal Complication-Associated Type 2 Diabetes (In Vivo and In Silico-Based Studies)

Functional effects and mechanisms of Phyllanthus emblica fruit and gallic acid on metabolic diseases: Experimental evidence and clinical perspectives

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