Ameliorative effects of gallic acid on cardio-renal complexity induced by isoproterenol

Abstract

Myocardial infarction (MI) arises out many risk factors, which work in concert and give rise to a lot of unfavorable outcome especially on the kidney. In the present study, we investigate the effect of gallic acid (GA), a natural antioxidant on cardio-renal complexity induced by isoproterenol (ISO). The myocardial infarcted rats showed deterioration in the heart function measured by lactate dehydrogenase (LDH) and creatin kinase (CK) and kidney function measured by urea, uric acid and creatinine. There were relative overweight in both the organs. Abnormal oxidation in lipids of their membrane indicated by the increased malomdialdhyde (MDA) content and nitrite level indicating the increase in their nitric oxide (NO). However, the result indicated a decrease in glutathione (GSH) content and superoxide dismutase (SOD) and peroxidase (POX) activities. These results were assured by other measurements as brain naturetic peptide (BNP) and myoglobin (Mgb) which indicated a damage happened in the myocytes, C-reactive protein (CRP) indicated the inflammatory response and homocystain, angiotensin and aldosterone levels which indicating the kidney hormones secretion. In conclusion, GA ascertained its efficacy in ameliorating the heart function biomarkers, kidney function testes and hormones and oxidation state.