Ameliorative effects of hempseed (Cannabis sativa) against hypercholesterolemia associated cardiovascular changes

Kaushal, Naveen; Dhadwal, Shallu; Kaur, Parminder

doi:10.1016/j.numecd.2019.09.006

Cited by 24 publications

(23 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High-fat diets (HFD) to induce experimental HC and diets containing HEMP were prepared as described earlier [ 14 ]. Briefly, animals were divided into five groups viz Control, HFD, HEMP, HFD+HEMP, and HFD/HEMP.…”

Section: Methodsmentioning

confidence: 99%

“…The hempseed powder was defatted using soxhlet extraction, and lipid and protein fractions were isolated as described previously [ 14 ]. Based on the previous studies suggesting the benefits of crude extracts over purified components and published results from our lab, only lipid fraction of hempseeds i.e.…”

Section: Methodsmentioning

confidence: 99%

“…Based on the previous studies suggesting the benefits of crude extracts over purified components and published results from our lab, only lipid fraction of hempseeds i.e. HEMP was used in the current study [ 14 ].…”

Section: Methodsmentioning

confidence: 99%

“…The protein expressions of Cox-2, hPGDS, mPGES, IL-4, TNF-α, and sEH were studied by Enzyme-Linked Immunosorbent Assay (ELISA) as described earlier using β-actin protein as an internal control [ 14 ].…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Hempseed (Cannabis sativa) lipid fractions alleviate high-fat diet-induced fatty liver disease through regulation of inflammation and oxidative stress

Kaushal

Gupta

Kulshreshtha

2020

Heliyon

Self Cite

View full text Add to dashboard Cite

Diet and lifestyle-induced dysregulated lipid metabolism have been implicated in fatty liver disease. Chronic redox modulation and hepatic inflammation are key pathological mediators and hallmarks of fatty liver disease associated liver steatosis and steatohepatitis. In this context, owing to the beneficial phytochemical properties such as optimal omega-6: omega-3 PUFA ratio of hempseed, we aimed to explore its potential anti-inflammatory and antioxidant properties against high-fat diet (HFD)-induced experimental model of fatty liver disease. The hempseed lipid fractions (HEMP) were prepared and their ameliorating effects on HFD induced morphological changes, lipid profiles, liver function markers (LFT), markers of oxidative stress and inflammation were studied. Results indicated that HEMP administration to hypercholesterolemic rats resolved the morphological, histopathological, and biochemical indicators of fatty liver diseases. Further, the mechanistic evidence revealed that these hepatoprotective effects of HEMP are mediated through inhibition of oxidative stress and inflammatory mediators such as Cox-2, hPGDS, mPGES, IL-4, TNF-α and sEH. In conclusion, current study suggests the plausible antioxidant and anti-inflammatory role of HEMP in alleviating pathophysiological conditions including fatty liver disease, where oxidative stress and inflammation are key mediators.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Hempseed (Cannabis sativa) lipid fractions alleviate high-fat diet-induced fatty liver disease through regulation of inflammation and oxidative stress

Kaushal

Gupta

Kulshreshtha

2020

Heliyon

Self Cite

View full text Add to dashboard Cite

show abstract

“…Elevated plasma levels of PUFAs indirectly decreased the risk of platelet aggregation and myocardial infarction and provided better defense against hypercholesterolemia [ 63 ]. Other issues caused by hypercholesteremia that were improved by supplementing hemp seed, including decreased cholesterol, low-density lipoprotein, and triglyceride levels, increased high-density lipoprotein levels, lower plaque, and fat deposition, and lower arterial wall damage [ 64 ].…”

Section: Potential Health Benefitsmentioning

confidence: 99%

Industrial Hemp (Cannabis sativa subsp. sativa) as an Emerging Source for Value-Added Functional Food Ingredients and Nutraceuticals

et al. 2020

View full text Add to dashboard Cite

Industrial hemp (Cannabis sativa L., Cannabaceae) is an ancient cultivated plant originating from Central Asia and historically has been a multi-use crop valued for its fiber, food, and medicinal uses. Various oriental and Asian cultures kept records of its production and numerous uses. Due to the similarities between industrial hemp (fiber and grain) and the narcotic/medical type of Cannabis, the production of industrial hemp was prohibited in most countries, wiping out centuries of learning and genetic resources. In the past two decades, most countries have legalized industrial hemp production, prompting a significant amount of research on the health benefits of hemp and hemp products. Current research is yet to verify the various health claims of the numerous commercially available hemp products. Hence, this review aims to compile recent advances in the science of industrial hemp, with respect to its use as value-added functional food ingredients/nutraceuticals and health benefits, while also highlighting gaps in our current knowledge and avenues of future research on this high-value multi-use plant for the global food chain.

show abstract

Hempseed

Oomah

2022

Molecular Mechanisms of Functional Food

View full text Add to dashboard Cite

Ameliorative effects of hempseed (Cannabis sativa) against hypercholesterolemia associated cardiovascular changes

Cited by 24 publications

References 27 publications

Hempseed (Cannabis sativa) lipid fractions alleviate high-fat diet-induced fatty liver disease through regulation of inflammation and oxidative stress

Hempseed (Cannabis sativa) lipid fractions alleviate high-fat diet-induced fatty liver disease through regulation of inflammation and oxidative stress

Industrial Hemp (Cannabis sativa subsp. sativa) as an Emerging Source for Value-Added Functional Food Ingredients and Nutraceuticals

Hempseed

Contact Info

Product

Resources

About