Ameliorative effects of melatonin against nano and ionic cobalt induced genotoxicity in two <i>in vivo</i> Drosophila assays

Ertuğrul, Havva; Yalçın, Burçin; Güneş, Merve; Kaya, Bülent

doi:10.1080/01480545.2019.1585444

Cited by 17 publications

(4 citation statements)

References 67 publications

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“…Therefore, we also suggest that, in the post-treatment, the anticarcinogenic effect of CEAC is due to the increased activity of proteins involved in repair pathways related to the tumor suppressor gene Warts, which promoted the control of cell proliferation and reduction of the formation of epithelial tumors. Importantly, we use the ETT test that assesses the toxicity, mutagenicity and carcinogenicity of different compounds [98,[102][103][104][105], based on phenotypic effects. However, it has been shown that aqueous and ethanolic extracts of A. chica inhibit inflammatory and angiogenic processes [89,106,107] and that its ethanolic extract also reduces the lipid oxidative stress marker malondialdehyde [67,108].…”

Section: Discussionmentioning

confidence: 99%

Arrabidaea chica chloroform extract modulates estrogen and androgen receptors on luminal breast cancer cells

Brandão

Lima

Martins

et al. 2022

BMC Complement Med Ther

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Background Breast Cancer (BC) is the most common cancer in women worldwide and, although 70% of patients are responsive to selective Estrogen Receptor (ER) modulators such as Tamoxifen (Tam), patients’ survival is comprised by resistance to endocrine therapy. Brazilian flora, especially the Amazon biome, is one of the richest global sources of native species with potentially bioactive compounds. Arrabidaea chica is a plant native to the Amazon that has been used in the treatment of different diseases. However, its action on BC remains unclear. Methods Herein the biological effects of the chloroform extract of A. chica (CEAC) were evaluated on BC cells and in in vivo model. After confirmation of CEAC antioxidant capacity, cells were treated with CEAC and Tam, alone and with CEAC+Tam. The cell viability was evaluated by MTT and hormone receptor transcripts levels were assessed (ESR1, ESR2 and AR). Finally, anticarcinogenicity of CEAC was recorded in Drosophila melanogaster through Epithelial Tumor Test (ETT). Results The study confirmed the antioxidant activity of CEAC. CEAC was selective for MCF-7, downregulating ESR2 and AR transcripts and upregulating ESR2 expression. The modulatory effects of CEAC on ERs did not differ between cells treated with Tam and with CEAC+Tam. Interestingly, previous treatment with CEAC, followed by treatment with Tam promoted a significant decrease in cell viability. The extract also presented anticarcinogenic effect in in vivo assay. Conclusion The bioassays on breast tumor cells demonstrated the antiproliferative activity of the extract, which modulated the expression of hormone receptors and sensitized luminal tumor cells to Tam. These results suggest that CEAC could be a complementary treatment for BC.

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Section: Discussionmentioning

confidence: 99%

Arrabidaea chica chloroform extract modulates estrogen and androgen receptors on luminal breast cancer cells

Brandão

Lima

Martins

et al. 2022

BMC Complement Med Ther

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“…Cu2O NP is a new type of inorganic nanomaterials. It can selectively inhibit the growth and proliferation of tumor cell lines by inhibiting the Wnt signaling pathway, inducing apoptosis of tumor cell lines, and also blocking the cycle of tumor cell lines (17,18). In addition, it has a broad clinical application prospect in the field of anti-tumor.…”

Section: Comparison Of the Shear Wave Velocity Of The Three Groups Of...mentioning

confidence: 99%

Analysis of Mechanism of Action of Cuprous Oxide Nanoparticles in Treatment of Cervical Cancer under Real-time Ultrasound Elastography

Liang¹,

Liu²,

Huang³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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It aimed to explore the adoption value of cuprous oxide nanoparticles (Cu2O NPs) in the clinical treatment of cervical cancer under the evaluation of real-time ultrasound elastography. In this experiment, the solution of Cu2O NPs was synthesized and used in 90 selected mouse models of cervical cancer. It was found that Cu2O NPs can significantly control the reproduction of various types of cervical cancer cells, effectively stopping the cycle of cervical cancer cell lines in the G1/G0 phase. In addition, the tumor weight of 0.25g in the Cu2O NPs group was notably lighter than that of 1.1g in the control group. The weight change of the mouse was 21g compared with 15g of the cis-dichlorodiamine platinum (CDDP) group, and it was proved that Cu2O NPs were less cytotoxic to the body and have few side effects. Moreover, real-time ultrasound elastography showed that there were 26 cases with a tumor elasticity score no less than 2 in the Cu2O NPs group, accounting for 87%, which was better than that of the CDDP group (17 cases, 57%), and the difference was substantial (P<0.05). The shear wave velocity of Cu2O NPs (1.46±0.48 m/s) was also lower than that (1.73±0.62 m/s) of the CDDP group, which suggested that the tumor body hardness of mice in the Cu2O NPs group was lower, and the difference was considerable (P<0.05). In short, Cu2O NPs had good functions such as inhibiting the proliferation and spread of tumor cells and blocking the cell cycle. Moreover, the toxic and side effects of the drug were slight, and it was an ideal new type of treatment for cervical cancer.

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“…Although both tests are accurate, sensitive, and specific, the wing-spot test allows the visual scoring of wings over time, whereas in the eye-spot test, the analysis should be performed quickly since no preserving actions are available on the eyes [ 17 ]. In fact, the SMART assays have been applied in the analysis of the genotoxicity and the antimutagenicity of several chemicals and agents such as pesticides [ 18 - 20 ], nanomaterials [ 21 , 22 ], food products [ 23 , 24 ], hormones [ 25 ], plant extracts [ 26 ], and drugs [ 27 - 29 ]. With this variety of studies, a bibliometric analysis is required to assess the impact of this methodology on the genotoxicity studies.…”

Section: Introductionmentioning

confidence: 99%

Publication trends of somatic mutation and recombination tests research: a bibliometric analysis (1984‒2020)

Tagorti

Kaya

2022

Genomics Inform

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Human exposure to pollutants has been on the rise. Thus, researchers have been focused on understanding the effect of these compounds on human health, especially on the genetic information by using various tests, among them the somatic mutation and recombination tests (SMARTs). It is a sensitive and accurate method applicable to genotoxicity analysis. Here, a comprehensive bibliometric analysis of SMART assays in genotoxicity studies was performed to assess publication trends of this field. Data were extracted from the Web of Science database and analyzed by the bibliometric tools HistCite, Biblioshiny (RStudio), VOSViewer, and CiteSpace. Results have shown an increase in the last 10 years in terms of publication. A total of 392 records were published in 96 sources mainly from Brazil, Spain, and Turkey. Research collaboration networks between countries and authors were performed. Based on document co-citation, five large research clusters were identified and analyzed. The youngest research frontier emphasized on nanoparticles. With this study, how research trends evolve over years was demonstrated. Thus, international collaboration could be enhanced, and a promising field could be developed.

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Ameliorative effects of melatonin against nano and ionic cobalt induced genotoxicity in two in vivo Drosophila assays

Cited by 17 publications

References 67 publications

Arrabidaea chica chloroform extract modulates estrogen and androgen receptors on luminal breast cancer cells

Arrabidaea chica chloroform extract modulates estrogen and androgen receptors on luminal breast cancer cells

Analysis of Mechanism of Action of Cuprous Oxide Nanoparticles in Treatment of Cervical Cancer under Real-time Ultrasound Elastography

Publication trends of somatic mutation and recombination tests research: a bibliometric analysis (1984‒2020)

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