Ameliorative Effects of Mentha Spicata Essential Oil on Lead and Manganese- Induced Brain Oxidative Damage in Rats

Brahmi, Mostapha; Houari, Adli Djallal Eddine; Hachem, Kadda; Arabi, Wafaa; Nariman, Taibi; Slimani, Miloud; Khaled, K.F.

doi:10.33289/ijrpc.10.2.2020.10(35)

Cited by 1 publication

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The defensive effects of Peppermint oil against the oxidative damage induced by Piroxicam might explain the strong positive reaction to PAS staining in the liver of group III. Such findings have been previously confirmed by Mostapha et al [38].…”

Section: Discussionsupporting

confidence: 80%

Histological changes induced by Piroxicam on the hepatic and renal tissues of mice with and without administration of Peppermint oil

Al-Hamdany

Al-Tai

Ismail

2022

Current Issues in Pharmacy and Medical Sciences

View full text Add to dashboard Cite

Piroxicam is a popular anti-inflammatory drug that displays palliative and antipyretic activity. Peppermint oil is a common flavoring used in foods and drinks. To investigate the defensive action of Peppermint oil against the hepatic and renal histological damage induced by Piroxicam in mice. Forty healthy adult Swiss albino mice of both sexes were categorized into 4 groups (10 mice in each group): Control group (I); Treatment group (II) – injected with Piroxicam 0.3 mg/kg/rat/day via intraperitoneal route for 28 days; Treatment group (III) – oral Peppermint oil 0.2 ml/kg/day by oral gavage 24 hours preceding each injection of Piroxicam; Treatment group (IV) oral Peppermint oil alone. Blood samples were withdrawn to estimate the hepatic and renal functions. Immediately after death, specimens of liver and kidney from the four groups were isolated and put in 10% concentration buffered formalin for 24 hours then prepared for light microscopic examination. There was a highly significant rise in the serum level of hepatic enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase and total serum bilirubin) in the group treated with Piroxicam, as compared to the control group. These returned to near normal level in the group treated with Piroxicam and Peppermint oil. Liver samples of the treated mice showed ballooning degeneration of hepatocytes, small apoptotic hepatocytes and inflammatory cellular infiltration, whereas kidney sections revealed cystic dilatation of Bowman’s space, shrinkage of glomerular tuft and apoptosis of epithelial cells lining the tubules. In contrast, the addition of peppermint oil efficiently ameliorated the hepatic and renal tissue changes. Piroxicam induces hepatorenal toxicity as exhibited by histological, histochemical and biochemical findings. Peppermint oil shows ameliorative properties against the hepatorenal toxic effects induced by Piroxicam.

show abstract

Section: Discussionsupporting

confidence: 80%