Ameliorative effects of physcion 8-O-β-glucopyranoside isolated fromPolygonum cuspidatumon learning and memory in dementia rats induced by Aβ1–40

Xu, Ning; Zhou, Xiao; Zou, Ting; Huang, Zhiling

doi:10.3109/13880209.2014.997251

Cited by 10 publications

(7 citation statements)

References 28 publications

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“…The subsequent effects of ACh depend on the role of AChE in the synaptic cleft; AChE can hydrolyze ACh into choline and acetic acid, which has a very high catalytic activity, thus ensuring that the concentration of ACh declines rapidly (21). Therefore, AChE and choline acetyltransferase activities in the brain can indirectly reflect ACh content, and can thus be used to infer the functional status of the central cholinergic system (22). Furthermore, the present study indicated that tetrahydropalmatine significantly decreased the ketamine-induced increase in AChE activity and reversed the ketamine-induced decrease in ACh levels, demonstrating that tetrahydropalmatine protected nerve cell apoptosis in ketamine-induced mice.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of tetrahydropalmatine against ketamine-induced learning and memory injury via antioxidative, anti-inflammatory and anti-apoptotic mechanisms in mice

Zhang

Sha²,

Wang

et al. 2018

Mol Med Report

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Tetrahydropalmatine exerts numerous pharmacological activities, including analgesic and narcotic effects; anti-arrhythmic, blood pressure lowering and cardioprotective effects; protective effects against cerebral ischemia-reperfusion injury; inhibition of platelet aggregation; prevention of ulcerative diseases and inhibition of gastric acid secretion; antitumor effects; and beneficial effects on the withdrawal symptoms associated with drug addiction. The present study aimed to investigate the protective effects of tetrahydropalmatine against ketamine-induced learning and memory impairment in mice. The Morris water maze test and open field test were used to analyzed learning and memory impairment in mice. ELISA kits and western blotting were used to analyze oxidative stress, inflammation factors, caspease-3 and caspase-9, iNOS, glial fibrillary acidic protein (GFAP), glial cell-derived neurotrophic factor (GDNF), cytochrome c and phospholipase C (PLC)-γ1 protein expression. The results demonstrated that tetrahydropalmatine treatment significantly decreased escape latency in the learning phase and increased the number of platform site crossings in ketamine-induced mice. In addition, tetrahydropalmatine significantly inhibited oxidative stress, inflammation and acetylcholinesterase activity, and decreased acetylcholine levels in ketamine-induced mice. Tetrahydropalmatine also suppressed iNOS protein expression, weakened caspase-3 and caspase-9 activation, inhibited nuclear factor-κB, glial fibrillary acidic protein, cytochrome c and phospholipase C-γ1 protein expression, and induced glial cell-derived neurotrophic factor protein expression in ketamine-induced mice. Taken together, these results indicated that tetrahydropalmatine may protect against ketamine-induced learning and memory impairment in mice via antioxidative, anti-inflammatory and anti-apoptotic mechanisms. The present study provided an experimental basis for the clinical application of tetrahydropalmatine to reduce the severe side effects associated with ketamine therapy in future studies.

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Section: Discussionmentioning

confidence: 99%

Protective effects of tetrahydropalmatine against ketamine-induced learning and memory injury via antioxidative, anti-inflammatory and anti-apoptotic mechanisms in mice

Zhang

Sha²,

Wang

et al. 2018

Mol Med Report

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“…Asian royal fern --- [39] Frangula rupestris ---Stem bark [21] Vismia rubescens ---Stem bark [33] Eurotium cristatum ------ [41] Reynoutria elliptica Asian knotweed --- [31] Microsporum sp ------ PG is a biologically active component of Rheum palmatum [44], Rheum officinale, Polygonum multiflorum, Polygonum reynoutria [45], Polygonum cuspidatum [46], Reynoutria sachalinensis [47], Fallopia sachalinensis [48] and Rumex japonicus Houtt (Figure 2) [49][50][51][52].…”

Section: Osmunda Japonicamentioning

confidence: 99%

“…The biologically and pharmacologically active anthraquinones, physcion and PG have been wellknown for their potential anti-cancer [19, 22-23, 28, 49, 51] and anti-inflammatory activities [34,53]. Moreover, physcion also shows anti-microbial [33] and hepatoprotective properties [54] while PG displays ameliorative effects against dementia [46] and have anti-sepsis properties [55]. This review spotlights on the mechanism by which both these compounds act to combat cancer progression.…”

Section: Biological Activities Of Physcion and Pgmentioning

confidence: 99%

Physcion and Physcion 8-O-β-D-glucopyranoside: Natural Anthraquinones with Potential Anticancer Activities

Shah

Adnan

Rasul

et al. 2021

CDT

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: Nature has provided prodigious reservoirs of pharmacologically active compounds for drug development since times. Physcion and physcion 8-O-β-D-glucopyranoside (PG) are bioactive natural anthraquinones which exert anti-inflammatory and anti-cancer properties with minimum or no adverse effects. Moreover, physcion also exhibits anti-microbial and hepatoprotective properties while PG is known to have anti-sepsis as well as ameliorative activities against dementia. This review aims to highlight the natural sources and anti-cancer activities of physcion and PG along with asso-ciated mechanisms of actions. On the basis of the literature, physcion and PG regulate multitudinous cell signaling path-ways through the modulation of various regulators of cell cycle, protein kinases, microRNAs, transcriptional factors, and apoptosis linked proteins resulting in the effective killing of cancerous cells in vitro as well as in vivo. Both compounds effectively suppress metastasis, furthermore, physcion acts as inhibitor of 6PGD and also play an important role in chemosensitization. This review article suggests that physcion and PG are potent anti-cancer drug candidates but further investigations on their mechanism of action and pre-clinical trials are mandatory in order to comprehend the full potential of these natural cancer killers in anti-cancer remedies.

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“…Physcion 8-O-β-glucopyranoside (PSG) isolated from knotweed can significantly enhance learning and memory in Aβ1-40-induced dementia rats, and the mechanisms may be related to increase levels of acetylcholine, serotonin, noradrenaline, and dopamine, decrease Aβ contents, and up-regulation of dendritic spine protein drebrin [99] (Shim et al, 2002) in hippocampus [100].…”

Section: Physcion 8-o-β-glucopyranosidementioning

confidence: 99%

BIOLOGICALLY ACTIVE COMPOUNDS OF KNOTWEED (Reynoutria spp.)

Patočka¹,

Navrátilová²,

Ovando³

2017

MMSL

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Knotweeds (Reynoutria Houtt.) are plants native to the Far East. Japanese knotweed was introduced from Japan to the unsuspecting West by the horticultural activities of Philippe von Siebold via his nursery at Leiden in the 1840s. By 1854, the plant had arrived at the Royal Botanic Gardens in Edinburgh. The plants were then sold by a large number of commercial nursery gardens around the country. Further vegetative spread followed naturally along watercourses. The knotweed is currently extremely persistant invasive plant. There is also an important source of many bioactive substances which could be used in biomedicine. The article discusses biomedically relevant constituents and its pharmacological and toxicological properties.

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Ameliorative effects of physcion 8-O-β-glucopyranoside isolated fromPolygonum cuspidatumon learning and memory in dementia rats induced by Aβ_1–40

Cited by 10 publications

References 28 publications

Protective effects of tetrahydropalmatine against ketamine-induced learning and memory injury via antioxidative, anti-inflammatory and anti-apoptotic mechanisms in mice

Protective effects of tetrahydropalmatine against ketamine-induced learning and memory injury via antioxidative, anti-inflammatory and anti-apoptotic mechanisms in mice

Physcion and Physcion 8-O-β-D-glucopyranoside: Natural Anthraquinones with Potential Anticancer Activities

BIOLOGICALLY ACTIVE COMPOUNDS OF KNOTWEED (Reynoutria spp.)

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