Ameliorative effects of quercetin against hepatic toxicity of oral sub-chronic co-exposure to aluminum oxide nanoparticles and lead-acetate in male rats

Abstract

The present study was designed to evaluate the probable ameliorative role of quercetin (QCN) against oxidative hepatotoxicity induced by aluminum oxide nanoparticles (Al2O3NPs) with a diameter < 30 nm and lead acetate (Pb) co-exposure in adult male Sprague–Dawley rats. Rats were weighed and allocated to seven groups (n = 10 each) and were treated orally via orogastric gavage for 60 successive days: rats of the 1st group were kept as control given distilled water (1 ml/kg), rats of the 2nd group received 2 ml/kg BW/day corn oil; rats of the 3rd group were administered 20 mg/kg BW QCN/day; rats of the 4th group received 100 mg/kg BW Al2O3NPs; rats of the 5th group received 50 mg/kg BW Pb; rats of the 6th group co-received Al2O3NPs and Pb at the same previous doses; and rats of the 7th group were co-administered Al2O3NPs, Pb, and QCN at the same previous doses. At the end of the experiment, serum levels of alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total, direct, indirect bilirubin, triglycerides, total cholesterol, HDL, VLDL, and LDL were estimated. The hepatic oxidative stress biomarkers as superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GPx), were also evaluated. Finally, the histopathological and histomorphometric evaluations and the residues of Al and Pb in hepatic tissues were assessed. Al2O3NPs and/or Pb exposure significantly elevated lipid peroxidation levels and considerably altered the hepatic biochemical parameters; nevertheless, QCN significantly reduced hepatic enzymes compared to toxicant exposed groups. Additionally, QCN significantly improved Al2O3NPs-afforded liver tissue damage, as established in microscopic findings on the liver in the group treated with Al2O3NPs + Pb. Conclusively, QCN could be a candidate natural agent to safeguard the liver versus the co-harmful impacts of Al2O3NPs and Pb toxicity.

Bee venom (Apis mellifera L.) rescues zinc oxide nanoparticles induced neurobehavioral and neurotoxic impact via controlling neurofilament and GAP-43 in rat brain

“…The change in body weight is one of the most widely used parameters in toxicological assessments to indicate the toxic effects of a substance on the health status of animals (Wang et al 2019a ). Thus, in most medical and environmental toxicology research on the effects of certain substances on the body, animal body mass and organ mass have been frequently measured (Abo-El-Sooud et al 2023 ; Fadil et al 2023 ). In the current study, ZNPs-exposed rats showed a significant reduction in daily weight gain compared to their respective control.…”

Entomotherapeutic Role of Periplaneta americana Extract in Alleviating Aluminum Oxide Nanoparticles-Induced Testicular Oxidative Impairment in Migratory Locusts (Locusta migratoria) as an Ecotoxicological Model

“…To hinder the toxicological effects, in particular the oxidative stress engendered by Al 2 O 3 NPs, many endeavors have been dedicated to discovering natural products with intrinsic antioxidant capacities. The major studies focused on antioxidant-derived plants that contain bioactive polyphenolic compounds such as quercetin to reduce oxidative damage in hepatic cells after treatment with Al 2 O 3 NPs [ 17 , 18 , 19 ]. So far, very little attention has been paid to antioxidant-derived insects to tackle the deleterious consequences of the metal NPs.…”

Danos oxidativos e teciduais induzidos pela exposição subcrônica ao acetato de chumbo em morcegos frugívoros que atuam no reflorestamento da Mata Atlântica

“…Quando ativadas, pela presença de Pb, por exemplo, células de defesa como macrófagos secretam NO e aumentam os níveis desse radical tóxico para o tecido(Abdel Moneim, 2016). Em conformidade com nosso estudo, ratos expostos oralmente a 50 mg/kg de acetato de Pb durante 60 dias também apresentaram dilatação de capilares sinusóides e maior incidência de infiltrados leucocitários no fígado (Abo-EL- Sooud et al, 2022). Codornas expostas oralmente a 50, 250, 500 e 1000 mg/kg de acetato de Pb durante 49 dias apresentaram diminuição na atividade enzimática da SOD, CAT e GST, e…”