Ameliorative Effects of Quercetin on Sodium Fluoride-Induced Oxidative Stress in Rat’s Kidney

Abstract

Objective: The in vivo nephroprotective effect of quercetin against sodium fluoride (NaF)-induced damage was studied. Methods: Renal injury was induced by daily administration of NaF (600 ppm) through drinking water for 1 week. The levels of reduced glutathione (GSH), lipid peroxidation as well as superoxide dismutase and catalase activity of kidney homogenates were determined. The serum markers of glomerular damage, including creatinine, serum urea, and blood urea nitrogen levels, were also assessed. Results: The study revealed that administration of fluoride resulted in a significant downregulation of antioxidant defenses coupled with an increased serum level of glomerular damage markers. The administration of quercetin prior to fluoride reversed the antioxidant-oxidant balance to control (fluoride-untreated) level. The level of protection obtained for the 20 mg/kg quercetin treatment was equivalent to the positive control, ascorbic acid (10 mg/kg). The therapeutic implication of antioxidants in fluoride-induced nephrotoxicity is discussed. Conclusions: This study showed that NaF intoxication caused renal damage by increasing oxidative stress, and quercetin and vitamin C administration gave protection against fluoride-induced oxidative stress to some degree.

Protective and curative effects of Boerhaavia diff usa L. against fl uoride induced renal oxidative stress and antioxidant enzymes in rats

“…The present results are in accordance with previous fl uorosis reports [3,13,19]. Decrease in the level of fl uoride after mitigation with leaf extract also resulted in signifi cant increase in content of reduced glutathione as compared with 40 days of fl uoride treatment.…”

“…It was observed that sodium fl uoride exposure in rats caused a signifi cant (p<0.001) decrement in total activity of superoxide dismutase, catalase, and glutathione peroxidase. This fi ndings are in accordance with [13,15,16,22]. Boerhaavia diff usa L. leaf extract administration signifi cantly (p<0.001) accelerated the renal activities of superoxide dismutase, catalase, and glutathione peroxidase in fl uoridated rats kidney tissue.…”

A Network Pharmacology Approach to Understanding the Mechanisms of Action of Traditional Medicine: Bushenhuoxue Formula for Treatment of Chronic Kidney Disease

“…Calycosin promotes angiogenesis via activation of MAPK with the involvement of ERK1/2 and ER [94]. The degree node of quercetin from CS was 4, which is from its antioxidant that protects renal function [95].…”

Extractability of Rutin in Herbal Tea Preparations of Moringa stenopetala Leaves

“…As shown in Table 1, the water extract showed antioxidant activity comparable with the methanol extract (p > 0.05). The validation of antioxidant potential of herbal medicines in our laboratories is based on several in-house in vitro cell-free and cell-based assays [33][34][35][36][37][38][39][40][41][42][43][44] as well as in vivo models [45][46][47][48][49][50][51][52][53][54]. Since the principal active constituent of the methanol and water extracts of M. stenopetala leaves is the well-characterised antioxidant and bioactive agent rutin, further biological bioassays on the extracts were not necessary.…”