Ameliorative effects of resveratrol on liver injury in streptozotocin‐induced diabetic rats

Abstract

The objective of this study was to investigate the ameliorative property and potential mechanism of resveratrol (RVT) in a dose of 10 mg/kg for 15 consecutive days against liver injury in streptozotocin-induced diabetic rats. Diabetic rats significantly (P < 0.05) exhibited liver injury manifested by increased aspartylaminotransferase, alanine aminotransferase, and bilirubin; disturbed liver weight to body weight; and confirmed by hematoxylin and eosin staining. Liver from diabetic rats exhibited significant increase in malondialdehyde level and significant decrease in reduced glutathione, glutathione-S-transferase, quinone reductase, catalase, and superoxide dismutase. Diabetic rats showed significant disturbance in serum lipid profile. Treatment with RVT significantly (P < 0.05) abrogated diabetes-induced perturbation in these parameters and liver histology. These data suggest that RVT treatment is associated with promising hepatoprotective effect against diabetes-induced liver damage via reduction of serum glucose level and oxidative damage and improving serum lipid profile.

Resveratrol and Loratadine Effects on Oxidative Stress Induced by Experimental Inflammation

“…The catalase activity in the liver is significantly increased by resveratrol, in comparison with all other groups. This result is in concordance with studies performed in diabetic rats with liver injury [13] and in senescence-accelerated mice [14] that proved that resveratrol increases the CAT and GSH concentration in liver.…”

The effects of caffeic acid phenethyl ester on streptozotocin-induced diabetic liver injury

“…This study investigates whether CAPE has protective effects on the STZ-induced liver damage. Hepatocellular damage developed in the liver after STZ administration in rats has been shown by several authors (10,30). Vardi et al have reported deterioration in the radial placement of hepatocytes starting from the central veins towards the periphery in the liver and hydropic change in hepatocytes located at the periphery of the lobules (30).…”

“…Oxidative stress is measured by indices of lipid peroxidation (LPO) such as malondialdehyde (MDA), antioxidant enzymes including superoxide dismutase (SOD) and glutathione-S-transferases (GSTs) (10). Oxidative stress has been documented in hyperglycemia of both type 1 and type 2 diabetes and thus should be regarded as central player in the development of diabetes complications (3).…”

Resveratrol: A miraculous natural compound for diseases treatment

“…It should be noted that effects of RSV in the liver are originated from increasing blood insulin level. In addition, RSV alleviated liver tissue abnormalities by hepatoprotective effects (Hamadi, Mansour, Hassan, Khalifi‐Touhami, & Badary, 2012). Overall, the anti‐diabetic effects of resveratrol well established in diabetic animals (Chang et al., 2011, 2014; Hamadi et al., 2012; Ku et al., 2012).…”

“…In these patients, body resists the effects of insulin hormone or shows an insulin secretion deficiency. It is recently established that factors such as inflammation and oxidative stress contribute to worsening of insulin resistance and to β‐cell failure in type 2 diabetics (Hamadi et al., 2012). Besides, insulin resistance in adipocytes, hepatocytes, and muscle cells is still complicating issue.…”