Ameliorative effects of rutin against cisplatin-induced reproductive toxicity in male rats

Jahan, Sarwat; Munawar, Asma; Razak, Suhail; Anam, Sara; Ain, Qurat Ul; Ullah, Hanif; Afsar, Tayyaba; Abulmeaty, Mahmoud M. A.; Almajwal, Ali

doi:10.1186/s12894-018-0421-9

Cited by 63 publications

(52 citation statements)

References 68 publications

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“…These histopathological changes were reversed with dose-dependent manner in mice treated with Ficus carica extract. The mentioned results coincide well with the findings of other authors who demonstrated that cisplatin had impaired spermatogenesis and resulted in gonadal dysfunction, altered Leydig cells and antioxidant enzyme status 12 . Also temporary or permanent azoospermia are other forms of side effects associated with cisplatin treatment.…”

Section: Discussionsupporting

confidence: 92%

“…Like other chemotherapeutic drugs CP possesses many side effects in clinical uses and experimental animal studies. The use of CP for clinical purposes is limited by its side effects 12 .…”

Section: Discussionmentioning

confidence: 99%

“…It works in part by binding to DNA and inhibiting its replication 9 . Like other chemotherapeutic drugs, cisplatin possesses many adverse side effects in patients under its treatment including: genotoxicity 10 , nephrotoxicity 8 , liver dysfunction 11 and reproductive impairment 12 .…”

Section: Introductionmentioning

confidence: 99%

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Protective Role of Ficus carica Extract Against Hepato-Testicular Side Effects and Genotoxicity Induced by Cisplatin

Fahmy¹,

Hassan²,

Ibrahim³

et al. 2020

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Preparation and chemical investigation of Ficus carica extract The leaves of Ficus carica were collected from Giza governorate, Egypt, in Sep. 2018, and identified by ABSTRACT Objective: The present work investigated the protective effect of Ficus carica (common fig) leaves methanol extract against genotoxicity and testicular damage of cisplatin (CP) and identified some of its active ingredients. Methods: Seven main groups were investigated as follows: I. control negative, II. Control plant (600 mg/kg fig, orally), III, IV. Control positive (treated i.p with 10 and 15 mg/kg CP), V-VII. groups treated with fig (200, 400 and 600 mg/ kg) + Cisplatin (15 mg/kg). Results: Ficus carica alleviated the destructive effects of CP in the testis, liver and bone marrow due to the presence of high amount of flavonoids and phenolic compounds. Also it has a normal effect in the tested parameters as compared with the control negative. Chromatographic investigation resulted in the identification of 6 compounds: Catechin, Luteolin-8-C-β-D glucopyranoside, Quercetin, Quercetin-3-O-β-d-glucopyranoside, Chlorogenic acid and Kaempferol-3-O-β-D-glucopyranoside. In bone marrow cisplatin induced significant percentage of chromosome abnormalities, micronuclei in polychromatic erythrocytes and toxicity to cells. On the contrary the two tested doses of cisplatin had a normal effect on spermatocyte chromosomes (germ cells). The dose 15 mg/kg induced an overexpression of the liver genes NF-kB and iNOS as indicated by real-time PCR. Different forms of histopathological alterations and instigation of the expression of TNF-α gene in the testis were detected after CP treatment. Conclusion: Ficus carica is a promising candidate rich in many bioactive constituents and can be used in combination with chemotherapeutic drugs to alleviate their destructive effects.

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Section: Discussionsupporting

confidence: 92%

“…Like other chemotherapeutic drugs CP possesses many side effects in clinical uses and experimental animal studies. The use of CP for clinical purposes is limited by its side effects 12 .…”

Section: Discussionmentioning

confidence: 99%

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Protective Role of Ficus carica Extract Against Hepato-Testicular Side Effects and Genotoxicity Induced by Cisplatin

Fahmy¹,

Hassan²,

Ibrahim³

et al. 2020

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“…In another cisplatininduced testicular toxicity study it was found that only cisplatin treatment resulted in a significant decrease in daily sperm production, head length and % DNA in head, reduction of epithelial cells height, tubular diameter, number of spermatogonia, spermatocytes and spermatids, the intratesticular testosterone concentrations, increase in the thiobarbituric acid reactive substances (TBARS) and oxidative stress in testicular tissues. Rutin treatment to cisplatin-treated rats resulted in reversing cisplatin's effects on DNA damage, sperm count, histological and biochemical parameters, thus suggesting the shielding effects of rutin against cisplatin-induced testicular toxicity (Jahan et al, 2018). The effects of rutin on diabetic-induced impairments in sexual behaviour, spermatogenesis and oxidative testicular damage have also been reported.…”

Section: Protective Ability Against Testicular Toxicitymentioning

confidence: 89%

A review on the chemistry and biological properties of Rutin, a promising nutraceutical agent

Prasad¹,

Prasad²

2019

Asian J Pharm Pharmacol

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Nature is an attractive source of new therapeutic agents and a variety of phytochemicals have proved to be very valuable in the prevention and treatment of various diseases. Many of the important drugs isolated from plants during the past 50 years have revolutionized modern medicinal practice (Dar et al., 2017). The use of herbal medicines and phytonutrients or nutraceuticals continues to expand rapidly across the world with many people now resorting to these products for the treatment of various health challenges in different national healthcare settings (WHO, 2004). It is estimated that up to 80% of the world's population living in the developing countries rely on herbal medicinal products as a primary source of healthcare and traditional medical practice as an integral part of the culture in their communities (Ekor, 2013). The medicinal compounds derived from various plants could be divided into three major biochemical classes: alkaloids (vinblastine, vincristine, pilocarpine, berberine, caffeine, piperine etc.), flavonoids (quercetin, kaempferol, chrysin, naringenin, genistein, rutin etc.) and terpenoids (artemisinin, taxol, digitoxin, azadarachtin, camphor, limonene etc.) (Takshak, 2018). These compounds have also gained importance in the area of nutraceuticals, which have positive health effects and may prove to be advantageous in the treatment of diseases like cancer, cardiovascular diseases and diabetes (Crozier et

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“…Several previous studies showed that natural compounds attenuated CSP testicular toxicity [26][27][28]. Some studies revealed that natural compounds provided more protective effect than synthetic compounds [26].…”

Section: Discussionmentioning

confidence: 99%

Nimesulide Inhibits MAPK/COX-2 Pathway, and Prevents Oxidative Stress, Inflammation, and Apoptosis in Testes of Cisplatin-Challenged Rats

Fouad

Khalaf

Akl

et al. 2020

JPRI

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The potential testicular protective effect of nimesulide (NSE) was studied in cisplatin (CSP)-challenged rats. NSE therapy (10 mg/kg/day, p.o.) was applied for 15 days, and a single dose of CSP (7 mg/kg, i.p.) was administered on the 10th day. CSP significantly decreased the levels of serum testosterone, testicular reduced glutathione, and superoxide dismutase. CSP also significantly increased testicular malondialdehyde, nitric oxide, tumor necrosis factor-α, interleukin-1β, cyclooxygenase-2 (COX-2), prostaglandin E2, nuclear factor-κB p65, Bax, and caspase-3. NSE significantly ameliorated all the biochemical changes observed in CSP-challenged rats. Moreover, NSE significantly reduced the histopathological injury, and the expressions of phosphorylated c-Jun N-terminal kinase (p-JNK) and p38 mitogen-activated protein kinases (MAPKs) in testes of rats received CSP. It was concluded that NSE significantly blocked the CSP-induced acute testicular injury in rats through inhibition of MAPK/COX-2 signaling pathway, and by combating oxidative stress, inflammation, and apoptosis.

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Ameliorative effects of rutin against cisplatin-induced reproductive toxicity in male rats

Cited by 63 publications

References 68 publications

Protective Role of Ficus carica Extract Against Hepato-Testicular Side Effects and Genotoxicity Induced by Cisplatin

Protective Role of Ficus carica Extract Against Hepato-Testicular Side Effects and Genotoxicity Induced by Cisplatin

A review on the chemistry and biological properties of Rutin, a promising nutraceutical agent

Nimesulide Inhibits MAPK/COX-2 Pathway, and Prevents Oxidative Stress, Inflammation, and Apoptosis in Testes of Cisplatin-Challenged Rats

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