Ameliorative effects of <scp><i>Magnolia sieboldii</i></scp> buds hexane extract on experimental reflux esophagitis

Li, Nan; Nam, Hyeon‐Hwa; Park, Byung Yong; Kim, Beom Tae; Choo, Byung-Kil

doi:10.1002/ptr.6689

Cited by 7 publications

(4 citation statements)

References 40 publications

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“…Many studies have reported the reaction cascade of a series of cellular infiltrations and cytokine release that results in an inflammatory response and damage in the esophageal tissue. 45 , 46 It is worth noting that HWJNG exerts protective effects via targets and pathways related to inflammatory response, which have been confirmed by network pharmacology analysis in the current study. It is also preliminarily confirmed HWJNG inhibits neuroinflammatory mediators and a key receptor of stimulation to reduce the stimulation of the esophageal mucosa.…”

Section: Discussionsupporting

confidence: 82%

Network Pharmacology Analysis of Hewei Jiangni Granule for Gastroesophageal Reflux Disease and Experimental Verification of Its Anti-Neurogenic Inflammation Mechanism

Cheng¹,

Kou²,

Zhang³

et al. 2022

DDDT

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Purpose Proton pump inhibitors, as the first-line drugs for treating gastroesophageal reflux disease (GERD), are unable to completely relieve patients’ symptoms and patients are prone to recurrence after prolonged drug withdrawal. Thus, it is crucial to find herbal medicines as a complementary and alternative treatment. Hewei Jiangni granule (HWJNG) is a classical Chinese medicinal formula with clinical therapeutic effects on GERD, but its pharmacological mechanism of action remains unclear. This study aimed to explore and then verify the pharmacological mechanisms of HWJNG in GERD therapy. Methods A network pharmacology approach was applied to explore and then verify the pharmacological mechanisms of HWJNG in GERD therapy. The active ingredients of HWJNG, as well as therapeutic targets of GERD were acquired from specialized databases. The “herb-ingredient-gene-target” network for HWJNG in GERD treatment was built. The protein–protein interaction (PPI) network was constructed to screen the core coincident targets. Then, gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed. The core targets and signaling pathways associated with the anti-neurogenic inflammatory effect were partially verified via experiments in vivo at molecular level. Results In total, 179 chemical ingredients in HWJNG and 298 intersection targets between GERD and HWJNG were selected from databases. A large proportion of core targets and top signaling pathways were involved in neurogenic inflammation. HWJNG significantly alleviated pathological injuries of esophagus and reversed dilated intracellular spaces. Additionally, HWJNG markedly inhibited the excessive release of inflammatory cytokines such as interleukin (IL)-1β, IL-6, tumor necrosis factor receptor (TNF-a), as well as regulated stimulation sensors including transient receptor potential vanilloid type 1 (TRPV1) and its related neuroinflammatory mediators in GERD mice. Conclusion HWJNG is a promising therapeutic strategy for GERD treatment via regulation of multiple targets and pathways, its effects in alleviating neurogenic inflammation are especially acknowledged.

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Section: Discussionsupporting

confidence: 82%

Network Pharmacology Analysis of Hewei Jiangni Granule for Gastroesophageal Reflux Disease and Experimental Verification of Its Anti-Neurogenic Inflammation Mechanism

Cheng¹,

Kou²,

Zhang³

et al. 2022

DDDT

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“…Our results are consistent with the recent findings highlighting the ability of Magnolia sieboldii buds extract to significantly protect esophageal tissue damage and downregulate inflammatory mediators. (Nan et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of an oral suspension containing xyloglucan and pea proteins on a murine model of gastroesophageal reflux disease

Ardizzone,

Mannino,

Casili

et al. 2024

Phytotherapy Research

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Gastroesophageal reflux disease (GERD) is the most common foregut disease, affecting about 20% of the adult population. Esophageal epithelial barrier plays a fundamental role in the pathophysiology of GERD; however, pharmacological therapies mainly aim to reduce the acidity of the gastroesophageal environment rather than to protect esophageal tissue integrity. This study aims to evaluate the efficacy of an oral solution containing xyloglucan and pea proteins (XP) in reestablishing gastroesophageal tissue integrity and biochemical markers. To induce GERD, C57BL/6 mice were alternatively overfed and fasted for 56 days and then treated with XP, sodium alginate, omeprazole, or omeprazole+XP twice daily for 7 days. Gastric pain and inflammatory markers were evaluated after 3 and 7 days of treatment. After sacrifice, the esophagi and stomachs were surgically removed for macroscopic and histological examination. Gastric pain was significantly reduced at days 3 and 7 by XP, omeprazole, and omeprazole+XP, while alginates were ineffective at day 3. XP was able to diminish gastric macroscopic damage and demonstrated the same efficacy as omeprazole in reducing esophageal damage. XP significantly reduced histological damage, with an efficacy comparable to that of omeprazole, but superior to alginates. Inflammatory markers were significantly reduced by XP, with superior efficacy compared with alginates at day 7. Interestingly, XP was also able to significantly increase gastric pH. This study demonstrated that XP restored gastric homeostasis, improved esophageal integrity, and decreased inflammation and pain with a similar efficacy to omeprazole and greater than alginates.

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“…Several reports have demonstrated that Magnolia officinalis ethanol or hexane extract possess several phenolic compounds (such as magnolol, honokiol) that can reduce the production of acidic gastric juice and inhibit the proton pump of gastric parietal cells. They also have antioxidation and anti-inflammation effects in an ethanol-induced gastric ulcer animal model [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…According to previous studies [ 6 , 7 ], Magnolia officinalis extracts were most commonly made with ethanol or hexane. In this study, we investigated the protective effects of a unique and patented Magnolia officinalis water extract on gastric mucosa epithelial cells in acidic medium and gastric ulcers induced by Shay's ulcer surgical method in ICR mice.…”

Section: Introductionmentioning

confidence: 99%

Efficiency and Mechanism Evaluation of Magnolia officinalis Water Extract in Preventing Gastric Ulcer

Shen

Chang

Hsieh

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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In this study we aimed at demonstrating the ability of Magnolia officinalis water extract to ameliorate gastric ulcers in in vitro and in vivo experiments. The gastric mucosa epithelial cell line, RGM 1, was pretreated with Magnolia officinalis water extract (0, 0.1, 1, 2, 5, or 10 mg/ml) and cultured in DMEM/F12 medium (pH 7.4) for 2 h and then in DMEM/F12 medium (pH 4.0) for 10 min. Magnolia officinalis water extract protected the cell viability and decreased reactive oxygen species formation by the acidic medium. In the in vivo experiment, Magnolia officinalis water extract (100 mg/kg) was administrated daily for 28 days in ICR mice via oral gavage, and then Shay’s ulcer surgical method was performed to induce gastric ulcers. We analyzed the pH value of stomach acid and the pathological section, inflammation, and cannabinoid receptor type 2 (CB2) cDNA levels of the stomach. Magnolia officinalis water extract not only enhanced the pH value of stomach acid but also ameliorated the ulcer index and inflammation and increased CB2 expression effectively. These results suggest that Magnolia officinalis water extract might be used to decrease the incidence of gastric ulcer.

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Ameliorative effects of Magnolia sieboldii buds hexane extract on experimental reflux esophagitis

Cited by 7 publications

References 40 publications

Network Pharmacology Analysis of Hewei Jiangni Granule for Gastroesophageal Reflux Disease and Experimental Verification of Its Anti-Neurogenic Inflammation Mechanism

Network Pharmacology Analysis of Hewei Jiangni Granule for Gastroesophageal Reflux Disease and Experimental Verification of Its Anti-Neurogenic Inflammation Mechanism

Efficacy of an oral suspension containing xyloglucan and pea proteins on a murine model of gastroesophageal reflux disease

Efficiency and Mechanism Evaluation of Magnolia officinalis Water Extract in Preventing Gastric Ulcer

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