Ameliorative effects of total coumarins from the fructus of <scp><i>Cnidium monnieri</i></scp> (L.) Cuss. on 2,4‐dinitrochlorobenzene‐induced atopic dermatitis in rats

Zhang, Yu; Deng, Ting; Wang, Ping; Sun, Tao; Xu, Ying

doi:10.1002/ptr.7052

Cited by 9 publications

(7 citation statements)

References 51 publications

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“…[Urticaceae; Laportea herba] is total coumarins, with a content of over 50% (Zhang et al, 2013). The study demonstrated that total coumarins improved the atopic dermatitis symptoms of rats through reducing the production of IL-4, thymic stromal lymphopoietin (TSLP), and IgE and suppressed the pruritus caused by TSLP, and histamine (Yu et al, 2021). Laportea bulbifera (Siebold & Zucc.)…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of Runzao Zhiyang capsule for chronic urticaria: a systematic review and meta-analysis of randomized controlled trials

Zhang,

Wang,

Lin

et al. 2023

Front. Pharmacol.

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Background: Chronic urticaria (CU) is a commonly seen skin disorder featured by recurring wheals, with or without angioedema, lasting for at least 6 weeks. Runzao Zhiyang capsule (RZC) has been widely applied to treat patients with CU. This study is aimed at systematically evaluating the efficacy and safety of RZC in treating CU.Materials and Methods: Randomized controlled trials (RCTs) of RZC on treating CU from Chinese and English databases were searched. Data were collected by two independent researchers. The Cochrane Collaboration tool was adopted for evaluating the risk of bias. The meta-analysis was performed with Review Manager 5.3 software. Sensitivity analysis and publication bias assessment were conducted by Stata 14.0 software.Results: Totally 27 studies were included in the analysis, involving 2,703 patients. The pooled results showed that compared with second-generation H1-antihistamines (sgAHs) therapy alone, RZC combined with sgAHs is more effective in improving the total effective rate (RR = 1.32, 95% CI: 1.25 to 1.39, p < 0.00001), the quality of life measured by Dermatology Life Quality Index (DLQI) (MD = −2.63, 95% CI: −3.68 to −1.58, p < 0.00001) and the serum IFN-γ level (SMD = 3.10, 95% CI: 1.58 to 4.62, p < 0.0001), and reducing the recurrence rate (RR = 0.39, 95% CI: 0.27 to 0.55, p < 0.00001), the serum total IgE level (SMD = −2.44, 95% CI: −3.51 to −1.38, p < 0.00001), the serum IL-4 level (SMD = −2.96, 95% CI: −4.10 to −1.83, p < 0.00001), and the incidence of adverse events including dizziness, fatigue, dry mouth, and constipation (RR = 0.53, 95% CI: 0.33 to 0.85, p = 0.009; RR = 0.46, 95% CI: 0.26 to 0.84, p = 0.01; RR = 0.57, 95% CI: 0.34 to 0.95, p = 0.03; RR = 0.24, 95% CI: 0.07 to 0.85, p = 0.03).Conclusion: The current evidence indicates that RZC may be an efficient therapeutic regimen in patients with CU. Nevertheless, owing to the suboptimal quality of the included studies, more large-scale, well-designed RCTs are required to verify the obtained findings.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/; Identifier: CRD42022313177.

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of Runzao Zhiyang capsule for chronic urticaria: a systematic review and meta-analysis of randomized controlled trials

Zhang,

Wang,

Lin

et al. 2023

Front. Pharmacol.

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“…Some of the most promising substances are coumarins from the fruit of Cnidium monnieri (TCFC), which possess evident biological activities based on their compounds. TCFC upregulated the filaggrin mRNA in the skin of rats, while it downregulated the levels of IL-1β, IL-4, IL-31, and TSLP mRNA [ 40 ]. Another aspect to consider is gut microbiota, since increasing studies have shown a close relationship between gut and skin health.…”

Section: Discussionmentioning

confidence: 99%

IL-31: State of the Art for an Inflammation-Oriented Interleukin

Borgia

Custurone

Pomi

et al. 2022

IJMS

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Interleukin 31 belongs to the IL-6 superfamily, and it is an itch mediator already studied in several diseases, comprising atopic dermatitis, allergic pathologies, and onco-hematological conditions. This research aims to assess the role of this cytokine in the pathogenesis of these conditions and its potential therapeutic role. The research has been conducted on articles, excluding reviews and meta-analysis, both on animals and humans. The results showed that IL-31 plays a crucial role in the pathogenesis of systemic skin manifestations, prognosis, and itch severity. Traditional therapies target this interleukin indirectly, but monoclonal antibodies (Mab) directed against it have shown efficacy and safety profiles comparable with biological drugs that are already available. Future perspectives could include the development of new antibodies against IL-31 both for humans and animals, thus adding a new approach to the therapy, which often has proven to be prolonged and specific for each patient.

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“…Moreover, some plant extracts such as resveratrol, rice components and P. densiflora bark extract have been shown to reduce IL-31 production topically by downregulating mRNA expression of Th2 and Th17 cytokines [157,158]. Other promising topical agents are the coumarins from the fruit of Cnidium monnieri (TCFC), which upregulated the filaggrin mRNA in the skin of rats and downregulated the levels of IL-1β, IL-4, IL-31 and TSLP mRNA [159].…”

Section: Therapeutic Approaches For Dysbiosis In Atopic Dermatitis An...mentioning

confidence: 99%

Microbiota and IL-33/31 Axis Linkage: Implications and Therapeutic Perspectives in Atopic Dermatitis and Psoriasis

et al. 2023

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Microbiome dysbiosis and cytokine alternations are key features of atopic dermatitis (AD) and psoriasis (PsO), two of the most prevalent and burdensome pruritic skin conditions worldwide. Interleukin (IL)-33 and IL-31 have been recognized to be major players who act synergistically in the pathogenesis and maintenance of different chronic inflammatory conditions and pruritic skin disorders, including AD and PsO, and their potential role as therapeutic targets is being thoroughly investigated. The bidirectional interplay between dysbiosis and immunological changes has been extensively studied, but there is still debate regarding which of these two factors is the actual causative culprit behind the aetiopathological process that ultimately leads to AD and PsO. We conducted a literature review on the Pubmed database assessing articles of immunology, dermatology, microbiology and allergology with the aim to strengthen the hypothesis that dysbiosis is at the origin of the IL-33/IL-31 dysregulation that contributes to the pathogenesis of AD and PsO. Finally, we discussed the therapeutic options currently in development for the treatment of these skin conditions targeting IL-31, IL-33 and/or the microbiome.

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Ameliorative effects of total coumarins from the fructus of Cnidium monnieri (L.) Cuss. on 2,4‐dinitrochlorobenzene‐induced atopic dermatitis in rats

Cited by 9 publications

References 51 publications

Efficacy and safety of Runzao Zhiyang capsule for chronic urticaria: a systematic review and meta-analysis of randomized controlled trials

Efficacy and safety of Runzao Zhiyang capsule for chronic urticaria: a systematic review and meta-analysis of randomized controlled trials

IL-31: State of the Art for an Inflammation-Oriented Interleukin

Microbiota and IL-33/31 Axis Linkage: Implications and Therapeutic Perspectives in Atopic Dermatitis and Psoriasis

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