Ameliorative mechanisms of turmeric-extracted curcumin on arsenic (As)-induced biochemical alterations, oxidative damage, and impaired organ functions in rats

Ishaq, Anam; Gulzar, Huma; Hassan, Ali; Kamran, Muhammad; Riaz, Muhammad; Parveen, Aasma; Chattha, Muhammad Sohaib; Walayat, Noman; Fatima, Sana; Afzal, Sobia; Fahad, Shah

doi:10.1007/s11356-021-15695-4

Cited by 20 publications

(11 citation statements)

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“…It was found in the experiment that the exposure of arsenic trioxide can cause oxidative stress [ 43 , 44 ]. In a rat model of liver and kidney injury induced by sodium arsenate, TC and LDL-C increased, meanwhile, it showed a significant reduction in activities of antioxidant markers such as superoxide dismutase (SOD) adn catalase (CAT) [ 45 ]. Both population and experimental results demonstrate that As promotes LDL oxidation, a key step in vascular inflammation and chronic vascular disease [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Linking the Low-Density Lipoprotein-Cholesterol (LDL) Level to Arsenic Acid, Dimethylarsinic, and Monomethylarsonic: Results from a National Population-Based Study from the NHANES, 2003–2020

Huang

2022

Nutrients

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Arsenic (As) contamination is a global public health problem. Elevated total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C) are risk factors for cardiovascular diseases, but data on the association of urinary arsenic species’ level and LDL-C are limited. We performed an association analysis based on urinary arsenic species and blood TC and LDL-C in US adults. Methods: Urinary arsenic, arsenic acid (AA), dimethylarsinic (DMA), monomethylarsonic (MMA), TC, LDL-C, and other key covariates were obtained from the available National Health and Nutrition Examination Survey (NHANES) data from 2003 to 2020. Multiple linear regression analysis and generalized linear model are used to analyze linear and nonlinear relationships, respectively. Results: In total, 6633 adults aged 20 years were enrolled into the analysis. The median total urinary arsenic level was 7.86 µg/L. A positive association of urinary arsenic concentration quartiles was observed with TC (β: 2.42 95% CI 1.48, 3.36). The OR for TC of participants in the 80th versus 20th percentiles of urinary total arsenic was 1.34 (95% CI 1.13, 1.59). The OR for LDL-C of participants in the 80th versus 20th percentiles of urinary total arsenic was 1.36 (95% CI 1.15, 1.62). For speciated arsenics analysis, the OR for arsenic acid and TC was 1.35 (95% CI 1.02, 1.79), whereas the OR for DMA and LDL-L was 1.20 (95% CI 1.03, 1.41), and the OR for MMA and LDL-L was 1.30 (95% CI 1.11, 1.52). Conclusions: Urinary arsenic and arsenic species were positively associated with increased LDL-C concentration. Prevention of exposure to arsenic and arsenic species maybe helpful for the control of TC and LDL-C level in adults.

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Section: Discussionmentioning

confidence: 99%

Linking the Low-Density Lipoprotein-Cholesterol (LDL) Level to Arsenic Acid, Dimethylarsinic, and Monomethylarsonic: Results from a National Population-Based Study from the NHANES, 2003–2020

Huang

2022

Nutrients

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“…The liver samples (washed with PBS (Sigma), and minced with scissors) were centrifuged after homogenization in the buffer solution (1.15% potassium chloride, pH=7.4, centrifuged in 4 o C for 15M/ 5000R), and the surface solution was used for measuring the activity of Glutathione peroxidase enzymes (GPX.L), Superoxide dismutase (SOD.L), and the level of Malondialdehyde (MAD.L). GPX.L activity and SOD.L were measured using the method applied by Ishaq et al (2021) The statistical analysis of data was analysed using GLM software (9.1) SAS, and the mean levels were compared with the Tukey method (P ≥0.05) (SAS, 2008). The statistical model of the design was as follows:…”

Section: Methodsmentioning

confidence: 99%

Comparison of nano-capsulated thyme essential oils on intestinal microbial population and anti-oxidation status of broilers

Ardabili

Nobakht

Safamehr

et al. 2022

J Hellenic Vet Med Soc

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This study was conducted to evaluate the effects of non and nano-capsulated thyme essential oils with saturated and unsaturated lipids (tallow and canola oil) and two levels of diet crude protein (standard and low than standard) on intestinal microbial population and anti-oxidation status of broilers. In this study, 384 Ross-308 broiler chickens in a factorial engagement of 2×2×2 (2 medicinal plant essential oils, two sources of vegetable oils, and 2 levels of diet crude protein) were used in a completely randomized design with 8 treatments, 4 replicates, and 12 bird in each replicate for 42 days. Experimental periods included starter (1-10 days), grower (11-24 days), and finisher (25-42 days). Canola oil significantly reduced the intestinal coliforms population. In contrast, tallow increased them (P<0.05), a similar effect was observed with thyme forms, so the lowest coliform population blogged to the nano-capsulated form of thyme. In contrast, the highest coliform population resulted in non-capsulated thyme essential oil (P<0.05). In an interaction between thyme essential oil form and diet crude protein level, the lowest coliform population was observed with diet contained nano-capsulated thyme essential oil and low level of diet crude protein (P<0.05). Regarding antioxidant status, reducing the diet crude protein increased MDA and GPX (P<0.05). In an interaction between diet crude protein and thyme form, a diet with low crude protein and capsulated thyme increased the level of SOD (P<0.05). In general, results of the current experiment indicated that in Ross-308, broiler chickens using capsulated thyme essential oil with canola oil and low crude protein improves intestine microbial population and antioxidant status of broilers.

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“…The presence of a lone pair of electrons in polyphenolic compounds and thiol groups in sulfur-containing phytochemicals are possible mechanisms behind their ability to chelate arsenic. Thus, curcumin, , rutin, quercetin, chrysin, and allicin have been reported to reduce arsenic load in different target organs. Further, concomitant use of polyphenolic compounds with synthetic chelators results in the reduced adverse effects with synthetic chelators.…”

Section: Probable Protective Mechanisms Of Phytochemicals In Arsenic ...mentioning

confidence: 99%

Phytochemicals in the Management of Arsenic Toxicity

Khan

Sharma

Flora

2022

Chem. Res. Toxicol.

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Arsenic toxicity is a major concern due to its deleterious consequences for human health. Rapid industrialization also has weakened the quality of the environment by introducing pollutants that may disrupt balanced ecosystems, adversely and irreversibly impacting humans, plants, and animals. Arsenic, an important toxicant among all environmental hazards, can lead to several detrimental effects on cells and organs, impacting the overall quality of life. Nevertheless, arsenic also has a rich history as a chemotherapeutic agent used in ancient days for the treatment of diseases such as malaria, cancer, plague, and syphilis when other chemotherapeutic agents were yet to be discovered. Arsenicosis-mediated disorders remain a serious problem due to the lack of effective therapeutic options. Initially, chelation therapy was used to metabolically eliminate arsenic by forming a complex, but adverse effects limited their pharmacological use. More recently, plant-based products have been found to provide significant relief from the toxic effects of arsenic poisoning. They act by different mechanisms affecting various cellular processes. Phytoconstituents such as curcumin, quercetin, diallyl trisulfide, thymoquinone, and others act via various molecular pathways, primarily by attenuating oxidative damage, membrane damage, DNA damage, and proteinopathies. Nonetheless, most of the phytochemicals reviewed here protect against the adverse effects of metal or metalloid exposure, supporting their consideration as alternatives to chelation therapy. These agents, if used prophylactically and in conjunction with other chemotherapeutic agents, may provide an effective approach for management of arsenic toxicity. In a few instances, such strategies like coadministration of phytochemicals with a known chelating agent have led to more pronounced elimination of arsenic from the body with lesser off-site adverse effects. This is possible because combination treatment ensures the use of a reduced dose of chelating agent with a phytochemical without compromising treatment. Thus, these therapies are more practical than conventional therapeutic agents in ameliorating arsenic-mediated toxicity. This review summarizes the potential of phytochemicals in alleviating arsenic toxicity on the basis of available experimental and clinical evidence.

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Ameliorative mechanisms of turmeric-extracted curcumin on arsenic (As)-induced biochemical alterations, oxidative damage, and impaired organ functions in rats

Cited by 20 publications

References 87 publications

Linking the Low-Density Lipoprotein-Cholesterol (LDL) Level to Arsenic Acid, Dimethylarsinic, and Monomethylarsonic: Results from a National Population-Based Study from the NHANES, 2003–2020

Linking the Low-Density Lipoprotein-Cholesterol (LDL) Level to Arsenic Acid, Dimethylarsinic, and Monomethylarsonic: Results from a National Population-Based Study from the NHANES, 2003–2020

Comparison of nano-capsulated thyme essential oils on intestinal microbial population and anti-oxidation status of broilers

Phytochemicals in the Management of Arsenic Toxicity

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