Ameliorative potential of Psidium guajava in induced arsenic toxicity in Wistar rats

Roy, Manju; Roy, Sushovan

doi:10.5455/vetworld.2011.82-83

Cited by 4 publications

(3 citation statements)

References 4 publications

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“…Consistent with the studies reported in this study, it was determined that the rats in the arsenic-treated group had the highest K (p˂0.05) and Na (numerically, p>0.05) levels and that sodium arsenite could cause imbalances in electrolyte levels due to impaired kidney function. Roy and Roy (2011) found that serum phos- : Different letters in the same row mark statistical difference between values. (p<0.05).…”

Section: Discussionmentioning

confidence: 99%

Investigation of the protective effect of chitosan against arsenic-induced nephrotoxicity and oxidative damage in rat kidney tissue

İrak,

Çelik,

Bolacalı

et al. 2024

Polish Journal of Veterinary Sciences

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Arsenic is an important metalloid that can cause poisoning in humans and domestic animals. Exposure to arsenic causes cell damage, increasing the production of reactive oxygen species. Chitosan is a biopolymer obtained by deacetylation of chitin with antioxidant and metal ion chelating properties. In this study, the protective effect of chitosan on arsenic-induced nephrotoxicity and oxidative damage was investigated. 32 male Wistar-albino rats were divided into 4 groups of 8 rats each as control group (C), chitosan group (CS group), arsenic group (AS group), and arsenic+chitosan group (AS+CS group). The C group was given distilled water by oral gavage, the AS group was given 100 ppm/day Na-arsenite ad libitum with drinking water, the CS group was given 200 mg/kg/day chitosan dissolved in saline by oral gavage, the AS+CS group was given 100 ppm/day Na-arsenite ad libitum with drinking water and 200 mg/kg/day chitosan dissolved in saline by oral gavage for 30 days. At the end of the 30-day experimental period, 90 mg/kg ketamine was administered intraperitoneally to all rats, and blood samples and kidney tissues were collected. Urea, uric acid, creatinine, P, Mg, K, Ca, Na, Cystatin C (CYS-C), Neutrophil Gelatinase Associated Lipocalin (NGAL) and Kidney Injury Molecule 1 (KIM-1) levels were measured in serum samples. Malondialdehyde (MDA), Glutathione (GSH), Catalase (CAT) and Superoxide dismutase (SOD) levels in the supernatant obtained from kidney tissue were analyzed by ELISA method. Compared with AS group, uric acid and creatinine levels of the AS+CS group were significantly decreased (p<0.001), urea, KIM-1, CYS-C, NGAL, and MDA levels were numerically decreased and CAT, GSH, and SOD levels were numerically increased (p>0.05). In conclusion, based on both biochemical and histopathological-immunohistochemical- immunofluorescence findings, it can be concluded that chitosan attenuates kidney injury and protects the kidney.

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Section: Discussionmentioning

confidence: 99%

Investigation of the protective effect of chitosan against arsenic-induced nephrotoxicity and oxidative damage in rat kidney tissue

İrak,

Çelik,

Bolacalı

et al. 2024

Polish Journal of Veterinary Sciences

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“…Maintains the cellular integrity of testicular cells and improves sperm quality parameters in rats [126] Ipomea aquatica Amelioration of antioxidant parameters in liver, kidney, heart, brain and testis in mice [127] Tamarindus indica Regulation of serum hepatic and oxidative stress markers in rats [128] Triticum aestivum…”

Section: Withania Somniferamentioning

confidence: 99%

“…A large number of researches confirmed the beneficial effect of Glycine max [122], Sesamum indicum [123], Satureja hortensis [124] Withania somnifera [125,126], Ipomea aquatica [127], Tamarindus indica [128], Royal jelly [129], and Terminalia chebula [130] on arsenic and cadmium toxicities reduction. Concerning the effects of natural products on arsenic toxicity in ruminants, it was reported that Curcuma longa, Zingiber officinale, and Amaranthus spinosus have eliminated the absorption of arsenic from the bovine body and protected against DNA fragmentation in these species [131,132].…”

Section: Arsenic and Cadmium Toxicity Preventionmentioning

confidence: 99%

Mitigating Fluoride, Lead, Arsenic and Cadmium Toxicities in Laboratory Animals and Ruminants through Natural Products

Rahim¹,

Aydoğmuş-Öztürk²,

Çakir³

et al. 2022

Rec. Agric. Food. Chem

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Environmental pollutants are considered a serious health problem for humans and animals mainly ruminants in several regions of the world. Previously, many studies have investigated the mechanisms of toxicity of these pollutants on laboratory animals. Afterward, other studies have demonstrated that exposure to environmental pollutants may cause several adverse effects on the ruminant organs, influencing its performance and leading to socio-economic problems for breeders. Fluoride, lead, arsenic, and cadmium are the most common poisonings in ruminants, they can cause several irreversible toxic effects in many organs depending on the mode of action. The adverse effects of fluoride, lead, arsenic, and cadmium toxicities in laboratory animals and ruminants have been clearly summarized in this review. In addition, several results on protective or ameliorative effects by means of natural products against these toxicities in laboratory animals and ruminants have been illustrated.

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Herbal Options for Arsenic Toxicity Mitigation: An Appraisal

Bhattacharya

2023

Environmental Science and Engineering

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Ameliorative potential of Psidium guajava in induced arsenic toxicity in Wistar rats

Cited by 4 publications

References 4 publications

Investigation of the protective effect of chitosan against arsenic-induced nephrotoxicity and oxidative damage in rat kidney tissue

Investigation of the protective effect of chitosan against arsenic-induced nephrotoxicity and oxidative damage in rat kidney tissue

Mitigating Fluoride, Lead, Arsenic and Cadmium Toxicities in Laboratory Animals and Ruminants through Natural Products

Herbal Options for Arsenic Toxicity Mitigation: An Appraisal

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