Ameliorative Potentials of Methanol Extract and Chloroform Fraction of Drymaria cordata on MSG-induced Uterine Hyperplasia in Female Wistar Rats

Olowofolahan, Adeola Oluwakemi; Aina, Oluwasanmi Olayinka; Hassan, Elfatih A.; Olorunsogo, O. O.

doi:10.9734/ejmp/2017/36335

Cited by 11 publications

(4 citation statements)

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“…There was also a significant (P < 0.05) increase in progesterone levels in PC compared to NC (Figure 1). This may be due to an increase in luteinizing hormone as a result of MSG treatment 29 . These results concur with the findings of Zia et al 46 and Olowofolahan et al 29 , who reported increased progesterone levels in the plasma of MSGtreated animals.…”

Section: Discussionmentioning

confidence: 99%

“…This may be due to an increase in luteinizing hormone as a result of MSG treatment 29 . These results concur with the findings of Zia et al 46 and Olowofolahan et al 29 , who reported increased progesterone levels in the plasma of MSGtreated animals. Treatment with the ethanol extract of Diodia sarmentosa (Sw) leaves reduced the elevated estrogen and progesterone levels in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Uterine fibroids were induced with a single daily dose of 200 mg monosodium glutamate (MSG)/kg over 30 days using an oral gavage tube, with slight modifications to the protocol described by Olowofolahan et al 29 . At the end of the induction period, representative samples of the uterus were harvested from the three experimental groups and processed using histological techniques and routine Hematoxylin and Eosin (H&E) staining to confirm successful induction of tumors before the commencement of treatment.…”

Section: Tumor Inductionmentioning

confidence: 99%

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Effects of ethanol extracts of Diodia sarmentosa leaves on biochemical and histopathological indices of monosodium glutamate-induced uterine leiomyoma in rats

Ezejiofor

Okoroafor

2022

Biomed. Res. Ther.

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Background: Diodia sarmentosa leaves have gained application in the local treatment of certain ailments. This study evaluated the effect of ethanol extracts of Diodia sarmentosa leaves on biochemical, antioxidant, and histopathological indices of monosodium glutamate-induced uterine leiomyoma in albino rats. Methods: Twenty-one (21) female adult albino rats were acclimatized for 10 days and then classified into three treatment groups, each containing seven rats. Group 1 was the normal control (NC) without any induction, Group 2 was the positive control (PC) and was induced with 200 mg/kg body weight of monosodium glutamate (MSG) without treatment, and Group 3 was the treated group (TG), induced with 200 mg/kg body weight of MSG, then treated with 400 mg/kg body weight of ethanol extract of Diodia sarmentosa leaves for 30 days. Results:The results of the study showed an impaired antioxidant system in the positive control (untreated group). Some biochemical parameters were also altered in the positive control, mostly revealing a relationship between uterine leiomyoma and renal impairment, or kidney damage. Treatment with ethanol extracts of Diodia sarmentosa leaves significantly (P < 0.05) improved the altered biochemical and antioxidant parameters. These findings were also supported by a histopathology result, which revealed the extent of tumors in the affected tissues. Conclusion: The ethanol extract of Diodia sarmentosa (Sw) leaves mitigated oxidative stress and improved the impaired antioxidant system caused by uterine leiomyoma induction.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Tumor Inductionmentioning

confidence: 99%

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Effects of ethanol extracts of Diodia sarmentosa leaves on biochemical and histopathological indices of monosodium glutamate-induced uterine leiomyoma in rats

Ezejiofor

Okoroafor

2022

Biomed. Res. Ther.

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“…4 Monosodium glutamate (MSG) is a salt of glutamate, synthesized from L-glutamic acid and used as a flavour enhancer in foods. 1 Though MSG improves taste stimulation and enhances appetite, findings revealed that it is toxic to human and experimental animals. 2 MSG has a toxic effect on the testis by causing a significant oligozoospermia and increase abnormal sperm morphology in a dose dependent manner in male Wistar rats.…”

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confidence: 99%

Effects of hydro-alcohol extract of mistletoe leaves on changes in body-weight, uterus-weight, right ovary and liver in female rats

et al. 2022

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Background: Most people across rural areas in Africa depends of phytomedicine for the treatment of various diseases. This study aims to evaluate the impact of hydro-alcohol extract of mistletoe leaves on changes in body-weight, uterus-weight, ovary and liver of female Wistar rats.Methods: Forty-nine female rats were randomly selected into nine groups with five rats per group. Group 1 received 5 ml/kg of water, group 2 received mono sodium glutamate (MSG) 800 mg/kg, group 3 received extract 100 mg/kg, group 4 received extract 200 mg/kg, group 5 received extract 400 mg/kg, group 6 received extract 100 mg/kgand MSG 800 mg/kg, group 7 received extract 200 mg/kgand MSG 800vmg/kg, group 8 received extract 400 mg/kg and MSG 800 mg/kg and group 9 received letrozole 0.6 mg/kg and MSG 800 mg/kg. Administration of extract was done for 28 days.Results: Findings from the study revealed significance decreased in the final weight of the animals. When treated groups received extract “100 mg/kg, extract 200 mg/kg, extract 400 mg/kg, and extract 200 mg/kg and MSG 800 mg/kg”, it shows significance decreased in body weight difference. The results also show significance increased in the weight of the right ovary in the treated groups extract 100 mg/kg, extract 100 mg/kg and MSG 800 mg/kg. Extract 100 mg/kg, extract 400 mg/kg and MSG 800 mg/kg and letrozole 0.6 mg/kg and MSG 800 mg/kg, shows significance decreased in the weight of the uterus. MSG 800 mg/kg, “extract 100 mg/kg, extract 200 mg/kg, and extract 400 mg/kg”, it shows significance decreased in the weight of the liver. Statistical analysis was done using statistical package for the social sciences (SPSS) version 23 and p<0.05 was significant.Conclusions: There was significance decreased in rat’s body weight and significant increase in the right ovary when a lower dose of the extract was given and this increase could be due to MSG. The uterus significantly decreases when low dose of the extract was administered and the liver organ also has significant decreased in all the groups treated with extract alone.

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Monosodium Glutamate Induces Cytotoxicity in Rat Liver via Mitochondrial Permeability Transition Pore Opening

Olowofolahan

Adeosun

Olorunsogo

2020

Cell Biochem Biophys

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Ameliorative Potentials of Methanol Extract and Chloroform Fraction of Drymaria cordata on MSG-induced Uterine Hyperplasia in Female Wistar Rats

Cited by 11 publications

References 0 publications

Effects of ethanol extracts of Diodia sarmentosa leaves on biochemical and histopathological indices of monosodium glutamate-induced uterine leiomyoma in rats

Effects of ethanol extracts of Diodia sarmentosa leaves on biochemical and histopathological indices of monosodium glutamate-induced uterine leiomyoma in rats

Effects of hydro-alcohol extract of mistletoe leaves on changes in body-weight, uterus-weight, right ovary and liver in female rats

Monosodium Glutamate Induces Cytotoxicity in Rat Liver via Mitochondrial Permeability Transition Pore Opening

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