2024
DOI: 10.9734/ajrb/2024/v14i2281
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Ameliorative Potentials of Persea americana Mill (Avocado) Seed Extract on Acetaminophen-induced Hepatic Insufficiency in Rats

Enyinnaya A. Ogbonnaya,
Donatus C. Belonwu,
Ogechukwu E. Ezim
et al.

Abstract: Aim: The ability of ethylacetate extract of Persea americana Mill (avocado) seed to ameliorate the hepatotoxic effect of acetaminophen in rats was assessed. Methodology: Thirty experimental rats were placed in 6 groups of 5 animals per group. Two animal groups received distilled water and the drug vehicle, dimethyl sulphoxide (DMSO). Four other groups received acetaminophen (750 mg/kg bw/day) in DMSO for 3 days with 3 of the 4 groups receiving, after 3 days of acetaminophen administration and for 11 days, Pers… Show more

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