Ameliorative role of thymoquinone against reprotoxic effect caused by potassium bromate in female mice

Patel, Neetu; Shrivastava, Renu; Shrivastava, Vinoy K.

doi:10.1007/s00580-023-03458-1

Cited by 1 publication

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“…Certain quantities of potassium bromate residue are unsuitable for bread due to its poisonous and carcinogenic effects; as a result, it is prohibited in several countries [5] potassium bromate stimulated oxidative stress and caused damage in many organ systems such as liver and kidney [6]. Reproductive toxicity caused by KBrO 3 alters the hormonal and histo-morphological factors [7]. Health organizations began restricting potassium bromate because it is a potent oxidizing and hazardous agent to both human and animal organs.…”

Section: Introductionmentioning

confidence: 99%

Testicular Tissue Injury and Sperms Abnormalities Induced by Potassium Bromate and the Ameliorative Effect of Sesame Oil in Male Rats

Ali Jasim

2024

IOP Conf. Ser.: Earth Environ. Sci.

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The potassium bromate is one of the food additives, mostly it used in bakeries as flour improver and dough conditioner. It is a nephrotoxic in humans and probable carcinogenic in human and rats. Depending on its duration of exposure and dose, it employs a various degree of toxicity consumed with food and water in the many organisms. The study was conducted to investigate about harmful and toxic effects of potassium bromate in addition, the protective role of sesame oil in male rats. The criteria for assessment measured through sperms head and tail abnormality rate, histopathological, and relative testes organ weight. Thirty-two male rats (Rattus norvegicus) were used, the animals were separated in to four groups; each group consisted of eight animals. The first group treated distilled water considered a control, second group treated by sesame oil (4 ml/kilogram of body weight), the third group received about (12 mg of potassium bromate per one kilogram of body weight) and the fourth group received potassium bromate and sesame oil for 21 days. This study indicated significant increment p≤0.05 in the rate of sperm head and tail abnormality in group treated with potassium bromate and group treated with potassium bromate plus sesame oil as comparison with controls. In addition, the results identified significant decrement p≤0.05 of sperm head and tail abnormality rate in animal group treated with potassium bromate plus sesame oil when they were compared with group treated by potassium bromate alone. Additionally, the research identified damages in testes tissues of potassium bromate treated group and potassium bromate plus sesame oil group compared with controls. The study also indicated slightly histopathological damages in testes tissue in group was administrated potassium bromate plus sesame oil compared with group which was administrated potassium bromate only. The results reported significant decrement p≤0.05 of relative testes weight in animal group that was treated by potassium bromate, potassium bromate plus sesame oil compared by controls. Additionally, the results showed the positive role of sesame oil in significantly p≤0.05 enhancing KBrO3 affecting relative testes weight.

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Section: Introductionmentioning

confidence: 99%

Testicular Tissue Injury and Sperms Abnormalities Induced by Potassium Bromate and the Ameliorative Effect of Sesame Oil in Male Rats

Ali Jasim

2024

IOP Conf. Ser.: Earth Environ. Sci.

View full text Add to dashboard Cite

show abstract

Ameliorative role of thymoquinone against reprotoxic effect caused by potassium bromate in female mice

Cited by 1 publication

References 50 publications

Testicular Tissue Injury and Sperms Abnormalities Induced by Potassium Bromate and the Ameliorative Effect of Sesame Oil in Male Rats

Testicular Tissue Injury and Sperms Abnormalities Induced by Potassium Bromate and the Ameliorative Effect of Sesame Oil in Male Rats

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