Ameloblastic fibrosarcoma of the mandible: report of two cases and review of the literature

Abstract

Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumour. To date, 60 well-documented cases have been published in the English-language literature. Two additional cases located in the posterior region of the mandible are reported. The relevant clinicopathological features of these cases, as well as those previously reported are discussed. Approximately two-thirds of AFS are malignant tumors de novo, with an average age of the affected patients being 22.9 years. This age is lower than the one observed in AFS developing from a pre-existent benign lesion (mean 33 years). Although regional and distant metastases are very infrequent, AFS is a locally aggressive lesion, with 23 (37%) of the reported cases having at least one recurrence; 12 patients (19.3%) died of the disease. Wide surgical excision with long-term follow-up remains the treatment of choice for this neoplasm.

Ameloblastic fibro-odontosarcoma of the mandible: imaging findings

“…Only 1 out of 16 cases had metastasis to mediastinal node and liver. 16,[19][20][21][22] In conclusion, we reported the radiographic and histological aspects of a new case of AFOS. Although uncommon, AFOS should be considered in the differential diagnosis of intraoral radiolucencies with poorly circumscribed outlines that contain radiopaque material.…”

Ameloblastic fibrosarcoma of the mandible: case report and literature review

“…Ameloblastic fibrosarcoma most often occurs in patients around 30 years of age [1], but reported cases include those of patients ranging from 4 months to 78 years of age. It is most common in the mandible (79% cases [4]), predominantly in its posterior part [2,5].…”

“…It represents <5% of all odontogenic tumors [2,4]. In 2015, only 72 cases were reported in English literature [2].…”

“…Ameloblastic fibrosarcoma is a locally aggressive, rare malignant odontogenic tumor [1][2][3][4]. It represents <5% of all odontogenic tumors [2,4].…”

Ameloblastic Fibrosarcoma: A Case Report and Literature Review

“…(4-6,9-13,16-113). Papers describing clinicopathological features similar to those described for AFS were included in the first instance (4,5,(9)(10)(11)(12)(13)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(28)(29)(30)32,(34)(35)(36)(37)(38)(39)42,43,(67)(68)(69)(70)(71)(72)(74)(75)(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)91,…”