“…Furthermore, it differs from AM in terms of its rapid growth, cortical perforation, pain, and sensory abnormalities ( 11 ). AMCa usually develops de novo , but it can also occur in benign ameloblastoma that has been long-existing, untreated, or recurred ( 11 ). Histologically, AMCa is similar to AM in that it mainly presents as a stellate reticular central epithelium and surrounding basal palisade cells, with opposite nuclear polarity; However, AMCa also has obvious malignant features, such as cellular atypia, nuclear hyperchromatic, and increased mitotic activity ( 12 , 13 ).…”