Ameloblastoma Management: “Horses for Courses” Protocol

Menon, Suresh; Kumar, Veerendra; Shrivastava, Archana; Nath, Priyangana; Shivakotee, Satyapriya; Hoda, Mahbubul

doi:10.1007/s12663-019-01189-x

Cited by 4 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite its histologically benign features and a low metastatic potential, canine acanthomatous ameloblastoma (CAA) exhibits locally invasive behavior with a tendency to infiltrate adjacent structures including the jawbone, similar to human ameloblastoma (AM) 3 – 7 . Although e n bloc surgical excision is the current treatment of choice that allows long-term remission 4 – 7 , this is a technically complex and invasive procedure that often results in patient disfigurement and dysfunction 8 – 10 . By contrast, radiation therapy and marginal excision are less invasive options but are associated with a higher rate of persistence and recurrence 11 – 14 .…”

Section: Introductionmentioning

confidence: 99%

Comparative transcriptional profiling of canine acanthomatous ameloblastoma and homology with human ameloblastoma

Peralta

Duhamel

Katt

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Ameloblastomas are odontogenic tumors that are rare in people but have a relatively high prevalence in dogs. Because canine acanthomatous ameloblastomas (CAA) have clinicopathologic and molecular features in common with human ameloblastomas (AM), spontaneous CAA can serve as a useful translational model of disease. However, the molecular basis of CAA and how it compares to AM are incompletely understood. In this study, we compared the global genomic expression profile of CAA with AM and evaluated its dental origin by using a bulk RNA-seq approach. For these studies, healthy gingiva and canine oral squamous cell carcinoma served as controls. We found that aberrant RAS signaling, and activation of the epithelial-to-mesenchymal transition cellular program are involved in the pathogenesis of CAA, and that CAA is enriched with genes known to be upregulated in AM including those expressed during the early stages of tooth development, suggesting a high level of molecular homology. These results support the model that domestic dogs with spontaneous CAA have potential for pre-clinical assessment of targeted therapeutic modalities against AM.

show abstract