Amended Safety Assessment of <i>Hypericum Perforatum</i>-Derived Ingredients as Used in Cosmetics

Becker, Lillian C.; Bergfeld, Wilma F.; Belsito, D.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James G.; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Andersen, F. Alan

doi:10.1177/1091581814533354

Cited by 11 publications

(5 citation statements)

References 65 publications

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“…Photosensitization was reported for the topical use of St. John’s Wort in some studies [51, 89, 90]. On the other hand a recent safety assessment excerted by the Cosmetic Ingredient Review Expert Panel stating that St. John’s Wort as used in cosmetic emulsions is rather safe [91]. One reference included in this short review tested a bath oil containing St. John’s Wort on human skin and found it to be less irritating than other tested bath oils and sodium lauryl sulfate.…”

Section: Discussionmentioning

confidence: 99%

Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review

et al. 2019

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Background Medicinal plants have been used traditionally since centuries for wound care and treatment of skin diseases both in human and animals. Skin diseases are one of the most common reasons for owners to take their dog to the veterinarian. The demands for treatment and prophylaxis of these diseases are broad. A wide range of bacteria including antibiotic-resistant bacteria can be involved, making the treatment challenging and bear an anthropo-zoonotic potential. The aim of this review is to systematically evaluate based on recent scientific literature, the potential of four medicinal plants to enrich the therapeutic options in pyoderma, canine atopic dermatitis, otitis externa, wounds and dermatophytosis in dogs. Results Based on four books and a survey among veterinarians specialized in phytotherapy, four medicinal plants were chosen as the subject of this systematic review: Calendula officinalis L. (Marigold) , Hypericum perforatum L. agg. (St. John’s Wort) , Matricaria chamomilla L. (syn. Matricaria recutita L., Chamomile) and Salvia officinalis L. (Sage). According to the PRISMA statement through literature research on two online databases a total of 8295 publications was screened and narrowed down to a final 138 publications for which full-text documents were analyzed for its content resulting in a total of 145 references (21 clinical, 24 in vivo and 100 in vitro references). Conclusions All four plants were proven to have antibacterial and antifungal effects of a rather broad spectrum including antibiotic-resistant bacteria. This makes them an interesting new option for the treatment of pyoderma, otitis externa, infected wounds and dermatophytosis. Marigold, St. John’s Wort and Chamomile showed wound-healing properties and are thus promising candidates in line to fill the therapeutic gap in canine wound-healing agents. St. John’s Wort and Chamomile also showed anti-inflammatory and other beneficial effects on healthy skin. Due to the wide range of beneficial effects of these medicinal plants, they should be taken into account for the treatment of dermatologic diseases in dogs at least in future clinical research. Electronic supplementary material The online version of this article (10.1186/s12917-019-1854-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review

et al. 2019

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“…Hypericin, pseudohypericin, hyperforin, quercetin, and isorhamnetin increased in the plasma level after oral administration of H. perforatum extract. Furthermore, hyperforin is detected in human breast milk but not in infant plasma from mothers consuming H perforatum extract (Becker et al, 2014).…”

Section: H Perforatum L Toxicitymentioning

confidence: 99%

The potential role of Hypericum perforatum in wound healing: A literature review on the phytochemicals, pharmacological approaches, and mechanistic perspectives

Farasati Far,

Gouranmohit,

Naimi‐jamal

et al. 2024

Phytotherapy Research

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St. John's Wort, commonly known as Hypericum perforatum L., is a flowering plant in the Clusiaceae family that traditionally been employed for treating anxiety, depression, wounds, burns, sunburn, irritation, and stomach ailments. This review provides a synopsis of H. perforatum L. phytoconstituents and their biological effects, highlighting its beneficial therapeutic properties for dermatological indications, as well as its antioxidant, antimicrobial, anti‐inflammatory, and anti‐angiogenic activity in various applications including wound healing and skin conditions such as eczema, sun burn and minor burns also spastic paralysis, stiff neck and mood disorders as anti‐depressant and nerve pains such as neuralgia. The data were collected from several databases as Web of Science PubMed, ScienceDirect, Scopus and Google Scholar using the terms: “H. perforatum L.”, “H. perforatum L. /phytochemistry,” and “H. perforatum extracts/wound healing” collected from 1994 to 2023. The findings suggest H. perforatum L. acts through various mechanisms and plays a role in each phase of the wound healing process, including re‐epithelialization, angiogenesis, wound contraction, and connective tissue regeneration. H. perforatum L. enhances collagen deposition, decreases inflammation, inhibits fibroblast migration, and promotes epithelialization by increasing the number of fibroblasts with polygonal shape and the number of collagen fibers within fibroblasts. H. Perforatum L. extracts modulate the immune response and reduce inflammation were found to accelerate the wound healing process via inhibition of inflammatory mediators' production like interleukin‐6, tumor necrosis factor‐α, cyclooxygenase‐2 gene expression, and inducible nitric oxide synthase. Thus, H. perforatum L. represents a potential remedy for a wide range of dermatological problems, owing to its constituents with beneficial therapeutic properties. H. perforatum L. could be utilized in the development of novel wound healing therapies.

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“…A remarkable study on the use of the plant in cosmetics was published in 2014. Both the methods of use and the points to be considered are discussed in a very broad scope (135).…”

Section: Medicinal Usesmentioning

confidence: 99%

Recent Studies on Antioxidant, Antimicrobial, and Ethnobotanical Uses of Hypericum perforatum L. (Hypericaceae)

Yılmazoğlu

Hasdemir

2022

Journal of the Turkish Chemical Society Section A: Chemistry

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Hypericum perforatum L. (Hypericaceae) is one of the medicinal plants whose value has increased rapidly in recent years. It is especially popular for its use in the treatment of mild and moderate depression, as well as for the treatment of skin diseases, internal and external inflammatory wounds, neurological disorders, and the metabolism-disrupting effects of free radicals. Besides, it shows inhibitory effects against different kinds of microorganisms such as bacteria, fungus, and protozoa. Antimicrobial biofilms generated by the plant are its most potent output, unlike its essential oil which does not have much value in itself as much as its ingredients that can be converted into more valuable products. Its usage as a folk remedy has a wide application area in various cultures. It is thought that compiling studies on various aspects of this plant will benefit future studies. The present paper reports on studies on the antibacterial, antioxidant, and therapeutic properties of Hypericum perforatum, as well as on the composition of its essential oil.

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Amended Safety Assessment of Hypericum Perforatum-Derived Ingredients as Used in Cosmetics

Cited by 11 publications

References 65 publications

Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review

Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review

The potential role of Hypericum perforatum in wound healing: A literature review on the phytochemicals, pharmacological approaches, and mechanistic perspectives

Recent Studies on Antioxidant, Antimicrobial, and Ethnobotanical Uses of Hypericum perforatum L. (Hypericaceae)

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