American Association Of Clinical Endocrinologists, American College Of Endocrinology, And Androgen Excess And Pcos Society Disease State Clinical Review: Guide To The Best Practices In The Evaluation And Treatment Of Polycystic Ovary Syndrome - Part 2

Goodman, Neil F.; Cobin, Rhoda H.; Futterweit, Walter; Glueck, Jennifer S.; Legro, Richard S.; Carmina, Enrico

doi:10.4158/ep15748.dscpt2

Cited by 323 publications

(210 citation statements)

References 76 publications

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“…That weight loss as little as 5-10% of body weight can regularize menses and improve response to ovulation induction and fertility medications [9,12].…”

Section: Weight Reduction and Ovulation Inductionmentioning

confidence: 99%

“…Scientific studies have not confirmed that women could regain spontaneous ovulation with voluntary weight loss and other life style modifications as systematic reviews did not identify studies that confirm that ovulation and other clinical reproductive outcomes improved with weight loss in women with PCOS but the studies identified increased total testosterone, androgen index, hirsute, fasting blood glucose, fasting insulin, and worsened lipid profile in the obese women compared with normal weight women with PCOS [7][8][9]. Obesity is linked to anolution and pregnancy loss as well as poor response with ovulation induction methods such as clomiphene citrate, gonadotropins, letrozole, and ovarian drilling [10][11][12][13][14][15].…”

Section: Weight Reduction and Ovulation Inductionmentioning

confidence: 99%

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Ovulation Induction in Women with Polycystic Ovary Syndrome: What is the Optimal Option?

Oriji¹,

Nyengidiki²

2018

Debatable Topics in PCOS Patients

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Infertility is a distressing medical and psychosocial problem afflicting about a quarter of all couples wanting to reproduce their offspring. Majority of the anovulatory problem in the female, as a cause of infertility, is due to polycystic ovary syndrome (PCOS). This condition is a complex interplay of factors, which affect women even beyond their fertility. It has been found to increase the risk of other adverse condit i o n ss u c ha st h em e t a b o l i cs y n d r o m e ,c a r diovascular diseases, type II diabetes mellitus, and endometrial cancer as well as infertility. Different groups have made diagnosis of PCOS with various diagnostic criteria. The Rotterdam criteria used in the diagnosis of PCOS mainly emphasize the reproductive malfunctions of this complex disease. The treatment of anovulatory infertility in PCOS is as enigmatic as the disease itself. Various methods have been deployed to treat the anovulation with variable success. Clomiphene citrate is a traditional first-line drug in treating anovulation in women with PCOS. Weight reduction, letrozole, metformin, folliclestimulating hormone (FSH) and ovarian drilling are some of the other ways in which anovulation has been treated in these women. What method is more likely to succeed in treating the infertility from anovulation in PCOS and in what circumstance are the subject matters of this discussion.

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“…That weight loss as little as 5-10% of body weight can regularize menses and improve response to ovulation induction and fertility medications [9,12].…”

Section: Weight Reduction and Ovulation Inductionmentioning

confidence: 99%

Section: Weight Reduction and Ovulation Inductionmentioning

confidence: 99%

Ovulation Induction in Women with Polycystic Ovary Syndrome: What is the Optimal Option?

Oriji¹,

Nyengidiki²

2018

Debatable Topics in PCOS Patients

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“…У женщин с син-дромом поликистозных яичников (СПКЯ) около 40% беременностей заканчиваются самопроизвольным выки-дышем и не менее часто встречается ановуляторное бес-плодие. Нарушение репродукции при СПКЯ обусловлено взаимодействием множества факторов: гиперандрогени-ей, ожирением, гиперинсулинемией, инсулинорезистент-ностью, повышением уровня лютеинизирующего гормона и недостаточностью рецепторов в эндометрии [43][44][45][46]. Основа прегравидарной подготовки при СПКЯ -восста-новление двухфазного МЦ.…”

Section: наследственные тромбофилииunclassified

Pregravid preparation for women with a history of miscarriage

Пустотина¹,

Ахмедова²

2016

Med. sov.

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“…We excluded patients who refused to take part in the study, those who were diabetic and those who were on insulin sensitizing drugs. Cases of PCOS was diagnosed using Rot-Open Journal of Obstetrics and Gynecology terdam's criteria which stipulates the presence of a minimum of two of the following; oligoamenorrhoea, chronic anovulation, clinical signs of hyperandrogeneamia (hirsutism, acné, alopecia) or laboratory evidence of hyperandrogeneamia (raised testosterone or androstenedione levels) and polycystic ovaries on ultrasonography [11].…”

Section: Methodsmentioning

confidence: 99%

Insulin Sensitivity and Gynaecological Features of Infertile Cameroonian Females with Polycystic Ovary Syndrome: A Cross-Sectional Study

Dohbit¹,

Sobngwi²,

Kemfang³

et al. 2017

OJOG

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Background: Polycystic ovary syndrome (PCOS), characterized by ovulatory dysfunction, polycystic ovary (PCO), hyperandrogenism and insulin resistance is the commonest endocrine disorder in women of reproductive age. It is an intriguing pathology that involves the perpetuation of a vicious circle with reproductive, endocrine and metabolic components. We aimed to assess the reproductive features and insulin sensitivity (IS) in infertile women with or without PCOS. Materials and Methods: We carried out a cross-sectional analytic study at the outpatient Obstetrics and Gynaecology Department of the Yaounde Gyneco-obstetric and Pediatrics Hospital, Cameroon from September 1 st 2012 to March 31 st 2013 giving total study duration of 07 months.Laboratory analyses were carried out at the National Obesity Centre (NOC) of the Yaounde Central Hospital, Cameroon. Results: Overall, 36 infertile females were enrolled, which included 15 diagnosed cases of PCOS according to Rotterdam consensus meeting of 2003 and 21 non PCOS subjects as control.PCOS women were younger than non PCOS women (28.8 ± 5.5 vs. 35.0 ± 4.2 years; p = 0.0004). The majority of the women in the PCOS group were spaniomenorrheic (11/15), and ultrasonographic findings were typical of PCOS. Hirsutism score was higher in the PCOS group with a median of 9 (7 -13).Insulin sensitivity was impaired in two-thirds of the study population, with 12 women found to be insulin resistant (6 PCOS, 6 non PCOS), 12 patients had Apart from blood glucose levels (p = 0.007), all other anthropometric and biological parameters were not significant. Spearman's correlation identified fasting plasma glucose and total cholesterol as factors associated with insulin sensitivity in females with PCOS. Impaired fasting glucose was observed in 13 patients with 08 from the PCOS group. Conclusion: We conclude that young age, spaniomenorrhea and hirsutism are common findings in PCOS. Furthermore, our findings suggest that PCOS may be more of systemic metabolic disease than solely a purely gynecologic disorder as described hitherto. Despite normal fasting plasma glucose levels, a good proportion of these women has impaired insulin sensitivity and it is associated with a metabolic syndrome.

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American Association Of Clinical Endocrinologists, American College Of Endocrinology, And Androgen Excess And Pcos Society Disease State Clinical Review: Guide To The Best Practices In The Evaluation And Treatment Of Polycystic Ovary Syndrome - Part 2

Cited by 323 publications

References 76 publications

Ovulation Induction in Women with Polycystic Ovary Syndrome: What is the Optimal Option?

Ovulation Induction in Women with Polycystic Ovary Syndrome: What is the Optimal Option?

Pregravid preparation for women with a history of miscarriage

Insulin Sensitivity and Gynaecological Features of Infertile Cameroonian Females with Polycystic Ovary Syndrome: A Cross-Sectional Study

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