“…Available treatments for IBS‐D include dietary modification, probiotics, serotonin (5‐hydroxytryptamine type 3 [5‐HT 3 ]) receptor antagonists (eg, alosetron, ondansetron), opioid receptor agonists and antagonists (eg, loperamide, eluxadoline [Viberzi ® , Allergan, Irvine, CA]), nonsystemic antibiotics (eg, rifaximin [Xifaxan ® , Salix Pharmaceuticals, Bridgewater, NJ]), bile acid sequestrants (eg, cholestyramine, colesevelam), antidepressants (eg, tricyclic antidepressants, selective serotonin reuptake inhibitors), complementary and alternative medicine (eg, herbal therapies, mind‐body interventions [eg, cognitive behavioural therapy, hypnotherapy], and mechanical interventions [eg, yoga, acupuncture]). As no validated treatment algorithm exists for patients with IBS and diarrhoea, many treatments are frequently used to manage symptoms . Ideally, the selection of a therapy should be based on a careful assessment of both efficacy and adverse events (AEs).…”