American Heart Association; American Stroke Association Stroke Council. Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: co-sponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group

Thrombolysis in Patients Aged over 80 Years Is Equally Effective and Safe

“…In fact stroke's incidence increases with age in both genders, with an incidence of 38% in adults over 75 years old. [2][3][4] However, despite stroke's high prevalence in the elderly, intravenous alteplase (intravenous recombinant tissue plasminogen activator [IV-rtPA]), the only approved treatment for pharmacological revascularization in acute ischemic stroke, is licensed only in Europe for use in patients younger than 80 years old. 5 This seems to be related with frequent under-representation or exclusion of patients over the age of 80 years from clinical trials leading to uncertainty about the risk-benefit profile in these patients.…”

Ultrasonographic Markers of Vascular Risk in Patients with Asymptomatic Carotid Stenosis

“…For this purpose, we conducted a prospective investigation on asymptomatic subjects who received indication for the best medical therapy for each vascular risk condition. 14 …”

Contrast-enhanced magnetic resonance angiography in carotid artery disease: does automated image registration improve image quality?

“…Carotid artery stenosis is a treatable risk factor for ischaemic stroke [1][2][3][4]. Current guidelines recommend endarterectomy or stent-protected percutaneous transluminal angioplasty as treatments for symptomatic severe carotid stenosis with 70-99% reduction in luminal diameter, as defined by the North American Symptomatic Carotid Endarterectomy Trial (NASCET) [1].…”

“…Symptomatic moderate degree carotid stenoses in the 50-69% range may equally require treatment [1]. In addition, in selected patients with asymptomatic 60-99% carotid stenosis, endarterectomy may also be considered as a primary preventative measure according to current guidelines [2]. Quantitative assessment of carotid stenosis is thus an essential prerequisite for therapeutic decision-making in individual cases [18].…”

“…Atherosclerotic extracranial carotid stenosis has a high prevalence in the elderly and is a treatable risk factor for ischaemic stroke, causing approximately 20% of cases [1][2][3][4]. Duplex ultrasonography is the primary imaging investigation in the assessment of carotid stenosis, whereas catheter-based digital subtraction angiography (DSA) represents the gold standard [5].…”