American Heart Association EPI|Lifestyle Scientific Sessions: 2020 Meeting Highlights

Razavi, Alexander C.; Gingras, Véronique; Michos, Erin D.; Návar, Ann Marie; Brown, Sherry‐Ann; Delker, Erin; Foti, Kathryn; Harrison, Stephanie L.; Lü, Yifei; Nierenberg, Jovia L.; Scott, Jewel; Tang, Olive; Thomas, Alvin G.; Turkson‐Ocran, Ruth‐Alma; Wallace, Amelia S.; Zhang, Mingyu; Lancaster, Kristie J.; Lutsey, Pamela L.; Selvin, Elizabeth

doi:10.1161/jaha.120.017252

Cited by 2 publications

(2 citation statements)

References 90 publications

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“…In March 2020, during the American Heart Association EPI | LIFESTYLE 2020 Scientific Sessions it was reported that elderly people could live healthier lives by increasing their physical activity [4]. It should also be noted that elderly people have lower level of immunity, and physical exercises may help to improve the stress tolerance and activate the immune system.…”

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confidence: 99%

Effect of physical activity level on the course of pneumonia caused by COVID-19

Samoylov

Udalov

Nazaryan

et al. 2020

MES

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Data from medical records of 144 COVID-19 patients who completed inpatient treatment, as well as subsequent questionnaires using a modified questionnaire, were analyzed. The relationship between the level of physical activity, performance, and quality of life (before and after treatment), age, frequency of exercise therapy at the hospital stage, the presence of stool disorders, and episodes of increased blood pressure after treatment with the course of the disease were evaluated. Patients were divided into a control and experimental group depending on the initial subjective level of performance. The moderate form prevailed (69,44%). The mild form is typical for younger patients, patients older than 50 years make up 62,49% of the total number of cases of severe course. Patients who had a severe form of the disease noted the quality of life and performance before the disease at a lower level, in contrast to those who had a medium and light form. Initially leading a more active lifestyle, patients with initially higher performance and quality of life who performed exercise therapy at the hospital stage (with mild and moderate forms) have a more favorable course of the disease (reducing the time of hospitalization, early recovery of performance, reducing the number of CT scans). The initial higher physical activity contributes to a more favorable course of the disease. The initial higher physical activity contributes to a more favorable course of the disease. It is necessary to raise public awareness of the benefits of regular physical activity and its connection with the course of the disease, especially among the elderly, as well as to introduce exercise therapy at all stages of treatment.

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confidence: 99%

Effect of physical activity level on the course of pneumonia caused by COVID-19

Samoylov

Udalov

Nazaryan

et al. 2020

MES

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“…This may include identifying and managing traditional CVD risk factors, optimizing ART to minimize potential negative effects on lipid metabolism, and addressing mental health concerns through counseling and other interventions. The American Heart Association's Life's Simple 7 (LS7) concept of ideal cardiovascular health is not well understood in youths living with HIV when compared to the Healthy People 2020-2030 goals [31][32][33][34]. A higher LS7 score indicates better cardiovascular health and is associated with a lower incidence of CVD [35][36][37][38].…”

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confidence: 99%

Cardiovascular Risk Assessment Among Adolescents and Youths Living With HIV: Evaluation of Electronic Health Record Findings and Implications

et al. 2023

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Background The HIV epidemic remains a major public health concern, particularly among youths living with HIV. While the availability of antiretroviral therapy has significantly improved the health outcomes of people living with HIV, there is growing evidence that youths living with HIV may be at increased risk of cardiovascular disease. However, the underlying mechanisms linking HIV and cardiovascular disease among youths living with HIV remain poorly understood. One potential explanation is that HIV-related biomarkers, including detectable viral load (VL) and low cluster of differentiation 4 (CD4) lymphocyte counts, may contribute to increased cardiovascular risk. Despite the potential importance of these biomarkers, the relationship between HIV-related biomarkers and cardiovascular risk among youths living with HIV has been understudied. Objective To address this gap, we examined whether detectable VL and low CD4 lymphocyte counts, both of which are indications of unsuppressed HIV, were associated with cardiovascular risk among youths living with HIV. Methods We analyzed electronic health record data from 7 adolescent HIV clinics in the United States (813 youths living with HIV). We used multivariable linear regression to examine the relationship between detectable VL and CD4 lymphocyte counts of ≤200 and cardiovascular risk scores, which were adapted from the gender-specific Framingham algorithm. Results In our study, nearly half of the participants (366/766, 47.8%) had detectable VL, indicating unsuppressed HIV, while 8.6% (51/593) of them had CD4 lymphocyte counts of ≤200, suggesting weakened immune function. We found that those with CD4 lymphocyte counts of ≤200 had significantly higher cardiovascular risk, as assessed by Cardiac Risk Score2, than those with CD4 lymphocyte counts of >200 (P=.002). After adjusting for demographic and clinical factors, we found that for every 1000-point increase in VL copies/mL, the probability of having cardiovascular risk (Cardiac Risk Score2) increased by 38%. When measuring the strength of this connection, we observed a minor effect of VL on increased cardiovascular risk (β=.134, SE 0.014; P=.006). We obtained similar results with Cardiac Risk Score1, but the effect of CD4 lymphocyte counts of ≤200 was no longer significant. Overall, our findings suggest that detectable VL is associated with increased cardiovascular risk among youths living with HIV, and that CD4 lymphocyte counts may play a role in this relationship as well. Conclusions Our study highlights a significant association between unsuppressed HIV, indicated by detectable VL, and increased cardiovascular risk in youths living with HIV. These findings emphasize the importance of implementing interventions that address both VL suppression and cardiovascular risk reduction in this population. By tailoring interventions to meet the unique needs of youths, we can promote overall well-being throughout the HIV care continuum and across the life span. Ultimately, these efforts have the potential to improve the health outcomes and quality of life of youths living with HIV. International Registered Report Identifier (IRRID) RR2-10.2196/11185

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American Heart Association EPI|Lifestyle Scientific Sessions: 2020 Meeting Highlights

Cited by 2 publications

References 90 publications

Effect of physical activity level on the course of pneumonia caused by COVID-19

Effect of physical activity level on the course of pneumonia caused by COVID-19

Cardiovascular Risk Assessment Among Adolescents and Youths Living With HIV: Evaluation of Electronic Health Record Findings and Implications

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