American Heart Association's life simple 7 and the risk of atrial fibrillation in the PREDIMED study cohort

Díaz‐Gutiérrez, Jesús; Martínez‐González, Miguel Ángel; Alonso, Álvaro; Toledo, Estefanía; Salas‐Salvadó, Jordi; Sorlí, José V.; Ros, Emilio; Fitó, Montse; Estruch, Ramón; Arós, Fernando; Fiol, Miquel; Lapetra, José; Gómez‐Gracia, Enrique; Serra‐Majem, Lluís; Pintó, Xavier; Portolés, Olga; Babió, Nancy; Castañer, Olga; Ruiz‐Canela, Miguel

doi:10.1016/j.numecd.2023.02.004

Cited by 5 publications

(2 citation statements)

References 18 publications

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“…The Life's Simple (LS7) metrics were initiated by the American Heart Association (AHA) and proposed to promote cardiovascular health (CVH), which includes 7 modi able cardiovascular risk factors: manage blood pressure (BP), control cholesterol, reduce blood glucose, be physically active, eat better, lose weight and stop smoking [17]. The impact of adherence to LS7 on physical health has been studied in various chronic diseases, and results have shown that higher LS7 scores are associated with better cognitive function, lower risk of atrial brillation and depression, and a favorable prognosis after stroke [18][19][20][21]. In the eld of OSA, the impact of adherence to LS7 on OSA risk in adults has not been investigated, and scarce is known about the mediating effects of in ammation on the association between LS7 and OSA.…”

Section: Introductionmentioning

confidence: 99%

Association between adherence to Life’s Simple 7 metrics and risk of obstructive sleep apnea among adults in the United States

Wu,

Yang,

Zhu

et al. 2023

Preprint

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Objectives We aimed to explore the impact of adherence to Life's Simple 7 (LS7) metrics on risk of obstructive sleep apnea (OSA), and the impact of inflammation on the association, in adults in the United States.Methods Data from 13,825 community-dwelling adults aged ≥ 20 years recruited in the National Health and Nutrition Examination Surveys (NHANES) 2005–2008, 2015–2018 was analyzed. The LS7 score was calculated based on the AHA definition of LS7 metrics. The diagnosis of OSA was based on self-reported symptoms of sleep disturbance using a standard questionnaire. The Multivariable Apnea Prediction (MAP) Index score was also calculated to assess the risk of OSA. Log-binominal regression and negative binomial regression were performed to estimate the associations between LS7 and OSA and MAP index, with odds ratios (ORs) and prevalence ratios (PRs) and their 95% confidence intervals (CIs) calculated. Mediation analysis was performed to estimate the mediating effects of inflammatory indicators on the associations.Results A total of 4473 participants (32.4%) had OSA, and the mean MAP index was 0.39. In fully adjusted log-binominal regression models, with total score < 6 as the reference, the ORs (95% CIs) for risk of OSA were 0.90 (0.73, 1.10), 0.76 (0.65, 0.89), 0.78 (0.64, 0.95), and 0.45 (0.38, 0.54) for total score = 6, total score = 7, total score = 8, and total score > 8, respectively (P for trend < 0.001). When LS7 score was analyzed as a continuous variable, each 1-point increase in LS7 score was associated with a 15% decrease in OSA risk (P < 0.001). In negative binominal regression models, the adjusted PRs (95% CIs) for the MAP index were 0.93 (0.90, 0.97), 0.87 (0.84, 0.91), 0.80 (0.77, 0.84), and 0.55 (0.53, 0.57) for total score = 6, total score = 7, total score = 8, and total score > 8, respectively (P for trend < 0.001). For each 1-point increase in LS7 score, the risk of OSA decreased by 13% (P < 0.001). Consistent results were observed in subgroup analysis. Mediation analysis indicated that inflammatory factors, including blood cell count, neutrophil count, and C-reactive protein, positively mediated the association of LS7 with OSA, with a mediation proportion of 0.022 (P = 0.04), 0.02 (P = 0.04), and 0.02 (P = 0.02), respectively.Conclusions In a nationally representative sample of US adults, adherence to LS7 metrics was independently associated with reduced OSA risk. Inflammation plays a mediating role in the association between LS7 and OSA.

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Section: Introductionmentioning

confidence: 99%

Association between adherence to Life’s Simple 7 metrics and risk of obstructive sleep apnea among adults in the United States

Wu,

Yang,

Zhu

et al. 2023

Preprint

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“…Cardiovascular health scores addressing modifiable risk factors have been associated to the incidence and progression of AF. (162,163) Risk factor management through lifestyle modification reduces AF burden and severity. (77,85,86,89) Therefore, search for comorbidities is relevant to provide an integrated to AF patients and software tools can help into the identification of comorbidities (Figure 2).…”

Section: Sex Differences In Afmentioning

confidence: 99%

Towards understanding atrial cardiomyopathy in atrial fibrillation

Artola Arita

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Atrial fibrillation (AF) is the most common arrhythmia and is a growing epidemic.(1-6) The prevalence of AF has increased 3-fold in the last 50 years and recent data shows a lifetime risk of 1 in 3 in people with European ancestry and 1 in 5 people with Afro-American ancestry. (2,5) Available data estimates that AF affects on average 9 million people in Europe and 5 million people in the United States older than 55 years and it is expected that these ciphers double or triple by the year 2050.(2,6) The incidence of AF is increasing due to aging of the population, improved diagnostic tools to detect AF, more awareness of its existence and better survival due to advanced therapies for associated comorbidities. (2,5,6) AF is a progressive disease that often starts with sporadic self-terminating episodes and may evolve to more frequent, longer and non-self-terminating AF.( 7) AF progression has been associated with worse prognosis, such as an increase in development of heart failure (HF) hospitalizations,(8,9) stroke,(10) mortality,(10) and impairment of quality of life.( 11) Patients with AF often present with symptoms such as palpitations, fatigue, dizziness, dyspnoea, chest pain and anxiety.(12) However, AF may also be asymptomatic.( 13) AF almost never comes alone and is associated with risk factors and comorbidities, including hypertension, obesity and heart failure(Figure 1).(14,15) Risk factors and comorbidities may start already the remodelling processes of the atria (and ventricles) long before the first AF episode is being detected (Figure 2).(3,9,18) Established traditional risk factors and comorbidities include ageing, coronary heart disease, heart failure, hypertension, diabetes, obesity, significant valvular diseases, thyroid disease, and excessive as well as deficient physical activity (Figure 1).(3,6,15) Progression of AF further contributes to deterioration of the remodelling processes (Figure 2).( 17) AF also affects ventricular remodelling. (17) The presence of these risk factors and comorbidities cause electrical and structural changes in the atria, nowadays named Atrial Cardiomyopathy (ACM), and sets the stage for AF initiation and its progression.

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Life’s Essential 8, Genetic Susceptibility, and Incident Cardiac Arrhythmias: A Population-Based Prospective Cohort Study

Guo,

Chen,

Wang

et al. 2024

Canadian Journal of Cardiology

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American Heart Association's life simple 7 and the risk of atrial fibrillation in the PREDIMED study cohort

Cited by 5 publications

References 18 publications

Association between adherence to Life’s Simple 7 metrics and risk of obstructive sleep apnea among adults in the United States

Association between adherence to Life’s Simple 7 metrics and risk of obstructive sleep apnea among adults in the United States

Towards understanding atrial cardiomyopathy in atrial fibrillation

Life’s Essential 8, Genetic Susceptibility, and Incident Cardiac Arrhythmias: A Population-Based Prospective Cohort Study

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