American Joint Committee on Cancer Classification Predicts Outcome of Patients with Lacrimal Gland Adenoid Cystic Carcinoma

Ahmad, S; Esmaeli, Bita; Williams, Michelle D.; Nguyen, John; Fay, Aaron; Woog, John J.; Selvadurai, Deepan; Rootman, Jack; Weis, Ezekiel; Selva, Dinesh; McNab, Alan A.; DeAngelis, Dan; Calle, Alberto; López, Adriana

doi:10.1016/j.ophtha.2008.12.049

Cited by 107 publications

(79 citation statements)

References 24 publications

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“…The present case series showed two cases with solid growth pattern and T4N0M0 with distant metastasis four years after the surgery. These findings corroborate with previous conclusions of others investigators that the histologic pattern and initial staging of disease is of prognostic significance (24)(25)(26) . Mucoepidermoid carcinoma is a rare form of malignant tumor of the lacrimal gland (5) .…”

Section: Discussionsupporting

confidence: 93%

“…Two patients presented a painful palpable mass with rapid growth, proptosis and inferomedial displacement of the globe, and two presented, in addition to the symptoms and signs above, reduced visual acuity, choroidal folds, restricted ocular motility and swelling. According to the lite- rature, the adenoid cystic carcinoma is characterized clinically by a painful palpable mass with rapid growth, proptosis and inferomedial displacement of the globe (24) . Two cases with solid growth pattern presented an aggressive behavior with reduced visual acuity, restricted ocular motility, choroidal folds and swelling.…”

Section: Discussionmentioning

confidence: 99%

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Ten-year follow-up of a case series of primary epithelial neoplasms of the lacrimal gland: clinical features, surgical treatment and histopathological findings

Santos

Damasceno

Pontes

et al. 2010

Arq. Bras. Oftalmol.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Ten-year follow-up of a case series of primary epithelial neoplasms of the lacrimal gland: clinical features, surgical treatment and histopathological findings

Santos

Damasceno

Pontes

et al. 2010

Arq. Bras. Oftalmol.

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“…The epithelial component is invested in a densely collagenized or hyalinized connective tissue stroma. Among the classic patterns of growth of lacrimal AdCC, the most frequent is the cribriform [21], followed by basaloid/solid and tubular/ductal patterns. Tumors with a basaloid-solid pattern are the most infiltrative and are associated with a 5-year survival rate of only 21 % [22].…”

Section: Discussionmentioning

confidence: 99%

Lacrimal Gland Adenoid Cystic Carcinoma with High-Grade Transformation to Myoepithelial Carcinoma: Report of a Case and Review of Literature

Argyris

Pambuccian

Cayci

et al. 2012

Head and Neck Pathol

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Adenoid cystic carcinoma (AdCC) is the most frequent malignant neoplasm of the lacrimal glands. Like its salivary gland counterpart, lacrimal AdCC can rarely undergo high-grade transformation (''dedifferentiation''). We herein report the clinical, radiographic and microscopic findings of a lacrimal gland AdCC with high grade transformation, occurring in a 39-year-old female patient. In contrast to salivary gland AdCC with high-grade transformation, which usually shows a high grade component with ''ductal'' differentiation, in the case presented, the ''dedifferentiated'' component showed morphologic and immunohistochemical features of myoepithelial differentiation.

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“…The difficulties in localized control and the high tendency for regional recurrences in ACC are attributed to perineural infiltration and bone invasion [4]. Distant metastasis is seen in up to 50% of patients with ACC, with the lungs, bone, and liver reported as the most commonly affected sites [1,5,6,7]. In this report, we describe an unusual presentation of ACC of the lacrimal gland with isolated distant single-organ metastasis.…”

Section: Introductionmentioning

confidence: 92%

Incidentally Discovered Adenoid Cystic Carcinoma of the Lacrimal Gland with Isolated Liver Metastases

Maamari¹,

Custer²,

Harocopos³

2017

Ocul Oncol Pathol

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Aim: To report a rare presentation of adenoid cystic carcinoma (ACC) of the lacrimal gland. Method: This is a case report presenting clinical, radiographic, and histopathologic findings. Results: A 72-year-old female with no reported ocular symptoms was found to have an incidental right orbital mass on imaging. Additional studies revealed multiple liver lesions, which were biopsied and found to be consistent with ACC. She was then referred to the ophthalmology service, where ocular examination demonstrated 2.5 mm of right proptosis with elevation and abduction deficits. Diplopia could be elicited in extreme upgaze and right lateral gaze. An excisional biopsy of the orbital mass was performed, with histopathology confirming the diagnosis of primary ACC of the lacrimal gland, thereby also supporting the initial suspicion that the hepatic ACC lesions represented metastases. Conclusion: The authors describe a rare presentation of ACC of the lacrimal gland, initially asymptomatic, with metastatic lesions restricted to the liver at the time of diagnosis. Three previous cases of ACC with isolated metastatic hepatic lesions at the time of diagnosis have been reported; all of these cases localized the primary tumor to the salivary glands.

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American Joint Committee on Cancer Classification Predicts Outcome of Patients with Lacrimal Gland Adenoid Cystic Carcinoma

Cited by 107 publications

References 24 publications

Ten-year follow-up of a case series of primary epithelial neoplasms of the lacrimal gland: clinical features, surgical treatment and histopathological findings

Ten-year follow-up of a case series of primary epithelial neoplasms of the lacrimal gland: clinical features, surgical treatment and histopathological findings

Lacrimal Gland Adenoid Cystic Carcinoma with High-Grade Transformation to Myoepithelial Carcinoma: Report of a Case and Review of Literature

Incidentally Discovered Adenoid Cystic Carcinoma of the Lacrimal Gland with Isolated Liver Metastases

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