American Medical Society for Sports Medicine Position Statement: Principles for the Responsible Use of Regenerative Medicine in Sports Medicine

Abstract

Many sports medicine physicians are currently considering introducing regenerative medicine into their practice. Regenerative medicine and the subclassification of orthobiologics are a complicated topic and have produced widely varying opinions. Although there is concern by government regulators, clinicians, scientists, patient advocacy organizations, and the media regarding the use of regenerative medicine products, there is also excitement about the potential benefits with growing evidence that certain regenerative medicine products are safe and potentially efficacious in treating musculoskeletal conditions. Sports medicine physicians would benefit from decision-making guidance about whether to introduce orthobiologics into their practice and how to do it responsibly. The purpose of this position statement is to provide sports medicine physicians with information regarding regenerative medicine terminology, a brief review of basic science and clinical studies within the subclassification of orthobiologics, regulatory considerations, and best practices for introducing regenerative medicine into clinical practice. This information will help sports medicine physicians make informed and responsible decisions about the role of regenerative medicine and orthobiologics in their practice.

The Top 100 Most Cited Articles on Platelet-Rich Plasma Use in Regenerative Medicine—A Bibliometric Analysis—From the ESSKA Orthobiologic Initiative

“…Despite the popularity and massive use of PRP in regenerative medicine, medical practices remain heterogeneous, limiting its adoption as a standard of care in therapeutic strategies [ 20 ]. Several recommendations [ 21 , 22 , 23 , 24 ] and classifications [ 12 , 13 , 14 , 15 , 21 , 25 , 26 ] have emerged, encouraging both standardization and characterization of the injected biological products.…”

Influencing Factors of Physical Activity in Patients with Lung Cancer Surgery and Its Correlation with Exercise Self-Efficacy and Perceived Social Support

“…Physical activity (PA) refers to any physical activity that results in energy expenditure due to skeletal muscle movement [2]. e American College of Sports Medicine (ACSM) and the American Cancer Society have recommended physical activity as an intervention to help cancer survivors cope with pain, improve quality of life, and potentially prolong survival [3]. Research evidence shows [4][5][6][7][8] that regular and appropriate physical activity has a good e ect on the primary prevention of cancer patients, prolonging survival time, and improving quality of life.…”

Patients seeking stem cell therapies—a prospective qualitative analysis from a Regenerative Medicine Consult Service

“…Furthermore, some orthobiologic options, like platelet rich plasma do not contain stem cells yet are captured within the “stem cell” treatment (SCT) market. The growth of orthobiologics has resulted in many orthopedic and sports medicine societies publishing statements and recommending the responsible use of cell-based interventions 10 – 13 . As a result, responsible practitioners have attempted to navigate the difficult task of appropriately translating orthobiologic therapies despite the absence of clear clinical evidence in some applications and the presence of confounding and misleading claims permeating the field.…”