A thermoelectric analysis of space nuclear power reactor is of great importance to the space reactors development. In this paper, the reactor core model of TOPAZ-II designed by Soviet Union, including neutronics model, thermal-hydraulic model, and electrical circuit model, is established based on reasonable assumptions. A system analysis code is developed to analyze the thermoelectric characteristics of the TOPAZ-II under the condition of steady-state operation, start-up procedure, power change mode, and reactor shutdown. The code has been benchmarked with experimental data, and the maximum relative error is 16.6%. Numerical results show that for the steady state, the simulated electrical power is 5.2 kW within the design value range. For transient state, the reactor thermoelectric characteristics are mainly affected by the electrode temperature: (a) For the start-up procedure, when the emitter temperature increases above 1700 K, electrical system begins to work and reach full power in 5 minutes. (b) For power change mode, the emitter temperature decreases by 5%, while the electrical power decreases by 67%; (c) For reactor shutdown, electrical power reduces to 0 kW as the emitter temperature decreases to 1400 K in 100 seconds. This study provides valuable theoretical supports for the design and analysis of the thermionic space nuclear power reactor. KEYWORDS steady and transient analysis, thermoelectric characteristics, thermionic space nuclear power reactor Nomenclature: A, cross section area (m 2 ); C, delayed neutron precursor concentration (m −3 ); c, specific heat (J kg −1 K −1 ); D, diameter (m); e, electron charge, 1.602 × 10 −19 C; H, heat transfer coefficient (W m −2 K −1 ); I, current (A); J, current density (A/cm 2 ); k, boltzman constant, 1/11 600; N, number; P, power (W); Q, heat source (W m -3 ); r, radius (m); T, temperature (K); t, time (s); l, length (m); p, pressure (Pa); V, volume (m 3 )/voltage (V); W, mass flow rate (kg s −1 ) characteristics analysis of thermionic space nuclear power reactor. Int J Energy Res. 2020;44:855 868 .