Amianthoid fibres in a chondrosarcoma

Ghadially, F. N.; Lalonde, J.-M. A.; Yong, N. K.

doi:10.1002/path.1711300302

Cited by 35 publications

(10 citation statements)

References 8 publications

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“…1-3 It is apparently restricted to inguinal nodes and characterized by hemorrhagic spindle cell proliferation with multiple scattered areas of amorphous eosinophilic material suggestive of amianthoid fibers as Work supported by a grant of MURST 60% 1990 Address correspondence to Francesco Tanda. described in other pathological condit ions. [4][5][6][7] This tumor is of particular interest for several reasons: (1 1 primary mesenchymal tumors are exceptional in lymph nodes; (2)…”

Section: Introductionmentioning

confidence: 99%

Primary Spindle Cell Tumor of Lymph Node with “Amianthoid” Fibers: A Histological, Immunohistochemical and Ultrastructural Study

Tanda

Massarelli

Cossu

et al. 1993

Ultrastructural Pathology

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A primary mesenchymal spindle cell tumor with amianthoid fibers was observed in an inguinal lymph node of a 70-year-old woman. With immunohistochemical stains the cells were positive for muscle actin and negative for desmin. Transmission electron microscopy (TEM) showed intracytoplasmic bundles of microfilaments with focal densities, profiles of rough endoplasmic reticulum, and basementlike material indicative of myofibroblastic and/or smooth-muscle cell differentiation. At scanning electron microscopy (SEM) the tumor was organized into slitlike spaces containing red blood cells. Amianthoid fibers showed a strong positivity for actin at their edge with a central negative core; by TEM they appeared to be formed of 200 nm thick crystallized collagen fibers surrounded by actin microfilaments arranged in a palisading fashion. The immunohistochemical and ultrastructural findings of the proliferating myoid cells suggest a possible derivation from smooth-muscle vascular cells. Collagen fiber aggregation and actin filament dismission might be secondary to anoxia due to vascular obliteration or disruption.

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Section: Introductionmentioning

confidence: 99%

Primary Spindle Cell Tumor of Lymph Node with “Amianthoid” Fibers: A Histological, Immunohistochemical and Ultrastructural Study

Tanda

Massarelli

Cossu

et al. 1993

Ultrastructural Pathology

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“…Furthermore, some authors who studied AFs ultrastructurally did not mention anything about rosettes or radially arranged crystalline structures typically seen at the light microscopic level. ' [8][9][10][11][12][13][14][15][16][17][18][19][20] On the basis of ultrastructural observations, amianthoid fibres (AFs) were defined by Ghadially" as giant collagen fibres with a width of 280-1000 nm.…”

Section: Discussionmentioning

confidence: 99%

Collagen composition and ultrastructure of the so‐called amianthoid fibres in palisaded myofibroblastoma. Ultrastructural and immunohistochemical study

Skélové

Chlumské²,

Leivo

1992

The Journal of Pathology

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A very prominent feature of the recently described intranodal palisaded myofibroblastoma is the occurrence of stellate crystalline extracellular deposits known as 'amianthoid fibres', and thought to represent abnormally thick collagen fibrils. We showed at the ultrastructural level that these deposits are composed of fibrils with the periodicity and width typical of normal native collagen. Using antibodies directed against various extracellular components, we have determined that these structures contain type I and III collagens. Our results indicate that the crystalloid deposits in intranodal palisaded myofibroblastoma called 'amianthoid fibres' do not contain giant collagen fibrils widely regarded as characteristic of the morphological concept 'amianthoid' in other locations.

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“…The loss of overproduction of collagen observed in late passages indicates the presence of several populations of cells in the investigated fibroblast cultures. From the ultrastructural standpoint, one of the most characteristic findings is the increased thickness of collagen fibrils in the fascia, with some of the giatit collagen fibrils resembling amianthoid (asbestoid) fibers (24,25), Native collagen fibrils have diameters from about 30 to 120 nm. Amianthoid collagen fibers are 6 to 10 times wider than normal collagen fibrils.…”

Section: -mentioning

confidence: 99%

Congenital Fascial Dystrophy — A Noninflammatory Disease of Fascia: The Stiff Skin Syndrome

Jabłońska¹,

Groniowski²,

Krieg

et al. 1984

Pediatric Dermatology

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Our patient's disease was similar to the persons with stiff skin syndrome described by Esterly and McKusick (1). Stony-hard indurations of the skin and deeper tissue were generalized but most pronounced in the buttocks, thighs, and legs, with limitation of joint mobility and particularly extensive contractures in the lower limbs. The disease was noticed when the patient was 18 months old, and was nonprogressive within a follow-up period of 12 years. There was no visceral involvement except functional impairment of the lungs, probably due to thickened thoracic fascia. Biochemical, histologic, and electron microscopic studies of the skin and muscle were not remarkable. In skin fibroblasts, collagen synthesis was increased and was accompanied by elevated activity of the prolylhydroxylase and lysylhydroxylase, whereas the transferases were not altered. The fascia was considerably thickened, but contained no inflammatory infiltrates. The significant electron microscopic finding was the presence of amianthoid-like collagen fibers in the fascia.

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Amianthoid fibres in a chondrosarcoma

Abstract: Amianthoid fibres up to about 1000 nm thick were found in the matrix of a chondrosarcoma. Our findings support the idea that this is a degenerative change and that these fibres are probably formed by coalescence of collagen fibrils.

Cited by 35 publications

References 8 publications

Primary Spindle Cell Tumor of Lymph Node with “Amianthoid” Fibers: A Histological, Immunohistochemical and Ultrastructural Study

Primary Spindle Cell Tumor of Lymph Node with “Amianthoid” Fibers: A Histological, Immunohistochemical and Ultrastructural Study

Collagen composition and ultrastructure of the so‐called amianthoid fibres in palisaded myofibroblastoma. Ultrastructural and immunohistochemical study

Congenital Fascial Dystrophy — A Noninflammatory Disease of Fascia: The Stiff Skin Syndrome

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