Amide pectin: A carrier material for colon‐targeted controlled drug release

Abstract

In order to deliver bioactive components to the colon, an oral colon-targeted bioadhesive microparticle delivery system based on pectin was developed. Unmodified pectin exhibited a poor hydrophobicity and weak tablet-crushing strength. Pectin was modified by an amide reaction, which results in a dramatic decrease in water solubility and viscosity, as well as favorable controlled release properties. Amide pectin (AP) were characterized by Fourier transform infrared spectroscopy (FTIR), Nuclear magnetic resonance ( 1 H-NMR), and Differential scanning calorimetry (DSC). Results of FTIR and 1 H-NMR revealed that amide groups were introduced into the pectin molecules; DSC analysis exhibited that the thermal stability of pectin was decreased. An in vitro release assay demonstrated that matrix tablets prepared by AP could deliver bioactive components to the colon when the pectin content and hydrophobicity were properly controlled. The relationship between the structure and in vitro release properties of amide pectin suggests that an optimal tablet structure and composition can be responsible for a suitable BSA release rate. The optimal tablets making conditions were using methylcellulose (MC) as tablet adhesive, amidation reaction time of 60 min, drug loading of 0.008 g and tableting pressure of 8 kg/mm. The results indicated that matrix tablets made by AP exhibited good colon-targeted drug release.

Development of bionanocomposites of pectin and nanoemulsions of carnauba wax and neem oil pectin/carnauba wax/neem oil composites

“…Table shows that the nanoemulsions incorporation did not promote an effect on the tensile strength regarding to the control film ( P ≥ .05). Li et al and Otoni et al reported a reduction in tensile strength with the lipid phase incorporation in pectin films. In general, oil phase additions lead to the heterogeneous films formation with discontinuity in the polymer matrix .…”

“…The characterization was performed according to Li et al with modifications. The samples were prepared on KBr discs (1 mg sample in 100 mg KBr) with hydrostatic pressure at a force of 5 cm 2 .…”

Novel Pectin/Chia-Mucilage Membranes: Human Serum Albumin Adsorption, Biocompatibility, and Physical-Chemical Properties

“…Pectin (PC) is chemically a linear polymer of D-galacturonic acid with α (1-4) linkages sequences [10] that may also contain different monosaccharides domains (around 17). PC has been proposed as a biomaterial for developing drug-controlled delivery systems [11], wound dressing [12], wall material for bioactive microencapsulation [13], and reinforcement for other materials [14].…”

Alkylated pectin hydrogels as potential protein drug carriers

“…For example, polyacrylamide‐grafted pectin was used for controlling the delivery of salicylic acid . Amide pectin with improved solubility was applied for delivering bovine serum albumin (BSA), which exhibited sustained release in simulated digestive fluids …”