Amide proton transfer (APT) imaging of breast cancers and its correlation with biological status

Kamitani, Takeshi; Sagiyama, Koji; Yamasaki, Yoshio; Hino, Takuya; Wada, Tatsuhiro; Kubo, Makoto; Akiyoshi, Sayuri; Yamamoto, Hidetaka; Yabuuchi, Hidetake; Ishigami, Kousei

doi:10.1016/j.clinimag.2023.02.002

Cited by 4 publications

(5 citation statements)

References 24 publications

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“…Our study employed 3D APTw to better cater to intratumoral heterogeneity. Kamitani et al [20] used 3D APT in breast cancer and found that the APT value of TNBC was higher than Luminal type cancers and HER2 cancers, consistent with this study's ndings. Patients with TNBC typically have a relatively poorer outcome than those with other breast cancer subtypes owing to inherently aggressive clinical behavior and a lack of recognized molecular targets for therapy [25,26].…”

Section: Discussionsupporting

confidence: 91%

“…As an independent prognostic factor, breast cancer with a higher histological rate is less differentiated and has a poorer prognosis than breast cancer with a lower histological grade [38]. Most studies have demonstrated the association between APT value and grades [34,39], our analysis thought there was correlation between APT value and grades, but some studies have shown that there is no correlation between them [20]. Several factors could explain this inconsistency, such as the histological type of breast cancer (tumor fever chymosin).…”

Section: Discussionmentioning

confidence: 78%

“…While previous studies [15,33] demonstrated that IVIM diagnostic e cacy across breast cancer subtypes. Also, some previous [20,34,39] studies showed that APTw may be related to ER, PR, and HER2 expression. Our study combines the two imaging methods to reveal more possibilities for predicting breast cancer subtypes.…”

Section: Discussionmentioning

confidence: 89%

“…Predicting Ki-67 expression based on imaging is signi cant in clinical practice. Some studies [19,20] have shown an association between APT and Ki-67 expression. This could be attributed to the presence of high concentrations of mobile proteins and peptides during active tumor cell proliferation, potentially leading to increased APT values.…”

Section: Discussionmentioning

confidence: 99%

“…Liu et al [19] said that the APTw value signi cantly correlated with the Ki-67 index but showed no signi cant difference in groups of ER, PR, HER-2, and among molecular subtypes. Kamitani et al [20] reported that triple-negative and high-Ki-67 breast cancers showed high APT values. These discrepant ndings leave the value of APT imaging in evaluating breast cancer ambiguous.…”

Section: Introductionmentioning

confidence: 99%

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Three-Dimensional Turbo-Spin-Echo Amide Proton Transfer-weighted and Intravoxel Incoherent Motion Imaging MRI assessing the Triple-Negative Breast Cancer

Zhang,

Shao,

et al. 2023

Preprint

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Background：Accurate diagnosis of TNBC is essential before initiating therapeutic intervention.Intravoxel incoherent motion imaging (IVIM) MRI an alternative to breast biopsy for sub-typing of the triple-negative breast cancer (TNBC).amide proton transfer-weighted (APTw) MRI provides a new method for the diagnosis of TNBC.To investigate the potential of APTw MRI in assessing TNBC and to assess whether APTw MRI can enhance the diagnostic value of IVIM in breast MRI. Methods This prospective study involved 115 patients with suspected breast tumors who underwent both breast APTw and IVIM MRI. The APTw, diffusion coefficient (D), pseudo diffusion coefficient (D*), and perfusion fraction (f) values along with histological subtype, grade, and prognostic factors (Ki-67, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER-2), lymph node metastasis, and maximum lesion diameter) were compared. APT values were further analyzed in relation to biological subtypes, Ki-67 labeling index, and nuclear grades (NGs). Results A total of 67 participants (mean age, 64 years, ranges 29-71) were included in the evaluation. The TNBC (3.52 ± 0.38%) exhibited significantly higher APT values compared to the luminal A-type cancers (2.16 ± 1.12%) (P = 0.04). The luminal B cancers showed significantly lower f and Dmax values than the TN-type cancers (P=0.007,0.010). The HER2 cancers showed significantly lower APT values than TN-type ones (P=0.010).The APT value were notably higher in high-Ki-67 (2.80±1.39%) than in low-Ki-67 cancers (2.20±1.88%) (P = 0.045). There are significant difference in APT value was observed between NG1, NG2 and NG3 cancers (P=0.049). And APT value was also significant difference in stages T1 cancers (P=0.027). The combined diagnostic efficiency between TNBC from Luminal A was 0.955. Conclusion The combination of APTw and IVIM MRI holds promise for distinguishing TNBC by discerning molecular subtypes of breast cancers.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Three-Dimensional Turbo-Spin-Echo Amide Proton Transfer-weighted and Intravoxel Incoherent Motion Imaging MRI assessing the Triple-Negative Breast Cancer

Zhang,

Shao,

et al. 2023

Preprint

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The value of amide proton transfer imaging in predicting parametrial invasion and lymph-vascular space invasion of cervical cancer

Yang,

Hassan,

Omar

et al. 2025

Magnetic Resonance Imaging

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Evaluation of Amide Proton Transfer Imaging Combined With Serum Squamous Cell Carcinoma Antigen for Grading Cervical cancer

Zhang,

Xu,

et al. 2024

J Comput Assist Tomogr

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Objective The aim of the study is to investigate the efficacy of amide proton transfer-weighted (APT) imaging combined with serum squamous cell carcinoma antigen (SCC-Ag) in grading cervical cancer. Methods Sixty-three patients with surgically confirmed cervical SCC were enrolled and categorized into 3 groups: highly differentiated (G1), moderately differentiated (G2), and poorly differentiated (G3). The diagnostic efficacies of APT imaging and serum SCC-Ag, alone or in combination, for grading cervical SCC were compared. Results The APT values measured by the 2 observers were in excellent agreement (intraclass correlation coefficient >0.75). Mean (± standard deviation) APT values for the high, moderate, and poor differentiation groups were 2.542 ± 0.215% (95% confidence interval [CI]: 2.423–2.677), 2.784 ± 0.175% (95% CI: 2.701–2.856), and 3.120 ± 0.221% (95% CI: 2.950–3.250), respectively. APT values for groups G2 and G3 were significantly higher than those for G1 (P < 0.05). APT values for identifying cervical SCC in groups G1 and G2, G2 and G3, and G1 and G3, had areas under the receiver operating characteristic curve, sensitivities, and specificities of 0.815 (95% confidence interval [CI]: 0.674–0.914), 82.1%, and 72.2%, 0.882 (95% CI: 0.751–0.959), 70.6%, and 92.7%, and 0.961 (95% CI: 0.835–0.998), 94.1%, and 94.4%, respectively. APT values were significantly and positively correlated with the histological grade of cervical SCC (Spearman's correlation [r s] = 0.731, P < 0.01). Serum SCC-Ag levels for the high, moderate, and poor differentiation groups were 1.60 (0.88–4.63) ng/mL, 4.10 (1.85–6.98) ng/mL, and 26.10 (9.65–70.00) ng/mL, respectively. The differences were statistically significant only between groups G1 and G3 and G2 and G3 (P < 0.05), whereas the differences between groups G1 and G2 were not statistically significant (P > 0.05). Spearman's analysis revealed a positive correlation between SCC-Ag levels and the histological grade of cervical SCC (r s = 0.573, P < 0.01). The diagnostic efficacy of APT imaging for the histological grading of cervical SCC was better than that of serum SCC-Ag, and the discriminatory efficacy of the combination of the 2 parameters was better than that of either alone. Conclusions The diagnostic efficacy of APT imaging was better than that of serum SCC-Ag, and the combined diagnostic utility of APT and SCC-Ag was better than that of the individual parameters.

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Amide proton transfer (APT) imaging of breast cancers and its correlation with biological status

Cited by 4 publications

References 24 publications

Three-Dimensional Turbo-Spin-Echo Amide Proton Transfer-weighted and Intravoxel Incoherent Motion Imaging MRI assessing the Triple-Negative Breast Cancer

Three-Dimensional Turbo-Spin-Echo Amide Proton Transfer-weighted and Intravoxel Incoherent Motion Imaging MRI assessing the Triple-Negative Breast Cancer

The value of amide proton transfer imaging in predicting parametrial invasion and lymph-vascular space invasion of cervical cancer

Evaluation of Amide Proton Transfer Imaging Combined With Serum Squamous Cell Carcinoma Antigen for Grading Cervical cancer

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