Amidines. 3. Thioureas possessing antihypertensive activity

Loev, Bernard; Bender, Paul E.; Bowman, Helene; Helt, A.; McLean, R. A. N.; Jen, Timothy

doi:10.1021/jm00280a007

Cited by 37 publications

(17 citation statements)

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“…It also represent a new class of human immuno deficiency virus type (HIV-1), non-nucleoside reverse transcriptase (NNRT) inhibitors [9], found as antagonist of transient receptor potential channel antagonist [10] and high density lipoprotein (HDL) elevating agents [11,12]. The combination the urea derivatives with thiourea lead to inhibitors of DNA topoisomerase [13], antihypertensive activity [14]. Furthermore, the pronounced antimicrobial activity of urea as well as thiourea derivatives [15,16] encouraged us to study the effect of the synthesized compounds against a variety of microorganisms.…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis and evaluation of some 1,3,5-triazinyl urea and thiourea derivatives as antimicrobial agents

Chikhalia

Patel

2009

Journal of Enzyme Inhibition and Medicinal Chemistry

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Section: Introductionmentioning

confidence: 99%

Design, synthesis and evaluation of some 1,3,5-triazinyl urea and thiourea derivatives as antimicrobial agents

Chikhalia

Patel

2009

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…82, 83, 84, 85 and 86 show anti-hypertensive activity but greatest activity was observed for 85. [23] i) Thioureas as rodenticide Thioureas are best rodenticides. 87 (Alphanaphthyl thiourea) and 88 (phenyl thiourea) are most commonly used rodenticide.…”

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Thiourea Derivatives in Drug Design and Medicinal Chemistry: A Short Review

Shakeel¹

2016

JDDMC

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Abstract:Thioureas have great medicinal applications as well as non-medicinal activities in industry, analytical chemistry and metallurgy. This review is a glimpse of methods of synthesis and applications of thioureas in the field of medicine and agriculture. Thioureas have a number of medicinal applications and a number of thioureas are in clinical use. Medicinal applications of thioureas are increasing with the passage of time. In the field of agriculture, thioureas are used as insect growth regulator, anti-fungal agents and herbicides.

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“…Synthetic approaches to thioureas have been long investigated. 14 Well-known routes to substituted thioureas (Scheme 1) involve reactions of (i) anilines with sodium 15 or ammonium thiocyanate 16 in the presence of strong acids (TFA or concentrated HCl); (ii) aroyl isothiocyanates with amines followed by basic hydrolysis; 17 (iii) silicon tetraisothiocyanate with primary and secondary amines; 18 (iv) unsubstituted thioureas with primary alkyl amines at 170-180°C; 19 (v) isothiocyanates with ammonia or amines; 20 (vi) primary amines with carbon disulfide in the presence of mercury acetate and aqueous ammonia; 21 and (vii) disubstituted cyanamides with hydrogen chloride and LiAlHSH 22 or hydrogen sulfide in the presence of ammonia. 23 Mono and N,N-disubstituted thioureas were also prepared on solid support from Fmoc-isothiocyanate with subsequent deprotection.…”

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confidence: 99%

Synthesis of Mono- and N,N-Disubstituted Thioureas and N-Acylthioureas

Katritzky¹,

Kirichenko²,

Rogovoy³

et al. 2004

Synthesis

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1-Benzotriazole-1-carbothioamide (2), prepared from 1-cyanobenzotriazole (1) and hydrogen sulfide, reacts with amines to give thioureas 3a-e. Reactions of (benzotriazol-1-yl)carboximidamides 4a-d,f-j and acyl-5a-f,i-k or arylaminocarbonyl-5g,h (benzotriazol-1-yl)carboximidamides with hydrogen sulfide give the corresponding thioureas 3a-d,f-j, and N-acylthioureas 6a-f,i-k or N-carbamoylthioureas 6g,h, respectively.Thiourea moieties are important chemical building blocks that have numerous chemical and pharmaceutical applications. For example, recent reports describe thiourea derivatives as efficient guanylating agents both in solution 1 and on solid support. 2 Thermal decomposition of N-arylthioureas gives aryl isothiocyanates. 3 Oxidation of arylthioureas with lead tetraacetate 4 or iodic acid 5 affords arylcyanamides. Thioureas condense with a-halocarbonyl compounds to afford 2-amino-1,3-thiazoles. 6 Benzothiazoles can be prepared from arylthioureas in the presence of bromine. 7 Solid-phase Biginelli pyrimidine synthesis 8 and synthesis of imidazolone derivatives 9 using resin-bound thioureas have been reported. The uses of thioureas to make 1,3-thiazines, 10 1,3-diazines, 11 1,3-quinazolines 12 and 1,2,4-triazines 13 were also described recently.Synthetic approaches to thioureas have been long investigated. 14 Well-known routes to substituted thioureas (Scheme 1) involve reactions of (i) anilines with sodium 15 or ammonium thiocyanate 16 in the presence of strong acids (TFA or concentrated HCl); (ii) aroyl isothiocyanates with amines followed by basic hydrolysis; 17 (iii) silicon tetraisothiocyanate with primary and secondary amines; 18 (iv) unsubstituted thioureas with primary alkyl amines at 170-180°C; 19 (v) isothiocyanates with ammonia or amines; 20 (vi) primary amines with carbon disulfide in the presence of mercury acetate and aqueous ammonia; 21 and (vii) disubstituted cyanamides with hydrogen chloride and LiAlHSH 22 or hydrogen sulfide in the presence of ammonia. 23 Mono and N,N-disubstituted thioureas were also prepared on solid support from Fmoc-isothiocyanate with subsequent deprotection. 9 Scheme 1Acylthioureas are valuable starting materials for numerous transformations: acylthioureas were used for the preparation of four-, 24 five-, 25 six-25c,26 and seven-27 membered heterocyclic ring systems. N,N-Dialkyl-N¢-acyl(aroyl)thioureas are efficient ligands for the separation and refinement of platinum group metals (Pd, Rh, Ru, Ir, and Os). 28 Acylthiourea derivatives have been patented as antidiabetic, 29 antiarthritic, 30 antineoplastic, 31 and anticoagulant 32 agents and for treatment of cognitive problems 33 and prostate disorder. 34 Herbicidal, 35 fungicidal, 35 bactericidal, 35 insecticidal 36 and plant growth regulator activities have also been reported.Common routes to acylthioureas are presented in Scheme 2. Acylthioureas can be prepared by (i) reaction of aminothiocarbonylimidoyl chlorides with potassium thiocyanate followed by hydrolysis; 37 (ii) acylation of N,N-disubstituted thioureas; 38 (...

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Amidines. 3. Thioureas possessing antihypertensive activity

Cited by 37 publications

References 0 publications

Design, synthesis and evaluation of some 1,3,5-triazinyl urea and thiourea derivatives as antimicrobial agents

Design, synthesis and evaluation of some 1,3,5-triazinyl urea and thiourea derivatives as antimicrobial agents

Thiourea Derivatives in Drug Design and Medicinal Chemistry: A Short Review

Synthesis of Mono- and N,N-Disubstituted Thioureas and N-Acylthioureas

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