Amiloidosis cutánea localizada secundaria a poroqueratosis. Estudio histopatológico retrospectivo de 30 pacientes

Ramírez-Santos, A.; Suárez-Amor, Óscar; Pérez-Pérez, L.; Loureiro, Marcelo de Paula; Peteiro, C.; Toribio, Jaime

doi:10.1016/s0001-7310(08)74760-4

Cited by 9 publications

(1 citation statement)

References 24 publications

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“…The hair follicle, for example, is both target for and source of immunomodulatory stress mediators, similar to the hypothalamus–pituitary–adrenal axis (66,68,74). It is also well known that certain proteins are altered by inflammation, thus leading to the formation of amyloid deposits (75–79) in brain, skin and other organs (38,80). In skin, this type of amyloid is most often referred to as AA‐amyloid, because serum amyloid A (SAA) acts as the precursor protein (11).…”

Section: Brain–skin Axismentioning

confidence: 99%

Amyloid in skin and brain: What′s the link?

Schreml

Kaiser

Landthaler

et al. 2010

Experimental Dermatology

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For too long, amyloids have been under general suspicion to merely cause diseases. In recent years, we have learned that these interesting proteins may also fulfill important biological tasks. Moreover, recent publications show emerging evidence for a so-called brain-skin axis. This viewpoint paper aims to address the question what is known about the link between brain and skin based on the literature available for two diseases caused by amyloid formation: Alzheimer¢s disease (AD) and cutaneous amyloidoses. In addition, we acquaint the reader with a different perspective on the role of amyloid in skin and brain.

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Section: Brain–skin Axismentioning

confidence: 99%

Amyloid in skin and brain: What′s the link?

Schreml

Kaiser

Landthaler

et al. 2010

Experimental Dermatology

View full text Add to dashboard Cite

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Cutaneous Amyloidoses

Schreml

2016

Rook's Textbook of Dermatology, Ninth Edition

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Amyloids are common protein aggregates in nature. Some amyloids fulfil important biological tasks while others are known to cause diseases. Despite the fact that the ultrastructure of amyloid is highly conserved, the mechanism of amyloidogenesis remains a challenging research topic. In humans, amyloidoses can develop primarily in the skin, or systemic amyloidoses can lead to secondary cutaneous involvement. An accurate diagnostic procedure is crucial for planning therapy in this heterogeneous group of diseases. This chapter gives an overview of the different kinds of cutaneous amyloidoses as well as on diagnostic and therapeutic approaches. Furthermore, the contrast between functional and disease‐causing amyloid is discussed.

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Cutaneous Amyloidoses

Schreml

2024

Rook's Textbook of Dermatology

View full text Add to dashboard Cite

Amyloids are common protein aggregates in nature. Some amyloids fulfill important biological tasks while others are known to cause diseases. Despite the fact that the ultrastructure of amyloid is highly conserved, the mechanism of amyloidogenesis remains a challenging research topic. In humans, amyloidoses can develop primarily in the skin, or systemic amyloidoses can lead to secondary cutaneous involvement. An accurate diagnostic procedure is crucial for planning therapy in this heterogeneous group of diseases. This chapter gives an overview on the different kinds of cutaneous amyloidoses as well as on diagnostic and therapeutic approaches. Furthermore, the contrast between functional and disease‐causing amyloid is discussed.

show abstract

Amiloidosis cutánea localizada secundaria a poroqueratosis. Estudio histopatológico retrospectivo de 30 pacientes

Cited by 9 publications

References 24 publications

Amyloid in skin and brain: What′s the link?

Amyloid in skin and brain: What′s the link?

Cutaneous Amyloidoses

Cutaneous Amyloidoses

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