Aminaphtone in the control of gingival bleeding&amp;nbsp;in&amp;nbsp;children

godoy, Jose Maria Jose maria pereira de; Paizan, Mara Lucia Macedo

doi:10.2147/dddt.s65610

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…With regard to the treatment of stasis dermatitis, there are some reports on therapeutic options, yet with no emphasis on the physiopathological hypothesis of capillary fragility. The use of aminaphtone has recently been described as a therapeutic option in cases of ochre dermatitis and small hemorrhages [6]. In the present study, hyperpigmentation was controlled with the use of aminaphtone for three to four years, followed by a recurrence, which suggests that yet treatment is not curative and only achieves temporary control.…”

Section: Discussionmentioning

confidence: 44%

Control of ochre dermatitis with aminaphtone in an adolescent

Godoy¹,

Godoy²,

Godoy³

et al. 2023

Our Dermatol Online

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The aim of this manuscript is to report the case of a 22-year-old adolescent who presented with brownish patches on the skin of her lower legs persistent since the age of eleven years. She was treated by a dermatologist since the age of twelve years with a clinical diagnosis of ochre dermatitis confirmed by a biopsy. The patient was treated for two years without a success and was sent to a vascular surgeon at fourteen years of age. The diagnosis was confirmed, and the venous duplex scan discarded the possibility of a macrocirculation abnormality. The patient was treated with aminaphtone with the normalization of the skin for two years, after which the patches returned and were controlled again with the same medication. As ochre dermatitis may be associated with capillary fragility, the use of aminaphtone is a therapeutic option. Key words: Ochre Dermatitis; Hyperpigmentation; Capillary Fragility; Aminaphtone; Adolescent

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Section: Discussionmentioning

confidence: 44%

Control of ochre dermatitis with aminaphtone in an adolescent

Godoy¹,

Godoy²,

Godoy³

et al. 2023

Our Dermatol Online

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“…Moreover, Aminaphtone has been employed as adjuvant therapy in minor bleeding [5,33] and in purpuric disorders, such as Schamberg's disease [34].…”

Section: Downregulation Of Vascular Endothelial Growth Factor and Ede...mentioning

confidence: 99%

A Systematic Review of Aminaphtone from Pathophysiology to Clinical Applications: Focus on New Rheumatological Acquisitions

et al. 2023

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Aminaphtone is a chemical drug that has been used for more than thirty years to treat a variety of vascular disorders, with good clinical results and a satisfying safety profile. In the last two decades, multiple clinical studies have reported the efficacy of the drug in different clinical scenarios of altered microvascular reactivity, describing the downregulation of adhesion molecules (i.e., VCAM, ICAM, Selectins), vasoconstrictor peptides (i.e., Endothelin-1), and pro-inflammatory cytokine expression (i.e., IL-6, IL-10, VEGF, TGF-beta) by Aminaphtone. In this review, we summarize the current knowledge concerning Aminaphtone, with particular attention to rheumatological conditions in which microvascular disfunction plays a pivotal role, such as Raynaud’s phenomenon and systemic sclerosis. These latter conditions may represent a promising field of application for Aminaphtone, due to the growing pre-clinical, clinical, and instrumental reports of efficacy. However, randomized, double-blind, placebo-controlled clinical trials are lacking and are desirable.

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Aminaphtone in the control of gingival bleeding in children

Cited by 2 publications

References 7 publications

Control of ochre dermatitis with aminaphtone in an adolescent

Control of ochre dermatitis with aminaphtone in an adolescent

A Systematic Review of Aminaphtone from Pathophysiology to Clinical Applications: Focus on New Rheumatological Acquisitions

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