2021
DOI: 10.3390/molecules26237179
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Amination of 5-Spiro-Substituted 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones

Abstract: The 3-hydroxy-1,5-dihydro-2H-pyrrol-2-one motif is a valuable scaffold in drug discovery. The replacement of the 3-oxy fragment in 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones-based compounds with a 3-amino one (3-amino analogs of 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones, 3-amino-1,5-dihydro-2H-pyrrol-2-ones) can play a crucial role in their biological effect. Thus, approaches to 3-amino-1,5-dihydro-2H-pyrrol-2-ones are of significant interest. We developed an approach to 5-spiro-substituted 3-amino-1,5-dihydro-2H-pyr… Show more

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Cited by 3 publications
(2 citation statements)
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“…Noteworthy, we had to derivatize product 3aa to detect it by HPLC–UV during the optimization studies. For these purposes, compound 3aa was converted to compound 4 by an earlier procedure developed by us ( Scheme 7 ) [ 51 ]. Without this derivatization procedure, we could not accurately detect compound 3aa by HPLC–UV, since the chromatographic signals of untreated compound 3aa were broad and blurry.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Noteworthy, we had to derivatize product 3aa to detect it by HPLC–UV during the optimization studies. For these purposes, compound 3aa was converted to compound 4 by an earlier procedure developed by us ( Scheme 7 ) [ 51 ]. Without this derivatization procedure, we could not accurately detect compound 3aa by HPLC–UV, since the chromatographic signals of untreated compound 3aa were broad and blurry.…”
Section: Resultsmentioning
confidence: 99%
“…As in the cases of the above studied reactions ( Scheme 7 , Scheme 12 ), we had to derivatize the product 12aa ( Scheme 17 ) by an earlier procedure developed by us [ 51 ] in order to investigate the reaction optimization by HPLC-UV.…”
Section: Resultsmentioning
confidence: 99%