Amine containing phenylboronic acid gel for glucose-responsive insulin release under physiological pH

Effect of Coordination on the Glucose‐Responsiveness of PEG‐b‐(PAA‐co‐PAAPBA) Micelles

“…Another approach to reduce the pK a of PBA derivatives is to place amine in close proximity to PBA groups. As reported by Kataoka, [9] they have used an amine content in a phenylboronic acid based hydrogel, poly[m-methacrylamidophenyl boronic-co-N,N-dimethylaminopropylacryl-amide-co-acrylamide-co-N,N-methylenebis(acrylamide)], which enhanced complexation between glucose and PBA groups and altered the glucose-responsiveness at physiological pH. Todd Hoare and Robert Pelton [10] have introduced N,N-dimethylamino ethylacrylate in a PBA based microgel and effectively lowered the pK a of PBA by direct coordination between the amine and PBA groups.…”

Glucose‐sensitive holographic sensors

“…Co-monomers which reduce the pK a of boronic acid by acting as electron donors could also be co-polymerized with 4-VPBA or other phenylboronic acid ligands and acrylamide. Shiino et al (1995) have shown that this can be achieved with tertiary amines co-polymerised with phenylboronic acid.…”

A Fluorescent Responsive Hybrid Nanogel for Closed-Loop Control of Glucose

“…1 While it has been possible to obtain glucose-responsive hydrogels within a considerable range, the lag time of bulk gels to reach swelling/collapsing equilibrium is thought to be the stumbling block to the realization of a gel-based closed-loop glycemic control system. [2][3][4] Theoretically, swelling/collapsing processes of gels are determined by the collective diffusion of the polymer networks in a fluid. The characteristic time period that describes the volume change of gels is approximately proportional to the square of the characteristic length of the gel.…”