Amine-functionalized Cu-MOF nanospheres towards label-free hepatitis B surface antigen electrochemical immunosensors

Abstract

Metal-organic framework (MOF) nanomaterials offer a wide range of promising applications due to their unique properties, including open micro- and mesopores and rich of functionalization. Herein, a facile synthesis via...

Au@Zr-based metal–organic framework composite as an immunosensing platform for determination of hepatitis B virus surface antigen

“…A comparison of this method with other methods developed for the detection of HBsAg is given in Table 1. These comparisons illustrate that the Au@UiO-66(NH 2 ) composite-based electrochemical sensor has several advantages, including a LOD and LDR for HBsAg when evaluated against most of the electrodes modified with different nanomaterials [37][38][39][40][41][42][43][44][45][46][47][48]. The previously reported sensors based on other nanomaterials showed good performance, but the better performance of the Au@UiO-66(NH 2 ) composite may be attributed to the large surface area of UiO-66(NH 2 ), high electrocatalytic activity of Au, and the fast electron transfer mediation from the immobilized HBsAg.…”

Electrochemical studies of biofunctionalized MoS2 matrix for highly stable immobilization of antibodies and detection of lung cancer protein biomarker

“…Furthermore, a linear variation of i pa and i pc with (Fig. 8(b)) shows that the process of reduction and oxidation of [Fe(CN) 6 ] 3−/4− at the immunoelectrode is diffusion-controlled, 33,34 which indicates that adsorbents when get conjugated on the electrode will inhibit the diffusion of [Fe(CN) 6 ] 3−/4− . The linearly fitted plots as shown in Fig.…”

“…Furthermore, a linear variation of i pa and i pc with ffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffi ScanRate p (Fig. 8(b)) shows that the process of reduction and oxidation of [Fe(CN) 6 ] 3À/4À at the immunoelectrode is diffusion-controlled, 33,34 which indicates that adsorbents when get conjugated on the electrode will inhibit…”

Developing an Electrochemical Biosensor for the Detection of Hemagglutinin Protein of Influenza A Virus Subtype H1N1 in Artificial Saliva

“…The electrode was dried under a stream of nitrogen and identified as NH 2 -AuNP-CSPE. The amine functionality in the electrode could be used later to form an amide bond [12] and immobilize the mouse monoclonal antibodies against the HA H1N1 protein.…”