Amine-functionalized porous silica production via ex- and in-situ method using silicate precursors as a selective adsorbent for CO2 capture applications

Abdul Ajiz, Hendrix; Widiyastuti, W.; Setyawan, Heru; Nurtono, Tantular

doi:10.1016/j.heliyon.2024.e26691

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e26691

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Amine-functionalized porous silica production via ex- and in-situ method using silicate precursors as a selective adsorbent for CO2 capture applications

Hendrix Abdul Ajiz,

W. Widiyastuti,

Heru Setyawan

et al.

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2024

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Cited by 3 publications

References 29 publications

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Behavior of tunable ZnO quantum dots (QDs) stabilized by surfactant-free silica nanofluids in their visible luminescence spectra

Nurtono,

Abdul Ajiz,

Widiyastuti

et al. 2024

Advanced Powder Technology

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Behavior of tunable ZnO quantum dots (QDs) stabilized by surfactant-free silica nanofluids in their visible luminescence spectra

Nurtono,

Abdul Ajiz,

Widiyastuti

et al. 2024

Advanced Powder Technology

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Perovskites as Multiphoton Fluorescence Contrast Agents for In Vivo Imaging

Nath,

Liversage,

Mortensen

et al. 2024

ACS Appl. Mater. Interfaces

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Multiphoton fluorescence microscopy is a powerful tool for imaging and exploring biological tissue at subcellular spatial resolution while minimizing photobleaching and autofluorescence. For optimal performance in multiphoton microscopy, materials exhibiting a large multiphoton absorption cross section (σ n ) and fluorescence quantum yield are desired. Notably, perovskite nanocrystals (CsPbX 3 , PNCs) exhibit exceptionally large two-, three-, up to five photon absorption cross section (σ 2 ∼ 10 6 GM, σ 3 ∼ 10 −73 cm 6 s 2 photon −2 , σ 5 ∼ 10 −136 cm 10 s 4 photon −4 ), along with near unity fluorescence quantum yield, making them desirable for deep tissue applications. Here, we employed PNCs as contrast agents to image mesenchymal stromal cells in a living mouse. The PNCs were stabilized by encapsulating them in a SiO 2 matrix (∼60−70 nm in diameter), offering versatility for subsequent surface modification to target specific biological entities for both diagnostic and therapeutic applications. Multiphoton imaging of PNCs offers substantial benefits for dynamic tracking of cells in deep tissue, such as in understanding immune cell migration and other biological processes in both healthy and diseased tissues.

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Dual-Functionalized Mesoporous Silica Nanoparticles for Celecoxib Delivery: Amine Grafting and Imidazolyl PEI Gatekeepers for Enhanced Loading and Controlled Release with Reduced Toxicity

Mudhakir,

Sadaqa,

Permana

et al. 2024

Molecules

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The development of targeted drug delivery systems has been a pivotal area in nanomedicine, addressing challenges like low drug loading capacity, uncontrolled release, and systemic toxicity. This study aims to develop and evaluate dual-functionalized mesoporous silica nanoparticles (MSN) for targeted delivery of celecoxib, enhancing drug loading, achieving controlled release, and reducing systemic toxicity through amine grafting and imidazolyl polyethyleneimine (PEI) gatekeepers. MSN were synthesized using the sol–gel method and functionalized with (3-aminopropyl) triethoxysilane (APTES) to create amine-grafted MSN (MSN-NH2). Celecoxib was loaded into MSN-NH2, followed by conjugation of imidazole-functionalized PEI (IP) gatekeepers synthesized via carbodiimide coupling. Characterization was conducted using Fourier-transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (1H-NMR). Drug loading capacity, entrapment efficiency, and in vitro drug release at pH 5.5 and 7.4 were evaluated. Cytotoxicity was assessed using the MTT assay on RAW 264.7 macrophages. The synthesized IP was confirmed by FTIR and 1H-NMR. Amine-grafted MSN demonstrated a celecoxib loading capacity of 12.91 ± 2.02%, 2.1 times higher than non-functionalized MSN. In vitro release studies showed pH-responsive behavior with significantly higher celecoxib release from MSN-NH2-celecoxib-IP at pH 5.5 compared to pH 7.4, achieving a 33% increase in release rate within 2 h. Cytotoxicity tests indicated significantly higher cell viability for IP-treated cells compared to PEI-treated cells, confirming reduced toxicity. The dual-functionalization of MSN with amine grafting and imidazolyl PEI gatekeepers enhances celecoxib loading and provides controlled pH-responsive drug release while reducing systemic toxicity. These findings highlight the potential of this advanced drug delivery system for targeted anti-inflammatory and anticancer therapies.

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Amine-functionalized porous silica production via ex- and in-situ method using silicate precursors as a selective adsorbent for CO2 capture applications

Cited by 3 publications

References 29 publications

Behavior of tunable ZnO quantum dots (QDs) stabilized by surfactant-free silica nanofluids in their visible luminescence spectra

Behavior of tunable ZnO quantum dots (QDs) stabilized by surfactant-free silica nanofluids in their visible luminescence spectra

Perovskites as Multiphoton Fluorescence Contrast Agents for In Vivo Imaging

Dual-Functionalized Mesoporous Silica Nanoparticles for Celecoxib Delivery: Amine Grafting and Imidazolyl PEI Gatekeepers for Enhanced Loading and Controlled Release with Reduced Toxicity

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