Amine‐Mediated Domino Reaction of Thioisatins: Synthesis of Benzothiophene‐fused N‐Heterocycles under Catalyst‐Free Conditions

Abstract

A novel three‐component domino reaction between thioisatins, α‐bromoketones, and amines was developed. The reaction with aliphatic amines produced a series of benzothiophene fused pyrrolidones in good yields. Moreover, employment of diamines gave benzothiophene fused polycyclic compounds. In addition, gram‐scale experiments and synthetic transformations on the resulting products were performed.