Amine neuromediators, their precursors, and oxidation products in the culture of Escherichia coli K-12

Shishov, V. A.; Kirovskaya, T. A.; Кудрин, В. С.; Oleskin, Alexander V.

doi:10.1134/s0003683809050068

Cited by 129 publications

(112 citation statements)

References 2 publications

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“…Vagal signals from the gut could induce an anti‐inflammatory reaction in a nicotinic acetylcholine receptor α7 subunit–dependent manner [40]. Furthermore, many metabolites have been reported to be produced by gut bacteria that play an important role in the central nervous function not only such as gamma‐amino butyric acid [41], serotonin [42], norepinephrine [43], acetylcholine [44], but also indole‐3‐propionic acid [45], controlling inflammation through interaction with G‐protein‐coupled receptor 43 expressed on neutrophils and eosinophils [46].…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effect of a new photobiomodulation technique against Aβ_25–35 peptide–induced toxicity in mice: Novel hypothesis for therapeutic approach of Alzheimer's disease suggested

Blivet

Meunier

Roman

et al. 2018

A&D Transl Res & Clin Interv

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IntroductionPhotobiomodulation was assessed as a novel treatment of Alzheimer’s disease (AD) by the use of a new device RGn500 combining photonic and magnetic emissions in a mouse model of AD.MethodsFollowing the injection of amyloid β 25-35 peptide in male Swiss mice, RGn500 was applied once a day for 7 days either on the top of the head or the center of abdomen or both.ResultsRGn500 daily application for 10 min produced a neuroprotective effect on the neurotoxic effects of amyloid β 25-35 peptide injection when this type of photobiomodulation was applied both on the head and on the abdomen. Protection was demonstrated by memory restoration and on the normalization of key markers of AD (amyloid β 1-42, pTau), oxidative stress (lipid peroxidation), apoptosis (Bax/Bcl2) and neuroinflammation.DiscussionRGn500 displays therapeutic efficacy similar to other pharmacological approaches evaluated in this model of AD.

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Section: Discussionmentioning

confidence: 99%

Neuroprotective effect of a new photobiomodulation technique against Aβ_25–35 peptide–induced toxicity in mice: Novel hypothesis for therapeutic approach of Alzheimer's disease suggested

Blivet

Meunier

Roman

et al. 2018

A&D Transl Res & Clin Interv

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“…Moreover, BAs have significant physiological functions, as they are precursors for the synthesis of hormones, alkaloids, nucleic acids and proteins (Spano et al, 2010). Histamine is an immune mediator and a neurotransmitter, while putrescine, spermidine and spermine are important for cell growth and differentiation, stabilization of DNA and RNA transcription, protein synthesis, apoptosis and regulation of the immune response (Igarashi & Kashiwagi, 2010;Oleskin et al, 2014;Özoǧul, 2004;Shishov, Kirovskaya, Kudrin, & Oleskin, 2009;Tsavkelova, Botvinko, Kudrin, & Oleskin, 2000;Yunes et al, 2016). Therefore, the ideal concentrations of these compounds and their potential deleterious effects on felines are still uncertain.…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary yeast cell wall on faecal bacteria and fermentation products in adult cats

Santos

Aquino

Glória

et al. 2018

Animal Physiology Nutrition

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This study evaluated the effects of increasing concentrations of spray-dried yeast cell wall (YCW) in diets for healthy adult cats on apparent nutrient digestibility and on bacterial composition and fermentation products in the stool. Fourteen cats with an average weight of 4.40 ± 1.05 kg and an average age of 6.2 ± 0.54 years were used and assigned to treatments in an unbalanced randomized block design (by experimental period) with two blocks and three or four cats per diet in each block. Treatments included: control (0% YCW), 0.2% YCW, 0.4% YCW and 0.6% YCW, totalling seven animals per experimental diet. We found that YCW did not affect body weight, nutrient and food intake, faecal production, faecal score, faecal pH or urine output (p > .05). Regarding faecal bacteria, we observed a linear reduction in Clostridium perfringens, a quadratic reduction in Escherichia coli, and linear increases in Bifidobacterium spp. and Lactobacillus spp. (p < .05) with the inclusion of YCW. Regarding the faecal short-chain fatty acid profile, butyrate, valerate, total biogenic amines, putrescine, cadaverine and histamine increased linearly (p < .05) with the inclusion of YCW. It was concluded that in healthy adult cats, consumption of YCW modulates the faecal bacterial populations, with an increased presence of beneficial bacteria and a reduction in some potentially pathogenic bacteria. It was concluded that YCW modulated the levels of fermentation products. There was an increase in fermentation products coming from carbohydrate metabolism, an important effect that can potentially benefit the intestinal health of cats. The consumption of YCW also increased the fermentation of nitrogen compounds, which have not yet been defined as deleterious or beneficial. The fermentability of carbohydrates and nitrogen compounds may be associated. Therefore, YCW may cause rapid fermentation of both classes of compounds by enhancing the fermentability of one class.

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“…By using GC‐MS, LC‐MS, and DESI‐IMS, the level of norepinephrine and dopamine could be monitored. Some bacteria species could release norepinephrine and dopamine out of cell, which might participate in crosstalk between microbe and host . Asano et al detected substantially upregulated levels of free dopamine and noradrenaline in gut lumen of mice, which demonstrated that gut microbiota contributed to the generation of the biologically active and free form of catecholamines in gut lumen.…”

Section: Co‐metabolism Of Gut Microbiota and The Host In Neurologicalmentioning

confidence: 99%

Mass spectrometry‐based metabolomics: Targeting the crosstalk between gut microbiota and brain in neurodegenerative disorders

Luan

Xian

Cai

2017

Mass Spectrometry Reviews

145

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Metabolomics seeks to take a "snapshot" in a time of the levels, activities, regulation and interactions of all small molecule metabolites in response to a biological system with genetic or environmental changes. The emerging development in mass spectrometry technologies has shown promise in the discovery and quantitation of neuroactive small molecule metabolites associated with gut microbiota and brain. Significant progress has been made recently in the characterization of intermediate role of small molecule metabolites linked to neural development and neurodegenerative disorder, showing its potential in understanding the crosstalk between gut microbiota and the host brain. More evidence reveals that small molecule metabolites may play a critical role in mediating microbial effects on neurotransmission and disease development. Mass spectrometry-based metabolomics is uniquely suitable for obtaining the metabolic signals in bidirectional communication between gut microbiota and brain. In this review, we summarized major mass spectrometry technologies including liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry, and imaging mass spectrometry for metabolomics studies of neurodegenerative disorders. We also reviewed the recent advances in the identification of new metabolites by mass spectrometry and metabolic pathways involved in the connection of intestinal microbiota and brain. These metabolic pathways allowed the microbiota to impact the regular function of the brain, which can in turn affect the composition of microbiota via the neurotransmitter substances. The dysfunctional interaction of this crosstalk connects neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease and Huntington's disease. The mass spectrometry-based metabolomics analysis provides information for targeting dysfunctional pathways of small molecule metabolites in the development of the neurodegenerative diseases, which may be valuable for the investigation of underlying mechanism of therapeutic strategies.

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Amine neuromediators, their precursors, and oxidation products in the culture of Escherichia coli K-12

Cited by 129 publications

References 2 publications

Neuroprotective effect of a new photobiomodulation technique against Aβ_25–35 peptide–induced toxicity in mice: Novel hypothesis for therapeutic approach of Alzheimer's disease suggested

Neuroprotective effect of a new photobiomodulation technique against Aβ_25–35 peptide–induced toxicity in mice: Novel hypothesis for therapeutic approach of Alzheimer's disease suggested

Effects of dietary yeast cell wall on faecal bacteria and fermentation products in adult cats

Mass spectrometry‐based metabolomics: Targeting the crosstalk between gut microbiota and brain in neurodegenerative disorders

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Amine neuromediators, their precursors, and oxidation products in the culture of Escherichia coli K-12

Cited by 129 publications

References 2 publications

Neuroprotective effect of a new photobiomodulation technique against Aβ25–35 peptide–induced toxicity in mice: Novel hypothesis for therapeutic approach of Alzheimer's disease suggested

Neuroprotective effect of a new photobiomodulation technique against Aβ25–35 peptide–induced toxicity in mice: Novel hypothesis for therapeutic approach of Alzheimer's disease suggested

Effects of dietary yeast cell wall on faecal bacteria and fermentation products in adult cats

Mass spectrometry‐based metabolomics: Targeting the crosstalk between gut microbiota and brain in neurodegenerative disorders

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Product

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Neuroprotective effect of a new photobiomodulation technique against Aβ_25–35 peptide–induced toxicity in mice: Novel hypothesis for therapeutic approach of Alzheimer's disease suggested

Neuroprotective effect of a new photobiomodulation technique against Aβ_25–35 peptide–induced toxicity in mice: Novel hypothesis for therapeutic approach of Alzheimer's disease suggested