Amine oxidases in apoptosis and cancer

Toninello, Antonio; Pietrangeli, Paola; Marchi, Umberto De; Salvi, Mauro; Mondovı̀, Bruno

doi:10.1016/j.bbcan.2005.09.001

Cited by 56 publications

(58 citation statements)

References 139 publications

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“…It is also likely that the higher abundance of acrolein conjugates in the urine represent higher levels of acrolein production. Unlike HNE, which is generated mainly by lipid peroxidation, acrolein is also produced in cells from sources such as the oxidation of amino acids by myeloperoxidase (38) or the metabolism of biogenic amines (37), and therefore, its production may be higher than HNE. In addition to endogenous sources, acrolein is also present in several foods, tobacco smoke, and automobile exhaust (39).…”

Section: Discussionmentioning

confidence: 99%

“…These aldehydes are generated upon oxidation of unsaturated lipids. In addition, acrolein is generated during the metabolism of biogenic amines (37) or by the oxidation of amino acids by myeloperoxidase (38). Acrolein is also present in a variety of food products and in cotton, wood, and tobacco smoke as well as automobile exhaust (39).…”

Section: Carnosine-aldehyde Metabolites In Human Urine-previousmentioning

confidence: 99%

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Role of Aldose Reductase in the Metabolism and Detoxification of Carnosine-Acrolein Conjugates

Baba

Hoetker

Merchant

et al. 2013

Journal of Biological Chemistry

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Background: Lipid peroxidation generates unsaturated aldehydes that form conjugates with histidyl dipeptides. Results: Carnosine-aldehyde conjugates form covalent adducts with proteins and are reduced by aldose reductase. Conclusion: Detoxification of carnosine-aldehyde by aldose reductase prevents protein carnosinylation. Significance: Aldose reductase prevents tissue injury due to aldehyde-carnosine conjugates.

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Section: Discussionmentioning

confidence: 99%

Section: Carnosine-aldehyde Metabolites In Human Urine-previousmentioning

confidence: 99%

Role of Aldose Reductase in the Metabolism and Detoxification of Carnosine-Acrolein Conjugates

Baba

Hoetker

Merchant

et al. 2013

Journal of Biological Chemistry

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“…Overall, to date 10 genes gave clear concordant results between transcript and protein. These include MAOA, TMPRSS2, and DAD1 (see Reportable Outcomes Lucas et al (2008) [16][17][18][19][20][21][22]. We completed 'outcomes' studies of the TMPRSS2 antibody on the Gelman TMA and found no correlation with relapse that was independent of Gleason Grade (see Reportable Outcomes Lucas et al (2008)).…”

Section: Objective 1b Ihc Analysis/confirmation Of Protein Expressiomentioning

confidence: 99%

“…We have completed the analysis of serum samples representing low grade and high-grade cancer as well as benign and metastasis for the two antigens passing the ELISA q/c metrics. We identified a stage-association for serum osteopontin, but a grade-association was not identified for either protein ( Figure 3 [14][15][16][17][18][19][20][21][22][23][24]. We have completed the analysis of serum samples representing low grade and high-grade cancer as well as benign and metastasis for the two additional antigens passing the ELISA q/c metrics.…”

Section: Objective 1b Ihc Analysis/confirmation Of Protein Expressiomentioning

confidence: 99%

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Exploiting a Molecular Gleason Grade for Prostate Cancer Therapy

Nelson¹

2010

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. (From -To) 15 Feb 2007 -14 Feb 2010 REPORT DATE (DD-MM-YYYY) 01-03-2010 REPORT TYPE Final DATES COVERED TITLE AND SUBTITLE Exploiting a Molecular Gleason Grade for Prostate Cancer Therapy PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Fred Hutchinson Cancer Research Center PERFORMING ORGANIZATION REPORT NUMBERSeattle, WA 98109-1024 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland SPONSOR/MONITOR'S REPORT 21702-5012 NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for public release; distribution unlimited SUPPLEMENTARY NOTES ABSTRACTThe Purpose of this proposal is to exploit a molecular correlate of the Gleason grading system for prostate carcinoma in order to: a) develop improved outcome predictors; and b) identify therapeutic strategies. During this project period we have evaluated 37 prostate cancer antigens by Western blot and tissue-based assays and identified 15 with detectable levels in the plasma. Serum levels of osteopontin discriminated men with highly advanced cancer. Tissue levels of MAOA associated with relapse after prostatectomy. We determined that major challenge for the evaluation of all candidate outcome-associated proteins centers on the lack of antibodies with suitable performance characteristics of specificity and sensitivity. This limitation impacts both tissue (IHC) and ELISA-based studies of protein localization and quantitation. Newer technologies for protein quantitation such as SISCAPA and MRM may address these limitations, but they require additional optimization. References……………………………………………………………………………. 9 Appendices…………………………………………………………………………… 9Nelson-PC060595-Progress Report 03/2010-Year 3-FINAL 4 INTRODUCTIONThis proposal was designed to exploit a molecular correlate of the Gleason grading system for prostate carcinoma in order to: a) develop improved outcome predictors; and b) identify therapeutic strategies targeted toward features unique to aggressive cancers. We hypothesized that the specific molecular features that underlie prostate cancer grades define the...

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