Amines Related to Epinephrine. II. Some More Amines of the “Eprocaine” Type

Abstract

water and was dried in vacuo at 100°over phosphorus pentoxide; 1.1 g. (48.2% of the theoretical yield) of crystals was obtained which melted at 200-205°. Several recrystallizations from hot water to a constant microbiological activity gave silky needles which melted at 206-208°.

Oxazoline Ring-Opening

“…Other examples are given in the experimental section as are structure proofs based on alkaline hydrolysis of the esters. The previously reported value is 132-133° (11). By the action of thionyl chloride this was converted to a crystalline compound, probably the sulfinyl chloride, which rearranged in dioxane to give the oxazoline salt.…”