Amino Acid-Functionalized MoS₂ Quantum Dots for Selective Antibacterial Activity

Abstract

The surface functionalization of nanomaterial is relevant in terms of its selectivity toward a bacterial strain. Recently, semiconducting nanomaterials have been gaining much attention in the development of nanomaterial-based alternative antibiotics. Among the various semiconducting materials, molybdenum disulfide (MoS2) has been gaining considerable interest due to its unique electronic, physical, and chemical properties. The semiconducting nature, high colloidal stability, and biocompatibility make it a promising candidate in the field of biomedical research. The development of antibacterial material based on MoS2 quantum dots is still in its infancy. Here, we have explored the effect of hydrophobic amino acid-modified MoS2 quantum dots toward their antibacterial activity. Functionalization enhances the antibacterial activity and selectivity depending on the amino acid residue. MoS2 quantum dots with a leucine-functionalized ligand show selective antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), whereas MoS2 quantum dots with a phenylalanine-functionalized ligand show almost equal antibacterial efficacy against both MRSA and Pseudomonas aeruginosa (PA).

Superparamagnetic Nickel Nanocluster-Embedded MoS2 Nanosheets for Gram-Selective Bacterial Adhesion and Antibacterial Activity

“…The bacterial adhesion on the surface of the nanomaterial helps to disrupt the cell wall integrity and leads to cell death. − Barman et al showed that the self-assembled polyurethane capsule exhibits selective antibacterial activity against the Gram-negative bacteria Escherichia Coli . Latter from our group, it has been reported that amino acid-functionalized MoS 2 quantum dots showed selective antibacterial activity . Furthermore, nanomaterials having magnetic properties, such as iron/nickel/cobalt-based nanoparticles, have been widely used as nanocarriers for drug delivery. , In addition, various surface-functionalized magnetic nanoparticles have been used to separate bacteria magnetically from the bacterial solution. , Until now, to the best of our knowledge, using superparamagnetic nanocomposite materials that exhibit high Gram-selective bacterial adhesion and antibacterial activity has not been reported so far.…”

“…44 Latter from our group, it has been reported that amino acidfunctionalized MoS 2 quantum dots showed selective antibacterial activity. 45 Furthermore, nanomaterials having magnetic properties, such as iron/nickel/cobalt-based nanoparticles, have been widely used as nanocarriers for drug delivery. 46,47 In addition, various surface-functionalized magnetic nanoparticles have been used to separate bacteria magnetically from the bacterial solution.…”

Defect-Engineered Functionalized MoS2 Quantum Dots with Enhanced Antibacterial Activity

“…They have used ion irradiation method to introduce sulfur vacancies in the QDs, which leads to the generation of a strong ROS-independent oxidative stress . Previously, from our group, it has been reported that the amino acid-functionalized MoS 2 QDs exhibit selective antibacterial activity . MoS 2 QDs are also used in drug delivery applications due to their good biocompatibility and rapid cellular uptake .…”

Gram-selective antibacterial activity of mixed-charge 2D-MoS2

“…We also showed that inhibiting the enzyme responsible for antibacterial activity can be used to develop combinatorial antibacterial agents. 61–64…”