Amino Acid Homeostasis in the Small Intestine. II. Studies in Man

Gent, A. E.; Creamer, B.

doi:10.1159/000197260

Cited by 3 publications

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“…The present report indicates that the succus entericus contains free amino acids in high concentrations as well as peptides, which are readily hydrolyzed by the enzyme system present in that secretion. Amino acid analyses of succus entericus were reported for the dog (26), the rat (7), and man (8), but it is unclear whether adequate precautions were taken to prevent extensive digestion of peptides present in the juice before amino acid content was determined.…”

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confidence: 99%

Possible Role of Succus Entericus in Amino Acid Homeostasis in the Dog

Nasset¹

1977

Digestion

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Succus entericus from jejunal Thiry-Vella fistulae in fasting conscious dogs was analyzed for amino acids before and after incubation for 15 and 30 min at 38 °C in vitro. Total amino acid concentration of succus entericus as collected was about twice that of blood plasma. After incubation, it was increased 76% above control at 15 min and 137% at 30 min. Because succus entericus does not exhibit proteinase activity, and no enzyme or substrate was added before incubation, the increase in amino acid concentration was probably due to hydrolysis of peptides by peptidases normally present in the juice. Volume of secretion and output of amino acids were greatly increased by intravenous administration of glucagon, but the amino acid pattern was quite different from blood plasma. The concentrations of aspartic and glutamic acids were 10- and 5-fold greater than in plasma, and tryptophan was usually undetectable.

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confidence: 99%